Mark D. Does, Ph.D.

Position: Associate Professor

Department: Biomedical Engineering

Lab Url: N/A

Email: mark.does@vanderbilt.edu

Office Address: 1161 21st Avenue South
Office Address2: AA-1105 MCN
Nashville , TN 37232-2310
Phone :(615) 322-8352
Fax: (615) 322-0734

Lab Address: AAA-3125 Medical Center North/VUIIS


Mark D. Does's picture
  Mark D. Does, Ph.D.
Patient Care Specialty
MRI, Small Animal Imaging,Neuroscience,NMR,Physiology

Research Description
Current Research Projects:

-Characterization of Neural Tissue and Skeletal Muscle with MRI
using Relaxation, Magnetization Transfer, and Diffusion

-Compartmental Modelling of Water Proton Relaxation and Diffusion
with computational methods, chemical phantoms, and compartment-specific contrast agents

-Cortical Bone Imaging with Magnetic Resonance

-Development/Optimization of MRI pulse sequence
for rapid relaxometry
for diffusion measurement at very short diffusion times
for small animal cardiac imaging,
for MR microscopy

Publications
Dortch, RD, Horch, RA, Does, MD. Development, simulation, and validation of NMR relaxation-based exchange measurements. J Chem Phys, 131(16), 164502, 2009

Dortch, RD, Yankeelov, TE, Yue, Z, Quarles, CC, Gore, JC, Does, MD. Evidence of multiexponential T2 in rat glioblastoma. NMR Biomed, 22(6), 609-18, 2009

Dula, AN, Gochberg, DF, Does, MD. Optimal echo spacing for multi-echo imaging measurements of Bi-exponential T2 relaxation. J Magn Reson, 196(2), 149-56, 2009

Louie, EA, Gochberg, DF, Does, MD, Damon, BM. Transverse relaxation and magnetization transfer in skeletal muscle: effect of pH. Magn Reson Med, 61(3), 560-9, 2009

Viquez, OM, Lai, B, Ahn, JH, Does, MD, Valentine, HL, Valentine, WM. N,N-diethyldithiocarbamate promotes oxidative stress prior to myelin structural changes and increases myelin copper content. Toxicol Appl Pharmacol, 239(1), 71-9, 2009

Xu, J, Does, MD, Gore, JC. Quantitative characterization of tissue microstructure with temporal diffusion spectroscopy. J Magn Reson, 200(2), 189-97, 2009

Xu, J, Does, MD, Gore, JC. Sensitivity of MR diffusion measurements to variations in intracellular structure: Effects of nuclear size. Magn Reson Med, 61(4), 828-833, 2009

Colvin, DC, Yankeelov, TE, Does, MD, Yue, Z, Quarles, C, Gore, JC. New insights into tumor microstructure using temporal diffusion spectroscopy. Cancer Res, 68(14), 5941-7, 2008

Fan, RH, Does, MD. Compartmental relaxation and diffusion tensor imaging measurements in vivo in lambda-carrageenan-induced edema in rat skeletal muscle. NMR Biomed, 21(6), 566-73, 2008

Byrd, JB, Shreevatsa, A, Putlur, P, Foretia, D, McAlexander, L, Sinha, T, Does, MD, Brown, NJ. Dipeptidyl peptidase IV deficiency increases susceptibility to angiotensin-converting enzyme inhibitor-induced peritracheal edema. J Allergy Clin Immunol, 120(2), 403-8, 2007

Dortch, RD, Does, MD. Temporal DeltaB0 and relaxation in the rat heart. Magn Reson Med, 58(5), 939-46, 2007

Eagleson, KL, Schlueter McFadyen-Ketchum, LJ, Ahrens, ET, Mills, PH, Does, MD, Nickols, J, Levitt, P. Disruption of Foxg1 expression by knock-in of Cre recombinase: Effects on the development of the mouse telencephalon. Neuroscience, 148(2), 385-99, 2007

Horch, RA, Does, MD. Aqueous urea as a model system for bi-exponential relaxation. MAGMA, 20(1), 51-6, 2007

Qin, Q, Gore, JC, Does, MD, Avison, MJ, de Graaf, RA. 2D arbitrary shape-selective excitation summed spectroscopy (ASSESS). Magn Reson Med, 58(1), 19-26, 2007

Qin, Q, Gore, JC, de Graaf, RA, Does, MD. Quantitative T (2) measurement of a single voxel with arbitrary shape using pinwheel excitation and CPMG acquisition. MAGMA, 20(5-6), 233-40, 2007

Valentine, HL, Does, MD, Marshall, V, Tonkin, EG, Valentine, WM. Multicomponent T(2) analysis of dithiocarbamate-mediated peripheral nerve demyelination. Neurotoxicology, 28(3), 645-54, 2007

Xu, J, Does, MD, Gore, JC. Numerical study of water diffusion in biological tissues using an improved finite difference method. Phys Med Biol, 52(7), N111-26, 2007

Andrews, TJ, Osborne, MT, Does, MD. Diffusion of myelin water. Magn Reson Med, 56(2), 381-5, 2006

Parsons, EC, Does, MD, Gore, JC. Temporal diffusion spectroscopy: theory and implementation in restricted systems using oscillating gradients. Magn Reson Med, 55(1), 75-84, 2006

Does, MD. Relaxation-selective magnetization preparation based on T1 and T2. J Magn Reson, 172(2), 306-11, 2005

Travis, AR, Does, MD. Selective excitation of myelin water using inversion-recovery-based preparations. Magn Reson Med, 54(3), 743-7, 2005

Does, Mark D, Parsons, Edward C, Gore, John C. Oscillating gradient measurements of water diffusion in normal and globally ischemic rat brain. Magn Reson Med, 49(2), 206-15, 2003

Parsons, Edward C, Does, Mark D, Gore, John C. Modified oscillating gradient pulses for direct sampling of the diffusion spectrum suitable for imaging sequences. Magn Reson Imaging, 21(3-4), 279-85, 2003

Rybicki, Anne C, Fabry, Mary E, Does, Mark D, Kaul, Dhananjay K, Nagel, Ronald L. Differential gene expression in the kidney of sickle cell transgenic mice: upregulated genes. Blood Cells Mol Dis, 31(3), 370-80, 2003

Does, Mark D, Gore, John C. Compartmental study of T(1) and T(2) in rat brain and trigeminal nerve in vivo. Magn Reson Med, 47(2), 274-83, 2002

Dutka, Michael V, Scanley, B Ellen, Does, Mark D, Gore, John C. Changes in CBF-BOLD coupling detected by MRI during and after repeated transient hypercapnia in rat. Magn Reson Med, 48(2), 262-70, 2002

Fong, P M, Keil, D C, Does, M D, Gore, J C. Polymer gels for magnetic resonance imaging of radiation dose distributions at normal room atmosphere. Phys Med Biol, 46(12), 3105-13, 2001

Gore, J C, Anderson, A W, Does, M D, Gochberg, D F, Joers, J M, Kennan, R P, Parsons, E C, Schachter, M. The relationship of problems in biomedical MRI to the study of porous media. Magn Reson Imaging, 19(3-4), 295-300, 2001

Does, M D, Gore, J C. Complications of nonlinear echo time spacing for measurement of T (2). NMR Biomed, 13(1), 1-7, 2000

Does, M D, Gore, J C. Compartmental study of diffusion and relaxation measured in vivo in normal and ischemic rat brain and trigeminal nerve. Magn Reson Med, 43(6), 837-44, 2000

Does, M D, Gore, J C. Rapid acquisition transverse relaxometric imaging. J Magn Reson, 147(1), 116-20, 2000

Schachter, M, Does, M D, Anderson, A W, Gore, J C. Measurements of restricted diffusion using an oscillating gradient spin-echo sequence. J Magn Reson, 147(2), 232-7, 2000

Does, M D, Zhong, J, Gore, J C. In vivo measurement of ADC change due to intravascular susceptibility variation. Magn Reson Med, 41(2), 236-40, 1999

Does, M D, Beaulieu, C, Allen, P S, Snyder, R E. Multi-component T1 relaxation and magnetisation transfer in peripheral nerve. Magn Reson Imaging, 16(9), 1033-41, 1998

Does, M D, Snyder, R E. Multiecho imaging with suboptimal spoiler gradients. J Magn Reson, 131(1), 25-31, 1998

Beaulieu, C, Does, M D, Snyder, R E, Allen, P S. Changes in water diffusion due to Wallerian degeneration in peripheral nerve. Magn Reson Med, 36(4), 627-31, 1996

Does, M D, Snyder, R E. Multiexponential T2 relaxation in degenerating peripheral nerve. Magn Reson Med, 35(2), 207-13, 1996

Does, M D, Snyder, R E. T2 relaxation of peripheral nerve measured in vivo. Magn Reson Imaging, 13(4), 575-80, 1995


Postdoctoral Position Available
N/A

Postdoctoral Position Details
N/A

Updated Date
09/21/2009

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