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| Ronald M. Baldwin, Ph.D.
Position: Research Associate Professor
Department: Radiology and Radiological Sciences
Lab Url:
N/A
Email:
ronald.baldwin@vanderbilt.edu
Office Address:
Office Address2: MCN CCC-1118
1161 21st Avenue South
Nashville
, TN 37232-2675
Phone :(615) 936-2817
Fax: 615-322-3764
Lab Address: 1268D RRB
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| Patient Care Specialty |
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radiochemistry
organic chemistry
radiopharmaceutical development,Biochemistry,Molecular medicine |
| Research
Specialty |
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Radiopharmaceutical research for developing and understanding radiotracers for positron emission tomography (PET) imaging in vivo |
| Publications
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Baldwin, RM, Zoghbi, SS, Staley, JK, Brenner, E, Al-Tikriti, MS, Amici, L, Fujita, M, Innis, RB, Tamagnan, G. Chemical fate of the nicotinic acetylcholinergic radiotracer [123I]5-IA-85380
in baboon brain and plasma. Nucl Med Biol, 33(4), 549-54, 2006 de Paulis, T, Hemstapat, K, Chen, Y, Zhang, Y, Saleh, S, Alagille, D, Baldwin, RM, Tamagnan, GD, Conn, PJ. Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive
allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes. J Med Chem, 49(11), 3332-44, 2006 Alagille, D, Baldwin, RM, Roth, BL, Wroblewski, JT, Grajkowska, E, Tamagnan, GD. Synthesis and receptor assay of aromatic-ethynyl-aromatic derivatives with
potent mGluR5 antagonist activity. Bioorg Med Chem, 13(1), 197-209, 2005 Alagille, D, Baldwin, RM, Roth, BL, Wroblewski, JT, Grajkowska, E, Tamagnan, GD. Functionalization at position 3 of the phenyl ring of the potent mGluR5 noncompetitive
antagonists MPEP. Bioorg Med Chem Lett, 15(4), 945-9, 2005 Baldwin, RM. Imaging MAO-A levels by PET using the deuterium isotope effect. J Nucl Med, 46(9), 1411-3, 2005 Best, SE, Sarrel, PM, Malison, RT, Laruelle, M, Zoghbi, SS, Baldwin, RM, Seibyl, JP, Innis, RB, van Dyck, CH. Striatal dopamine transporter availability with [(123)I]beta-CIT SPECT is unrelated
to gender or menstrual cycle. Psychopharmacology (Berl), 183(2), 181-9, 2005 Brenner, E, Baldwin, RM, Tamagnan, G. Asymmetric synthesis of (+)-(S,S)-reboxetine via a new (S)-2-(hydroxymethyl)morpholine
preparation. Org Lett, 7(5), 937-9, 2005 Riccardi, P, Li, R, Ansari, MS, Zald, D, Park, S, Dawant, B, Anderson, S, Doop, M, Woodward, N, Schoenberg, E, Schmidt, D, Baldwin, R, Kessler, R. Amphetamine-Induced Displacement of [(18)F] Fallypride in Striatum and Extrastriatal
Regions in Humans. Neuropsychopharmacology, 31(5), 1016-1026, 2005 Staley, JK, Gottschalk, C, Petrakis, IL, Gueorguieva, R, O''Malley, S, Baldwin, R, Jatlow, P, Verhoeff, NP, Perry, E, Weinzimmer, D, Frohlich, E, Ruff, E, van Dyck, CH, Seibyl, JP, Innis, RB, Krystal, JH. Cortical gamma-aminobutyric acid type A-benzodiazepine receptors in recovery
from alcohol dependence: relationship to features of alcohol dependence and cigarette smoking. Arch Gen Psychiatry, 62(8), 877-88, 2005 Staley, JK, Sanacora, G, Tamagnan, G, Maciejewski, PK, Malison, RT, Berman, RM, Vythilingam, M, Kugaya, A, Baldwin, RM, Seibyl, JP, Charney, D, Innis, RB. Sex Differences in Diencephalon Serotonin Transporter Availability in Major
Depression. Biol Psychiatry, 59(1), 40-47, 2005 Staley, JK, van Dyck, CH, Weinzimmer, D, Brenner, E, Baldwin, RM, Tamagnan, GD, Riccardi, P, Mitsis, E, Seibyl, JP. 123I-5-IA-85380 SPECT measurement of nicotinic acetylcholine receptors in human
brain by the constant infusion paradigm: feasibility and reproducibility. J Nucl Med, 46(9), 1466-72, 2005 Tamagnan, G, Alagille, D, Fu, X, Kula, NS, Baldessarini, RJ, Innis, RB, Baldwin, RM. Synthesis and monoamine transporter affinity of new 2beta-carbomethoxy-3beta-[4-(substituted
thiophenyl)]phenyltropanes: discovery of a selective SERT antagonist with picomolar potency. Bioorg Med Chem Lett, 15(4), 1131-3, 2005 Tamagnan, G, Alagille, D, Fu, X, Kula, NS, Baldessarini, RJ, Innis, RB, Baldwin, RM. Synthesis and monoamine transporter affinity of new 2beta-carbomethoxy-3beta-[aryl
or heteroaryl]phenyltropanes. Bioorg Med Chem Lett, , , 2005 van Dyck, CH, Malison, RT, Jacobsen, LK, Seibyl, JP, Staley, JK, Laruelle, M, Baldwin, RM, Innis, RB, Gelernter, J. Increased dopamine transporter availability associated with the 9-repeat allele
of the SLC6A3 gene. J Nucl Med, 46(5), 745-51, 2005 Bois, Frederic, Baldwin, Ronald M, Kula, Nora S, Baldessarini, Ross J, Innis, Robert B, Tamagnan, Gilles. Synthesis and monoamine transporter affinity of 3''-analogs of 2-beta-carbomethoxy-3-beta-(4''-iodophenyl)tropane
(beta-CIT). Bioorg Med Chem Lett, 14(9), 2117-20, 2004 Chaly, Thomas, Baldwin, R M, Neumeyer, John L, Hellman, Matthew J, Dhawan, Vijay, Garg, Pradeep K, Tamagnan, Gilles, Staley, Julie K, Al-Tikriti, Mohammed S, Hou, Yankun, Zoghbi, Sami S, Gu, Xiao Hui, Zong, R, Eidelberg, David. Radiosynthesis of [18F] N-(3-Fluoropropyl)-2-beta-Carbomethoxy-3-beta-(4-Bromophenyl)
Nortropane and the regional brain uptake in non human primate using PET. Nucl Med Biol, 31(1), 125-31, 2004 Fujita, Masahiro, Southwick, Steven M, Denucci, Christopher C, Zoghbi, Sami S, Dillon, Martha S, Baldwin, Ronald M, Bozkurt, Ali, Kugaya, Akira, Verhoeff, N Paul L G, Seibyl, John P, Innis, Robert B. Central type benzodiazepine receptors in Gulf War veterans with posttraumatic
stress disorder. Biol Psychiatry, 56(2), 95-100, 2004 Kugaya, Akira, Sanacora, Gerard, Staley, Julie K, Malison, Robert T, Bozkurt, Ali, Khan, Shaukat, Anand, Amit, Van Dyck, Christopher H, Baldwin, Ronald M, Seibyl, John P, Charney, Dennis, Innis, Robert B. Brain serotonin transporter availability predicts treatment response to selective
serotonin reuptake inhibitors. Biol Psychiatry, 56(7), 497-502, 2004 Tokuno, Hajime A, Bradberry, Charles W, Everill, Brian, Agulian, Samuel K, Wilkes, Steven, Baldwin, Ronald M, Tamagnan, Gilles D, Kocsis, Jeffery D. Local anesthetic effects of cocaethylene and isopropylcocaine on rat peripheral
nerves. Brain Res, 996(2), 159-67, 2004 van Dyck, Christopher H, Malison, Robert T, Staley, Julie K, Jacobsen, Leslie K, Seibyl, John P, Laruelle, Marc, Baldwin, Ronald M, Innis, Robert B, Gelernter, Joel. Central serotonin transporter availability measured with [123I]beta-CIT SPECT
in relation to serotonin transporter genotype. Am J Psychiatry, 161(3), 525-31, 2004 Baldwin, Ronald M, Fu, Xing, Kula, Nora S, Baldessarini, Ross J, Amici, Louis, Innis, Robert B, Tamagnan, Gilles D. Synthesis and affinity of a possible byproduct of electrophilic radiolabeling
of [123I]IBZM. Bioorg Med Chem Lett, 13(22), 4015-7, 2003 Fujita, Masahiro, Al-Tikriti, Mohammed S, Tamagnan, Gilles, Zoghbi, Sami S, Bozkurt, Ali, Baldwin, Ronald M, Innis, Robert B. Influence of acetylcholine levels on the binding of a SPECT nicotinic acetylcholine
receptor ligand [123I]5-I-A-85380. Synapse, 48(3), 116-22, 2003 Fujita, Masahiro, Ichise, Masanori, van Dyck, Christopher H, Zoghbi, Sami S, Tamagnan, Gilles, Mukhin, Alexey G, Bozkurt, Ali, Seneca, Nicholas, Tipre, Dnyanesh, DeNucci, Christopher C, Iida, Hidehiro, Vaupel, D Bruce, Horti, Andrew G, Koren, Andrei O, Kimes, Alane S, London, Edythe D, Seibyl, John P, Baldwin, Ronald M, Innis, Robert B. Quantification of nicotinic acetylcholine receptors in human brain using [123I]5-I-A-85380
SPET. Eur J Nucl Med Mol Imaging, 30(12), 1620-9, 2003 Kugaya, Akira, Sanacora, Gerard, Verhoeff, Nicolaas P L G, Fujita, Masahiro, Mason, Graeme F, Seneca, Nicholas M, Bozkurt, Ali, Khan, Shaukat A, Anand, Amit, Degen, Kathleen, Charney, Dennis S, Zoghbi, Sami S, Baldwin, Ronald M, Seibyl, John P, Innis, Robert B. Cerebral benzodiazepine receptors in depressed patients measured with [123I]iomazenil
SPECT. Biol Psychiatry, 54(8), 792-9, 2003 Kugaya, Akira, Seneca, Nicholas M, Snyder, Peter J, Williams, Stephen A, Malison, Robert T, Baldwin, Ronald M, Seibyl, John P, Innis, Robert B. Changes in human in vivo serotonin and dopamine transporter availabilities
during chronic antidepressant administration. Neuropsychopharmacology, 28(2), 413-20, 2003 Fu, Xing, Tan, Ping-Zhong, Kula, Nora S, Baldessarini, Ross, Tamagnan, Gilles, Innis, Robert B, Baldwin, Ronald M. Synthesis, receptor potency, and selectivity of halogenated diphenylpiperidines
as serotonin 5-HT2A ligands for PET or SPECT brain imaging. J Med Chem, 45(11), 2319-24, 2002 Fujita, Masahiro, Seibyl, John P, Vaupel, D Bruce, Tamagnan, Gilles, Early, Michele, Zoghbi, Sami S, Baldwin, Ronald M, Horti, Andrew G, KoreN, Andrei O, Mukhin, Alexey G, Khan, Shaukat, Bozkurt, Ali, Kimes, Alane S, London, Edythe D, Innis, Robert B. Whole-body biodistribution, radiation absorbed dose, and brain SPET imaging
with [123i]5-i-A-85380 in healthy human subjects. Eur J Nucl Med Mol Imaging, 29(2), 183-90, 2002 Ogier, Lionel, Turpin, Fr??d??ric, Baldwin, Ronald M, Rich??, Fran??oise, Law, Ho, Innis, Robert B, Tamagnan, Gilles. Rearrangement of a mesylate tropane intermediate in nucleophilic substitution
reactions. Synthesis of aza-bicyclo[3.2.1]octane and aza-bicyclo[3.2.2]nonane ethers, imides, and amines. J Org Chem, 67(11), 3637-42, 2002 van Dyck, Christopher H, Quinlan, Donald M, Cretella, Lisa M, Staley, Julie K, Malison, Robert T, Baldwin, Ronald M, Seibyl, John P, Innis, Robert B. Unaltered dopamine transporter availability in adult attention deficit hyperactivity
disorder. Am J Psychiatry, 159(2), 309-12, 2002 van Dyck, Christopher H, Seibyl, John P, Malison, Robert T, Laruelle, Marc, Zoghbi, Sami S, Baldwin, Ronald M, Innis, Robert B. Age-related decline in dopamine transporters: analysis of striatal subregions,
nonlinear effects, and hemispheric asymmetries. Am J Geriatr Psychiatry, 10(1), 36-43, 2002 Soares, J C, van Dyck, C H, Tan, P, Zoghbi, S S, Garg, P, Soufer, R, Baldwin, R M, Fujita, M, Staley, J K, Fu, X, Amici, L, Seibyl, J, Innis, R B. Reproducibility of in vivo brain measures of 5-HT2A receptors with PET and. Psychiatry Res, 106(2), 81-93, 2001 Staley, J K, Van Dyck, C H, Tan, P Z, Al Tikriti, M, Ramsby, Q, Klump, H, Ng, C, Garg, P, Soufer, R, Baldwin, R M, Innis, R B. Comparison of [(18)F]altanserin and [(18)F]deuteroaltanserin for PET imaging
of serotonin(2A) receptors in baboon brain: pharmacological studies. Nucl Med Biol, 28(3), 271-9, 2001 Bremner, JD, Horti, A, Staib, LH, Zea-Ponce, Y, Soufer, R, Charney, DS, Baldwin, R. Kinetic modeling of benzodiazepine receptor binding with PET and high specific
activity [(11)C]Iomazenil in healthy human subjects. Synapse, 35(1), 68-77, 2000 Bremner, JD, Innis, RB, White, T, Fujita, M, Silbersweig, D, Goddard, AW, Staib, L, Stern, E, Cappiello, A, Woods, S, Baldwin, R, Charney, DS. SPECT [I-123]iomazenil measurement of the benzodiazepine receptor in panic
disorder. Biol Psychiatry, 47(2), 96-106, 2000 Castner, SA, al-Tikriti, MS, Baldwin, RM, Seibyl, JP, Innis, RB, Goldman-Rakic, PS. Behavioral changes and [123I]IBZM equilibrium SPECT measurement of amphetamine-induced
dopamine release in rhesus monkeys exposed to subchronic amphetamine. Neuropsychopharmacology, 22(1), 4-13, 2000 Fujita, M, Tamagnan, G, Zoghbi, S S, Al-Tikriti, M S, Baldwin, R M, Seibyl, J P, Innis, R B. Measurement of alpha4beta2 nicotinic acetylcholine receptors with [123I]5-I-A-85380
SPECT. J Nucl Med, 41(9), 1552-60, 2000 Fujita, M, Verhoeff, NP, Varrone, A, Zoghbi, SS, Baldwin, RM, Jatlow, PA, Anderson, GM, Seibyl, JP, Innis, RB. Imaging extrastriatal dopamine D(2) receptor occupancy by endogenous dopamine
in healthy humans. Eur J Pharmacol, 387(2), 179-88, 2000 Scanley, BE, Gandelman, MS, Laruelle, M, Al-Tikriti, MS, Baldwin, RM, Zoghbi, SS, Hoffer, PB, Wang, S, Neumeyer, JL, Innis, RB. [123I]IPCIT and [123I]beta-CIT as SPECT tracers for the dopamine transporter:
a comparative analysis in nonhuman primates. Nucl Med Biol, 27(1), 13-21, 2000 Staley, J K, Tamagnan, G, Baldwin, R M, Fujita, M, Al Tikriti, M S, Eshima, L, Thornback, J, Roe, D, Lu, L, Seibyl, J P, Innis, R B. SPECT imaging with the D(4) receptor antagonist L-750,667 in nonhuman primate
brain. Nucl Med Biol, 27(6), 547-56, 2000 Tamagnan, G, Baldwin, R M, Kula, N S, Baldessarini, R J, Innis, R B. Synthesis and monoamine transporter affinity of 2beta-carbomethoxy-3beta-(2''''-,
3''''- or 4''''-substituted) biphenyltropanes. Bioorg Med Chem Lett, 10(16), 1783-5, 2000 Tamagnan, G, Baldwin, RM, Kula, NS, Baldessarini, RJ, Innis, RB. Cyclopentadienyltricarbonylrheniumbenzazepines: synthesis and binding affinity. Bioorg Med Chem Lett, 10(10), 1113-5, 2000 Varrone, A, Fujita, M, Verhoeff, NP, Zoghbi, SS, Baldwin, RM, Rajeevan, N, Charney, DS, Seibyl, JP, Innis, RB. Test-retest reproducibility of extrastriatal dopamine D2 receptor imaging with
[123I]epidepride SPECT in humans. J Nucl Med, 41(8), 1343-51, 2000 van Dyck CH, , Soares, J C, Tan, P, Staley, J K, Baldwin, R M, Amici, L A, Fu, X, Garg, P K, Seibyl, J P, Charney, D S, Innis, R B. Equilibrium modeling of 5-HT(2A) receptors with [18F]deuteroaltanserin and
PET: feasibility of a constant infusion paradigm. Nucl Med Biol, 27(8), 715-22, 2000 van Dyck, CH, Malison, RT, Seibyl, JP, Laruelle, M, Klumpp, H, Zoghbi, SS, Baldwin, RM, Innis, RB. Age-related decline in central serotonin transporter availability with [(123)I]beta-CIT
SPECT. Neurobiol Aging, 21(4), 497-501, 2000 van Dyck, CH, Tan, PZ, Baldwin, RM, Amici, LA, Garg, PK, Ng, CK, Soufer, R, Charney, DS, Innis, RB. PET quantification of 5-HT2A receptors in the human brain: a constant infusion
paradigm with [18F]altanserin. J Nucl Med, 41(2), 234-41, 2000 Abi-Dargham, A, Laruelle, M, Krystal, J, D''Souza, C, Zoghbi, S, Baldwin, RM, Seibyl, J, Mawlawi, O, de Erasquin, G, Charney, D, Innis, RB. No evidence of altered in vivo benzodiazepine receptor binding in schizophrenia. Neuropsychopharmacology, 20(6), 650-61, 1999 Bremner, JD, Baldwin, R, Horti, A, Staib, LH, Ng, CK, Tan, PZ, Zea-Ponce, Y, Zoghbi, S, Seibyl, JP, Soufer, R, Charney, DS, Innis, RB. Quantitation of benzodiazepine receptor binding with PET [11C]iomazenil and
SPECT [123I]iomazenil: preliminary results of a direct comparison in healthy human subjects. Psychiatry Res, 91(2), 79-91, 1999 Fujita, M, Seibyl, JP, Verhoeff, NP, Ichise, M, Baldwin, RM, Zoghbi, SS, Burger, C, Staley, JK, Rajeevan, N, Charney, DS, Innis, RB. Kinetic and equilibrium analyses of [(123)I]epidepride binding to striatal
and extrastriatal dopamine D(2) receptors. Synapse, 34(4), 290-304, 1999 Fujita, M, Woods, SW, Verhoeff, NP, Abi-Dargham, A, Baldwin, RM, Zoghbi, SS, Soares, JC, Jatlow, PA, Krystal, JH, Rajeevan, N, Charney, DS, Seibyl, JP, Innis, RB. Changes of benzodiazepine receptors during chronic benzodiazepine administration
in humans. Eur J Pharmacol, 368(2-3), 161-72, 1999 Tan, PZ, Baldwin, RM, Soufer, R, Garg, PK, Charney, DS, Innis, RB. A complete remote-control system for reliable preparation of [18F]altanserin. Appl Radiat Isot, 50(5), 923-7, 1999 Tan, PZ, Baldwin, RM, Van Dyck, CH, Al-Tikriti, M, Roth, B, Khan, N, Charney, DS, Innis, RB. Characterization of radioactive metabolites of 5-HT2A receptor PET ligand [18F]altanserin
in human and rodent. Nucl Med Biol, 26(6), 601-8, 1999 Abi-Dargham, A, Gil, R, Krystal, J, Baldwin, RM, Seibyl, JP, Bowers, M, van Dyck, CH, Charney, DS, Innis, RB, Laruelle, M. Increased striatal dopamine transmission in schizophrenia: confirmation in
a second cohort. Am J Psychiatry, 155(6), 761-7, 1998 Abi-Dargham, A, Krystal, JH, Anjilvel, S, Scanley, BE, Zoghbi, S, Baldwin, RM, Rajeevan, N, Ellis, S, Petrakis, IL, Seibyl, JP, Charney, DS, Laruelle, M, Innis, RB. Alterations of benzodiazepine receptors in type II alcoholic subjects measured
with SPECT and [123I]iomazenil. Am J Psychiatry, 155(11), 1550-5, 1998 Malison, RT, Best, SE, van Dyck, CH, McCance, EF, Wallace, EA, Laruelle, M, Baldwin, RM, Seibyl, JP, Price, LH, Kosten, TR, Innis, RB. Elevated striatal dopamine transporters during acute cocaine abstinence as
measured by [123I] beta-CIT SPECT. Am J Psychiatry, 155(6), 832-4, 1998 Malison, RT, McCance, E, Carpenter, LL, Baldwin, RM, Seibyl, JP, Price, LH, Kosten, TR, Innis, RB. [123I]beta-CIT SPECT imaging of dopamine transporter availability after mazindol
administration in human cocaine addicts. Psychopharmacology (Berl), 137(4), 321-5, 1998 Malison, RT, Price, LH, Berman, R, van Dyck, CH, Pelton, GH, Carpenter, L, Sanacora, G, Owens, MJ, Nemeroff, CB, Rajeevan, N, Baldwin, RM, Seibyl, JP, Innis, RB, Charney, DS. Reduced brain serotonin transporter availability in major depression as measured
by [123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane and single photon emission computed tomography. Biol Psychiatry, 44(11), 1090-8, 1998 Seibyl, JP, Marek, K, Sheff, K, Zoghbi, S, Baldwin, RM, Charney, DS, van Dyck, CH, Innis, RB. Iodine-123-beta-CIT and iodine-123-FPCIT SPECT measurement of dopamine transporters
in healthy subjects and Parkinson''s patients. J Nucl Med, 39(9), 1500-8, 1998 Abi-Dargham, A, Innis, RB, Wisniewski, G, Baldwin, RM, Neumeyer, JL, Seibyl, JP. Human biodistribution and dosimetry of iodine-123-fluoroalkyl analogs of beta-CIT. Eur J Nucl Med, 24(11), 1422-5, 1997 Abi-Dargham, A, Zea-Ponce, Y, Terriere, D, al-Tikriti, M, Baldwin, RM, Hoffer, P, Charney, D, Leysen, JE, Laruelle, M, Mertens, J, Innis, RB. Preclinical evaluation of [123I]R93274 as a SPECT radiotracer for imaging 5-HT2A
receptors. Eur J Pharmacol, 321(3), 285-93, 1997 Laruelle, M, D''Souza, CD, Baldwin, RM, Abi-Dargham, A, Kanes, SJ, Fingado, CL, Seibyl, JP, Zoghbi, SS, Bowers, MB, Jatlow, P, Charney, DS, Innis, RB. Imaging D2 receptor occupancy by endogenous dopamine in humans. Neuropsychopharmacology, 17(3), 162-74, 1997 Laruelle, M, Iyer, RN, al-Tikriti, MS, Zea-Ponce, Y, Malison, R, Zoghbi, SS, Baldwin, RM, Kung, HF, Charney, DS, Hoffer, PB, Innis, RB, Bradberry, CW. Microdialysis and SPECT measurements of amphetamine-induced dopamine release
in nonhuman primates. Synapse, 25(1), 1-14, 1997 Seibyl, JP, Marek, K, Sheff, K, Baldwin, RM, Zoghbi, S, Zea-Ponce, Y, Charney, DS, van Dyck, CH, Hoffer, PB, Innis, RB. Test/retest reproducibility of iodine-123-betaCIT SPECT brain measurement of
dopamine transporters in Parkinson''s patients. J Nucl Med, 38(9), 1453-9, 1997 Zea-Ponce, Y, Baldwin, RM, Stratton, MD, al-Tikriti, M, Soufer, R, Schaus, JM, Innis, RB. Radiosynthesis and PET imaging of [N-methyl-11C]LY257327 as a tracer for 5-HT
transporters. Nucl Med Biol, 24(3), 251-4, 1997 Abi-Dargham, A, Gandelman, MS, DeErausquin, GA, Zea-Ponce, Y, Zoghbi, SS, Baldwin, RM, Laruelle, M, Charney, DS, Hoffer, PB, Neumeyer, JL, Innis, RB. SPECT imaging of dopamine transporters in human brain with iodine-123-fluoroalkyl
analogs of beta-CIT. J Nucl Med, 37(7), 1129-33, 1996 Laruelle, M, Abi-Dargham, A, van Dyck, CH, Gil, R, D''Souza, CD, Erdos, J, McCance, E, Rosenblatt, W, Fingado, C, Zoghbi, SS, Baldwin, RM, Seibyl, JP, Krystal, JH, Charney, DS, Innis, RB. Single photon emission computerized tomography imaging of amphetamine-induced
dopamine release in drug-free schizophrenic subjects. Proc Natl Acad Sci U S A, 93(17), 9235-40, 1996 Marek, KL, Seibyl, JP, Zoghbi, SS, Zea-Ponce, Y, Baldwin, RM, Fussell, B, Charney, DS, van Dyck, C, Hoffer, PB, Innis, RP. [123I] beta-CIT/SPECT imaging demonstrates bilateral loss of dopamine transporters
in hemi-Parkinson''s disease. Neurology, 46(1), 231-7, 1996 Seibyl, JP, Laruelle, M, van Dyck, CH, Wallace, E, Baldwin, RM, Zoghbi, S, Zea-Ponce, Y, Neumeyer, JL, Charney, DS, Hoffer, PB, Innis, RB. Reproducibility of iodine-123-beta-CIT SPECT brain measurement of dopamine
transporters. J Nucl Med, 37(2), 222-8, 1996 Seibyl, JP, Zea-Ponce, Y, Brenner, L, Baldwin, RM, Krystal, JH, Offord, SJ, Mochoviak, S, Charney, DS, Hoffer, PB, Innis, RB. Continuous intravenous infusion of iodine-123-IBZM for SPECT determination
of human brain dopamine receptor occupancy by antipsychotic agent RWJ-37796. J Nucl Med, 37(1), 11-5, 1996 van Dyck, CH, Seibyl, JP, Stubbs, JB, Zoghbi, S, Wisniewski, G, Baldwin, RM, Zea-Ponce, Y, Charney, DS, Hoffer, PB, Innis, RB. Human biodistribution and dosimetry of the SPECT D2 dopamine receptor radioligand
[123I]IBF. Nucl Med Biol, 23(1), 9-16, 1996 Abi-Dargham, A, Gandelman, M, Zoghbi, SS, Laruelle, M, Baldwin, RM, Randall, P, Zea-Ponce, Y, Charney, DS, Hoffer, PB, Innis, RB. Reproducibility of SPECT measurement of benzodiazepine receptors in human brain
with iodine-123-iomazenil. J Nucl Med, 36(2), 167-75, 1995 Baldwin, RM, Horti, AG, Bremner, JD, Stratton, MD, Dannals, RF, Ravert, HT, Zea-Ponce, Y, Ng, CK, Dey, HM, Soufer, R. Synthesis and PET imaging of the benzodiazepine receptor tracer [N-methyl-11C]iomazenil. Nucl Med Biol, 22(5), 659-65, 1995 Baldwin, RM, Zea-Ponce, Y, al-Tikriti, MS, Zoghbi, SS, Seibyl, JP, Charney, DS, Hoffer, PB, Wang, S, Milius, RA, Neumeyer, JL. Regional brain uptake and pharmacokinetics of [123I]N-omega-fluoroalkyl-2 beta-carboxy-3
beta-(4-iodophenyl)nortropane esters in baboons. Nucl Med Biol, 22(2), 211-9, 1995 Laruelle, M, Abi-Dargham, A, van Dyck, CH, Rosenblatt, W, Zea-Ponce, Y, Zoghbi, SS, Baldwin, RM, Charney, DS, Hoffer, PB, Kung, HF. SPECT imaging of striatal dopamine release after amphetamine challenge. J Nucl Med, 36(7), 1182-90, 1995 Malison, RT, McDougle, CJ, van Dyck, CH, Scahill, L, Baldwin, RM, Seibyl, JP, Price, LH, Leckman, JF, Innis, RB. [123I]beta-CIT SPECT imaging of striatal dopamine transporter binding in Tourette''s
disorder. Am J Psychiatry, 152(9), 1359-61, 1995 Scanley, BE, al-Tikriti, MS, Gandelman, MS, Laruelle, M, Zea-Ponce, Y, Baldwin, RM, Zoghbi, SS, Hoffer, PB, Charney, DS, Wang, S. Comparison of [123I]beta-CIT and [123I]IPCIT as single-photon emission tomography
radiotracers for the dopamine transporter in nonhuman primates. Eur J Nucl Med, 22(1), 4-11, 1995 Seibyl, JP, Marek, KL, Quinlan, D, Sheff, K, Zoghbi, S, Zea-Ponce, Y, Baldwin, RM, Fussell, B, Smith, EO, Charney, DS. Decreased single-photon emission computed tomographic [123I]beta-CIT striatal
uptake correlates with symptom severity in Parkinson''s disease. Ann Neurol, 38(4), 589-98, 1995 Zea-Ponce, Y, Baldwin, RM, Laruelle, M, Wang, S, Neumeyer, JL, Innis, RB. Simplified multidose preparation of iodine-123-beta-CIT: a marker for dopamine
transporters. J Nucl Med, 36(3), 525-9, 1995 al-Tikriti, MS, Zea-Ponce, Y, Baldwin, RM, Zoghbi, SS, Laruelle, M, Seibyl, JP, Giddings, SS, Scanley, BE, Charney, DS, Hoffer, PB. Characterization of the dopamine transporter in nonhuman primate brain: homogenate
binding, whole body imaging, and ex vivo autoradiography using [125I] and [123I]IPCIT. Nucl Med Biol, 22(5), 649-58, 1995 van Dyck, CH, Seibyl, JP, Malison, RT, Laruelle, M, Wallace, E, Zoghbi, SS, Zea-Ponce, Y, Baldwin, RM, Charney, DS, Hoffer, PB. Age-related decline in striatal dopamine transporter binding with iodine-123-beta-CITSPECT. J Nucl Med, 36(7), 1175-81, 1995 Abi-Dargham, A, Laruelle, M, Seibyl, J, Rattner, Z, Baldwin, RM, Zoghbi, SS, Zea-Ponce, Y, Bremner, JD, Hyde, TM, Charney, DS. SPECT measurement of benzodiazepine receptors in human brain with iodine-123-iomazenil:
kinetic and equilibrium paradigms. J Nucl Med, 35(2), 228-38, 1994 Baldwin, RM, Zea-Ponce, Y, Zoghbi, SS, al-Tikriti, MS, Seibyl, JP, Sybirska, EH, Malison, RT, Laruelle, M, Charney, DS, Hoffer, PB. Pharmacokinetics of the three radioiodinated dopamine D2 receptor ligands [123I]IBF,
[123I]epidepride and [123I]2''-ISP in nonhuman primates. Nucl Med Biol, 21(7), 969-76, 1994 Gandelman, MS, Baldwin, RM, Zoghbi, SS, Zea-Ponce, Y, Innis, RB. Evaluation of ultrafiltration for the free-fraction determination of single
photon emission computed tomography (SPECT) radiotracers: beta-CIT, IBF, and iomazenil. J Pharm Sci, 83(7), 1014-9, 1994 Laruelle, M, Abi-Dargham, A, al-Tikriti, MS, Baldwin, RM, Zea-Ponce, Y, Zoghbi, SS, Charney, DS, Hoffer, PB, Innis, RB. SPECT quantification of [123I]iomazenil binding to benzodiazepine receptors
in nonhuman primates: II. Equilibrium analysis of constant infusion experiments and correlation with
in vitro parameters. J Cereb Blood Flow Metab, 14(3), 453-65, 1994 Laruelle, M, Baldwin, RM, Innis, RB. SPECT imaging of dopamine and serotonin transporters in nonhuman primate brain. NIDA Res Monogr, 138, 131-59, 1994 Laruelle, M, Baldwin, RM, Rattner, Z, al-Tikriti, MS, Zea-Ponce, Y, Zoghbi, SS, Charney, DS, Price, JC, Frost, JJ, Hoffer, PB. SPECT quantification of [123I]iomazenil binding to benzodiazepine receptors
in nonhuman primates: I. Kinetic modeling of single bolus experiments. J Cereb Blood Flow Metab, 14(3), 439-52, 1994 Laruelle, M, Giddings, SS, Zea-Ponce, Y, Charney, DS, Neumeyer, JL, Baldwin, RM, Innis, RB. Methyl 3 beta-(4-[125I]iodophenyl)tropane-2 beta-carboxylate in vitro binding
to dopamine and serotonin transporters under "physiological" conditions. J Neurochem, 62(3), 978-86, 1994 Laruelle, M, Wallace, E, Seibyl, JP, Baldwin, RM, Zea-Ponce, Y, Zoghbi, SS, Neumeyer, JL, Charney, DS, Hoffer, PB, Innis, RB. Graphical, kinetic, and equilibrium analyses of in vivo [123I] beta-CIT binding
to dopamine transporters in healthy human subjects. J Cereb Blood Flow Metab, 14(6), 982-94, 1994 Laruelle, M, al-Tikriti, MS, Zea-Ponce, Y, Zoghbi, SS, Baldwin, RM, Charney, DS, Hoffer, PB, Kung, HF, Innis, RB. In vivo quantification of dopamine D2 receptor parameters in nonhuman primates
with [123I]iodobenzofuran and single photon emission computerized tomography. Eur J Pharmacol, 263(1-2), 39-51, 1994 Laruelle, M, van Dyck, C, Abi-Dargham, A, Zea-Ponce, Y, Zoghbi, SS, Charney, DS, Baldwin, RM, Hoffer, PB, Kung, HF, Innis, RB. Compartmental modeling of iodine-123-iodobenzofuran binding to dopamine D2
receptors in healthy subjects. J Nucl Med, 35(5), 743-54, 1994 Scanley, BE, Baldwin, RM, Laruelle, M, al-Tikriti, MS, Zea-Ponce, Y, Zoghbi, S, Giddings, SS, Charney, DS, Hoffer, PB, Wang, S. Active and inactive enantiomers of 2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane:
comparison using homogenate binding and single photon emission computed tomographic imaging. Mol Pharmacol, 45(1), 136-41, 1994 Seibyl, JP, Wallace, E, Smith, EO, Stabin, M, Baldwin, RM, Zoghbi, S, Zea-Ponce, Y, Gao, Y, Zhang, WY, Neumeyer, JL. Whole-body biodistribution, radiation absorbed dose and brain SPECT imaging
with iodine-123-beta-CIT in healthy human subjects. J Nucl Med, 35(5), 764-70, 1994 Zea-Ponce, Y, Baldwin, RM, Zoghbi, SS, Innis, RB. Formation of 1-[123I]iodobutane in labeling [123I]iomazenil by iododestannylation:
implications for the reaction mechanism. Appl Radiat Isot, 45(1), 63-8, 1994 al-Tikriti, MS, Baldwin, RM, Zea-Ponce, Y, Sybirska, E, Zoghbi, SS, Laruelle, M, Malison, RT, Kung, HF, Kessler, RM, Charney, DS. Comparison of three high affinity SPECT radiotracers for the dopamine D2 receptor. Nucl Med Biol, 21(2), 179-88, 1994 al-Tikriti, MS, Dey, HM, Zoghbi, SS, Baldwin, RM, Zea-Ponce, Y, Innis, RB. Dual-isotope autoradiographic measurement of regional blood flow and benzodiazepine
receptor availability following unilateral middle cerebral artery occlusion. Eur J Nucl Med, 21(3), 196-202, 1994 Baldwin, RM, Zea-Ponce, Y, Zoghbi, SS, Laurelle, M, al-Tikriti, MS, Sybirska, EH, Malison, RT, Neumeyer, JL, Milius, RA, Wang, S. Evaluation of the monoamine uptake site ligand [123I]methyl 3 beta-(4-iodophenyl)-tropane-2
beta-carboxylate ([123I]beta-CIT) in non-human primates: pharmacokinetics, biodistribution and SPECT
brain imaging coregistered with MRI. Nucl Med Biol, 20(5), 597-606, 1993 Innis, RB, Seibyl, JP, Scanley, BE, Laruelle, M, Abi-Dargham, A, Wallace, E, Baldwin, RM, Zea-Ponce, Y, Zoghbi, S, Wang, S. Single photon emission computed tomographic imaging demonstrates loss of striatal
dopamine transporters in Parkinson disease. Proc Natl Acad Sci U S A, 90(24), 11965-9, 1993 Laruelle, M, Baldwin, RM, Malison, RT, Zea-Ponce, Y, Zoghbi, SS, al-Tikriti, MS, Sybirska, EH, Zimmermann, RC, Wisniewski, G, Neumeyer, JL. SPECT imaging of dopamine and serotonin transporters with [123I]beta-CIT: pharmacological
characterization of brain uptake in nonhuman primates. Synapse, 13(4), 295-309, 1993 McBride, BJ, Baldwin, RM, Kerr, JM, Wu, JL, Schultze, LM, Salazar, NE, Chinitz, JM, Byrne, EF. Structure-activity relationship of 99mTc complexes of phenylenediamine-thiol-thioether
ligands (PhAT) to brain uptake in rats. J Med Chem, 36(1), 81-6, 1993 Sybirska, E, Seibyl, JP, Bremner, JD, Baldwin, RM, al-Tikriti, MS, Bradberry, C, Malison, RT, Zea-Ponce, Y, Zoghbi, S, During, M. [123I]iomazenil SPECT imaging demonstrates significant benzodiazepine receptor
reserve in human and nonhuman primate brain. Neuropharmacology, 32(7), 671-80, 1993 Johnson, EW, de Lanerolle, NC, Kim, JH, Sundaresan, S, Spencer, DD, Mattson, RH, Zoghbi, SS, Baldwin, RM, Hoffer, PB, Seibyl, JP. "Central" and "peripheral" benzodiazepine receptors: opposite changes in human
epileptogenic tissue. Neurology, 42(4), 811-5, 1992 Seibyl, JP, Woods, SW, Zoghbi, SS, Baldwin, RM, Dey, HM, Goddard, AW, Zea-Ponce, Y, Zubal, G, Germine, M, Smith, EO. Dynamic SPECT imaging of dopamine D2 receptors in human subjects with iodine-123-IBZM. J Nucl Med, 33(11), 1964-71, 1992 Sybirska, E, al-Tikriti, M, Zoghbi, SS, Baldwin, RM, Johnson, EW, Innis, RB. SPECT imaging of the benzodiazepine receptor: autoradiographic comparison of
receptor density and radioligand distribution. Synapse, 12(2), 119-28, 1992 Woods, SW, Seibyl, JP, Goddard, AW, Dey, HM, Zoghbi, SS, Germine, M, Baldwin, RM, Smith, EO, Charney, DS, Heninger, GR. Dynamic SPECT imaging after injection of the benzodiazepine receptor ligand
[123I]iomazenil in healthy human subjects. Psychiatry Res, 45(2), 67-77, 1992 Zoghbi, SS, Baldwin, RM, Seibyl, JP, al-Tikriti, MS, Zea-Ponce, Y, Laruelle, M, Sybirska, EH, Woods, SW, Goddard, AW, Malison, RT. Pharmacokinetics of the SPECT benzodiazepine receptor radioligand [123I]iomazenil
in human and non-human primates. Int J Rad Appl Instrum B, 19(8), 881-8, 1992 Innis, R, Baldwin, R, Sybirska, E, Zea, Y, Laruelle, M, al-Tikriti, M, Charney, D, Zoghbi, S, Smith, E, Wisniewski, G. Single photon emission computed tomography imaging of monoamine reuptake sites
in primate brain with [123I]CIT. Eur J Pharmacol, 200(2-3), 369-70, 1991 Innis, RB, al-Tikriti, MS, Zoghbi, SS, Baldwin, RM, Sybirska, EH, Laruelle, MA, Malison, RT, Seibyl, JP, Zimmermann, RC, Johnson, EW. SPECT imaging of the benzodiazepine receptor: feasibility of in vivo potency
measurements from stepwise displacement curves. J Nucl Med, 32(9), 1754-61, 1991 Macwhorter, SE, Baldwin, RM. Synthesis and biodistribution of 123I N-(2-aminoethyl)-5-iodo-2-pyridinecarboxamide
(Ro 43-0463), a monoamine oxidase B inhibitor. Int J Rad Appl Instrum B, 18(5), 563-4, 1991 Baldwin, RM, Wu, JL. In vivo chemistry of iofetamine HCl iodine-123 (IMP). J Nucl Med, 29(1), 122-4, 1988 |
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