H. Charles Manning, Ph.D.

Position: Assistant Professor

Department: Radiology and Radiological Sciences

Lab Url: N/A

Email: henry.c.manning@vanderbilt.edu

Office Address: 1161 21st Avenue South
Office Address2: MCN AA-1105
Nashville , TN 37232-2310
Phone :(615) 322-3793
Fax: (615) 322-0734

Lab Address: AAA-3115 Medical Center North/VUIIS


H. Charles Manning's picture
  H. Charles Manning, Ph.D.
Patient Care Specialty
Molecular imaging, angiogenesis, imaging probe discovery/development, high-throughput screening (HTS),Apoptosis,Cancer,Cell cycle,Molecular medicine,Neuroscience

Research Specialty
Molecular imaging, chemistry, small-molecule discovery, therapeutic efficacy screening, clinical trial modeling, imaging probe development, imaging validation

Research Description
Our multi-disciplinary research program involves the development, validation, and translation of non-invasive molecular imaging metrics to assess disease progression and response to therapy. Projects within our program emphasize molecular imaging of cancer, and notably imaging-based assessment of response to anti-cancer pharmaceuticals in colorectal and breast cancer. We are actively engaged in advancing novel methods to image molecular events in both humans and animal models that include receptor expression, proliferation, angiogenesis, and apoptosis. Among these methods include validation of imaging probes for novel applications, as well as high-throughput small-molecule discovery to develop novel imaging compounds.

Publications
Manning, HC, Shay, SD, Mericle, RA. Multispectral molecular imaging of capillary endothelium to facilitate preoperative endovascular brain mapping. J Neurosurg, , , 2009

Shah, C, Miller, TW, Wyatt, SK, McKinley, ET, Olivares, MG, Sanchez, V, Nolting, DD, Buck, JR, Zhao, P, Ansari, MS, Baldwin, RM, Gore, JC, Schiff, R, Arteaga, CL, Manning, HC. Imaging biomarkers predict response to anti-HER2 (ErbB2) therapy in preclinical models of breast cancer. Clin Cancer Res, 15(14), 4712-21, 2009

Virostko, J, Xie, J, Hallahan, DE, Arteaga, CL, Gore, JC, Manning, HC. A Molecular Imaging Paradigm to Rapidly Profile Response to Angiogenesis-directed Therapy in Small Animals. Mol Imaging Biol, , , 2009

H. Charles Manning. Optical imaging shines in vivo. Journal of Nuclear Medicine, 49, 23N-29N, 2008

Manning, HC, Lander, A, McKinley, E, Mutic, NJ. Accelerating the Development of Novel Molecular Imaging Probes: A Role for High-Throughput Screening. J Nucl Med, , , 2008

Manning, HC, Merchant, NB, Foutch, AC, Virostko, JM, Wyatt, SK, Shah, C, McKinley, ET, Xie, J, Mutic, NJ, Washington, MK, Lafleur, B, Tantawy, MN, Peterson, TE, Ansari, MS, Baldwin, RM, Rothenberg, ML, Bornhop, DJ, Gore, JC, Coffey, RJ. Molecular Imaging of Therapeutic Response to Epidermal Growth Factor Receptor Blockade in Colorectal Cancer. Clin Cancer Res, 14(22), 7413-7422, 2008

Deane, NG, Manning, HC, Foutch, AC, Washington, MK, Aronow, BA, Bornhop, DJ, Coffey, RJ. Targeted imaging of colonic tumors in smad3-/- mice discriminates cancer and inflammation. Mol Cancer Res, 5(4), 341-9, 2007

Manning, HC, Smith, SM, Sexton, M, Haviland, S, Bai, M, Cederquist, K, Stella, N, Bornhop, DJ. A peripheral benzodiazepine receptor targeted agent for in vitro imaging and screening. Bioconjug Chem, 17(3), 735-40, 2006

Manning, HC., Bai, M., Anderson, BM., Lisiak, R., Samuelson, L., Bornhop, D.J. Expeditious synthesis of P-Protected macrocycles in-route to lanthanide chelate metal complexes. Tetrahedron Letters, 46, 4707-4710, 2005

Smentek, L, Andes Hess, B, Cross, JP, Charles Manning, H, Bornhop, DJ. Density-functional theory structures of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid complexes for ions across the lanthanide series. J Chem Phys, 123(24), 244302, 2005

Manning, HC, Goebel, T, Thompson, RC, Price, RR, Lee, H, Bornhop, DJ. Targeted molecular imaging agents for cellular-scale bimodal imaging. Bioconjug Chem, 15(6), 1488-95, 2004

Manning, HC., Skwierawska, A., Marx, JN., et al. Rapid removal of benzyloxycarbonyl groups from 1,4,7,10-tetraazacyclododecane derivatives by catalytic transfer hydrogenation. Synthetic Communications, 33(3), 457-461, 2003

Marcu, L., Vernier, T., Manning, H.C., Salemi, S., Li, A., Craft, C., Gundersen, M., Bornhop, D. Fluorescence microscopy studies of a peripheral-benzodiazepine-receptor-targeted molecular probe for brain tumor imaging.. Proceedings of SPIE-The International Society for Optical Engineering, 5141, 64-69, 2003

Manning, HC, Goebel, T, Marx, JN, Bornhop, DJ. Facile, efficient conjugation of a trifunctional lanthanide chelate to a peripheral benzodiazepine receptor ligand. Org Lett, 4(7), 1075-8, 2002

Griffin, JMM., Skwierawska, AM., Manning, HC., Marx, JN., Bornhop, DJ. Simple, high-yielding synthesis of trifunctional fluorescent lanthanide chelates. Tetrahedron Letters, 42, 3823-3825, 2001

Postdoctoral Position Available
Yes

Postdoctoral Position Details
N/A

Updated Date
03/04/2009

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Last Modified: June 29, 2007
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