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Imaging mass spectrometry uses a laser to probe the molecules in tissue samples, such as mouse brain slices. It produces images showing new molecular views ó colors indicate the locations of different proteins.

$10 million grant bolsters molecular imaging resource

BY: LEIGH MACMILLAN

3/31/2011 - The National Center for Research Resources has awarded Vanderbilt University $10.3 million over the next five years to establish a National Research Resource for Imaging Mass Spectrometry.

Richard Caprioli, Ph.D., director of Vanderbilt's Mass Spectrometry Research Center, is leading the program.

Richard Caprioli, Ph.D.

Richard Caprioli, Ph.D.

Imaging mass spectrometry is a tool for visualizing the location of proteins in cells and tissues. It can be used to “follow” the molecular changes that cause disease, which is “vital to our understanding of how to treat a patient to stabilize, reverse and even eliminate disease processes,” said Caprioli, the Stanley Cohen Professor of Biochemistry and professor of Chemistry, Medicine and Pharmacology.

Caprioli has pioneered imaging mass spectrometry techniques and expects the new Research Resource to move this technology from the instrumental development laboratory to the biological and clinical research laboratory as a routine imaging tool.

“Imaging mass spectrometry gives the research scientist and the physician a new and unprecedented view of the molecular changes underlying disease processes,” Caprioli said.

The National Research Resource for Imaging Mass Spectrometry will focus on developing new technologies — next generation hardware, software and methods — for direct tissue profiling and imaging using mass spectrometry.

New biological applications will include high spatial resolution imaging of serotonin neurons in neurodevelopmental disorders, studies of cervical and brain cancers, studies of age-related macular degeneration and studies of tumor blood vessel development.

The resource will support short training courses and scientific visits to encourage collaborations.

The molecular view offered by imaging mass spectrometry will offer a new understanding of the biology of health and disease that will lead to novel treatment opportunities for patients, Caprioli said.

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