RESEARCH AREAS

Preimplantation Embryo Development and Implantation Steroid Hormones and Environmental Mimics Growth Factors and Cytokine Signaling Vascular Permeability and Angiogenesis Prostaglandin Signaling Cell Cycle Regulation in Implantation Endocannabinoid Signaling Emerging Concepts

CELL CYCLE REGULATION IN IMPLANTATION
Uterine decidualization involves the transformation of uterine stromal cells around the implanting blastocyst and includes regulated cell cycle activities, including endoreduplication and polyploidy. The following papers reflect one of the newest areas of research in our laboratories.

Tan J, Raja S, Davis MK, Tawfik O, Dey SK, Das SK.
Evidence for coordinated interaction of cyclin D3 with p21 and cdk6 in directing the development of uterine stromal cell decidualization and polyploidy during implantation.
Mech Dev. 2002 Feb;111(1-2):99-113.


Das SK, Lim H, Paria BC, Dey SK.
Cyclin D3 in the mouse uterus is associated with the decidualization process during early pregnancy.
J Mol Endocrinol. 1999 Feb;22(1):91-101.

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