The Division of Reproductive and Developmental Biology Department of Pediatrics at Vanderbilt University Medical Center VU Help Search Vanderbilt Medical Center Sanjoy K. Das, Ph.D Bibhash C. Paria, Ph.D S. K. Dey, Ph.D
The Division of Reproductive and Developmental Biology



Home
What's New
Research Areas
Investigators
Links Contact Us
R.B. Training Grant


Understanding the complex interactions between the embryo and uterus during pregnancy is essential for alleviating the problems of infertility, ensuring the birth of healthy offspring, and developing improved contraceptives. The following publications highlight what's new in our labs and reflect our most recent effots to elucidate the molecular mechanisms of reproduction.

CLICK HERE TO VIEW OUR COVER ARTICLES

Deb K, Reese J, Paria BC.
Methodologies to study implantation in mice.
Methods Mol Med. 2006;121:9-34.

Tranguch S, Cheung-Flynn J, Daikoku T, Prapapanich V, Cox MB, Xie H, Wang H, Das SK, Smith DF, Dey SK.
Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation.
Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14326-31. Epub 2005 Sep 21.

Wang H, Dey SK.
Lipid signaling in embryo implantation.
Prostaglandins Other Lipid Mediat. 2005 Sep;77(1-4):84-102.

Rapaka RS, Hla T, Dey SK.
The dawn of lipidomics.
Prostaglandins Other Lipid Mediat. 2005 Sep;77(1-4):1-3.

Wang H, Tranguch S, Xie H, Hanley G, Das SK, Dey SK.
Variation in commercial rodent diets induces disparate molecular and physiological changes in the mouse uterus.
Proc Natl Acad Sci U S A. 2005 Jul 12;102(28):9960-5. Epub 2005 Jun 29.

Guo Y, Wang H, Okamoto Y, Ueda N, Kingsley PJ, Marnett LJ, Schmid HH, Das SK, Dey SK.
N-acylphosphatidylethanolamine-hydrolyzing phospholipase D is an important determinant of uterine anandamide levels during implantation.
J Biol Chem. 2005 Jun 24;280(25):23429-32. Epub 2005 May 12.

Dey SK.
Reproductive biology: fatty link to fertility.
Nature. 2005 May 5;435(7038):34-5.

Daikoku T, Wang D, Tranguch S, Morrow JD, Orsulic S, DuBois RN, Dey SK.
Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer.
Cancer Res. 2005 May 1;65(9):3735-44.

Wang D, Buchanan FG, Wang H, Dey SK, DuBois RN.
Prostaglandin E2 enhances intestinal adenoma growth via activation of the Ras-mitogen-activated protein kinase cascade.
Cancer Res. 2005 Mar 1;65(5):1822-9.

Yue L, Daikoku T, Hou X, Li M, Wang H, Nojima H, Dey SK, Das SK.
Cyclin G1 and cyclin G2 are expressed in the periimplantation mouse uterus in a cell-specific and progesterone-dependent manner: evidence for aberrant regulation with Hoxa-10 deficiency.
Endocrinology. 2005 May;146(5):2424-33. Epub 2005 Jan 20.

Daikoku T, Tranguch S, Friedman DB, Das SK, Smith DF, Dey SK.
Proteomic analysis identifies immunophilin FK506 binding protein 4 (FKBP52) as a downstream target of Hoxa10 in the periimplantation mouse uterus.
Mol Endocrinol. 2005 Mar;19(3):683-97. Epub 2004 Nov 4.

Thadani PV, Strauss JF 3rd, Dey SK, Anderson VM, Audus KL, Coats KS, Cross JC, Erlebacher A, Ganapathy V, Linzer DI, Miller RK, Novak DA, Rapaka RS, Sadovsky Y, Salafia CM, Soares M, Unadkat J.
National Institute on Drug Abuse Conference report on placental proteins, drug transport, and fetal development.
Am J Obstet Gynecol. 2004 Dec;191(6):1858-62. Review.

Dey SK.
Focus on implantation.
Reproduction. 2004 Dec;128(6):655-6.

Brown N, Deb K, Paria BC, Das SK, Reese J.
Embryo-uterine interactions via the neuregulin family of growth factors during implantation in the mouse.
Biol Reprod. 2004 Dec;71(6):2003-11. Epub 2004 Aug 11.

Andrews GK, Wang H, Dey SK, Palmiter RD.
Mouse zinc transporter 1 gene provides an essential function during early embryonic development.
Genesis. 2004 Oct;40(2):74-81.

Wang D, Wang H, Shi Q, Katkuri S, Walhi W, Desvergne B, Das SK, Dey SK, DuBois RN.
Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta.
Cancer Cell. 2004 Sep;6(3):285-95.

Wang H, Guo Y, Wang D, Kingsley PJ, Marnett LJ, Das SK, DuBois RN, Dey SK.
Aberrant cannabinoid signaling impairs oviductal transport of embryos.
Nat Med. 2004 Oct;10(10):1074-80. Epub 2004 Sep 19. Erratum in: Nat Med. 2004 Dec;10(12):1397.

Hou X, Tan Y, Li M, Dey SK, Das SK.
Canonical Wnt signaling is critical to estrogen-mediated uterine growth.
Mol Endocrinol. 2004 Dec;18(12):3035-49. Epub 2004 Sep 9.

Rouzer CA, Kingsley PJ, Wang H, Zhang H, Morrow JD, Dey SK, Marnett LJ.
Cyclooxygenase-1-dependent prostaglandin synthesis modulates tumor necrosis factor-alpha secretion in lipopolysaccharide-challenged murine resident peritoneal macrophages.
J Biol Chem. 2004 Aug 13;279(33):34256-68. Epub 2004 Jun 4.

Wang X, Su Y, Deb K, Raposo M, Morrow JD, Reese J, Paria BC.
Prostaglandin E2 is a product of induced prostaglandin-endoperoxide synthase 2 and microsomal-type prostaglandin E synthase at the implantation site of the hamster.
J Biol Chem. 2004 Jul 16;279(29):30579-87. Epub 2004 Apr 12.

Daikoku T, Song H, Guo Y, Riesewijk A, Mosselman S, Das SK, Dey SK.
Uterine Msx-1 and Wnt4 signaling becomes aberrant in mice with the loss of leukemia inhibitory factor or Hoxa-10: Evidence for a novel cytokine-homeobox-Wnt signaling in implantation.
Mol Endocrinol. 2004 May;18(5):1238-50. Epub 2004 Feb 19.

Gupta RA, Wang D, Katkuri S, Wang H, Dey SK, DuBois RN.
Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth.
Nat Med. 2004 Mar;10(3):245-7. Epub 2004 Feb 01.

Tan Y, Li M, Cox S, Davis MK, Tawfik O, Paria BC, Das SK.
HB-EGF directs stromal cell polyploidy and decidualization via cyclin D3 during implantation.
Dev Biol. 2004 Jan 1;265(1):181-95.

Wang H, Ma WG, Tejada L, Zhang H, Morrow JD, Das SK, Dey SK
Rescue of female infertility from the loss of cyclooxygenase-2 by compensatory upregulation of cyclooxygenase-1 is a function of genentic background.
J Biol Chem. 2003 Dec 29

Wang H, Matsumoto H, Guo Y, Paria BC, Roberts RL, Dey SK
Differential G protein-coupled cannabinoid receptor signaling by anandamide directs blastocyst activation for implantation.
Proc Natl Acad Sci USA. 2003 Dec 9; 100(25):14914-9. Epud 2003 Nov 26.

Wang X, Matsumoto H, Zhao X, Das SK, Paria BC.
Embryonic signals direct the formation of tight junctional permeability barrier in the decidualizing stroma during embryo implantation.
J Cell Sci. 2004 Jan 1;117(Pt 1):53-62. Epub 2003 Nov 19.

Matsumoto H, Daikoku T, Wang H, Sato E, Dey SK.
Differential expression of Ezrin/Radixin/Moesin(ERM) and ERM-Associated during implantation.
Bio Reprod. 2003 Nov 12.

Gao L, Zackert WE, Hasford JJ, Danekis ME, Milne GL, Remmert C, Reese J, Yin H, Tai HH, Dey SK, Porter NA, Morrow JD.
Formation of prostaglandins E2 and D2 via the isoprostane pathway: a mechanism for the generation of bioactive prostoglandins independent of cyclooxygenase.
J Biol Chem. 2003 Aug 1;278(31):28479-89. Epub 2003 May 13.

Wang X, Wang H, Matsumoto H, Roy SK, Das SK, Paria BC
Dual source and target of heparin-binding EGF-like growth factor during the onset of implantation in the hamster.
Development. 2002 Sep;129(17):4125-34.


Gupta RA, Tejada LV, Tong BJ, Das SK, Morrow JD, Dey SK, DuBois RN.
Cyclooxygenase-1 is Overexpressed and Promotes Angiogenic Growth Factor Production in Ovarian Cancer.
Cancer Res. 2003 Mar 1;63(5):906-911.


Ma WG, Song H, Das SK, Paria BC, Dey SK.
Estrogen is a critical determinant that specifies the duration of the window of uterine receptivity for implantation.
Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2963-8.


Brisken C, Ayyannan A, Nguyen C, Heineman A, Reinhardt F, Tan J, Dey SK, Dotto GP, Weinberg RA.
IGF-2 Is a Mediator of Prolactin-Induced Morphogenesis in the Breast.
Dev Cell. 2003 Feb;4(2):283.


Paria BC, Wang H, Dey SK.
Endocannabinoid signaling in synchronizing embryo development and uterine receptivity for implantation.
Chem Phys Lipids. 2002 Dec;121(1-2):201-10.


Daikoku T, Matsumoto H, Gupta RA, Das SK, Gassmann M, DuBois RN, Dey SK.
Expression of hypoxia-inducible factors in the peri-implantation mouse uterus is regulated in a cell-specific and ovarian steroid hormone-dependent manner. Evidence for differential function of HIFs during early pregnancy.
J Biol Chem. 2003 Feb 28;278(9):7683-91.


Brisken C, Ayyannan A, Nguyen C, Heineman A, Reinhardt F, Tan J, Dey SK, Dotto GP, Weinberg RA, Jan T.
IGF-2 is a mediator of prolactin-induced morphogenesis in the breast.
Dev Cell. 2002 Dec;3(6):877-87.


Leach RE, Romero R, Kim YM, Chaiworapongsa T, Kilburn B, Das SK, Dey SK, Johnson A, Qureshi F, Jacques S, Armant DR.
Pre-eclampsia and expression of heparin-binding EGF-like growth factor.
Lancet. 2002 Oct 19;360(9341):1215-9.


Hough LB, Nalwalk JW, Stadel R, Timmerman H, Leurs R, Paria BC, Wang X, Dey SK.
Inhibition of improgan antinociception by the cannabinoid (CB)(1) antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A): lack of obligatory role for endocannabinoids acting at CB(1) receptors.
J Pharmacol Exp Ther. 2002 Oct;303(1):314-22.


Lim H, Dey SK.
A novel pathway of prostacyclin signaling-hanging out with nuclear receptors.
Endocrinology. 2002 Sep;143(9):3207-10. 12:


Paria BC, Reese J, Das SK, Dey SK.
Deciphering the cross-talk of implantation: advances and challenges.
Science. 2002 Jun 21;296(5576):2185-8.


Song H, Lim H, Paria BC, Matsumoto H, Swift LL, Morrow J, Bonventre JV, Dey SK.
Cytosolic phospholipase A2alpha is crucial [correction of A2alpha deficiency is crucial] for 'on-time' embryo implantation that directs subsequent development.
Development. 2002 Jun;129(12):2879-89.


Matsumoto H, Ma WG, Daikoku T, Zhao X, Paria BC, Das SK, Trzaskos JM, Dey SK.
Cyclooxygenase-2 differentially directs uterine angiogenesis during implantation in mice.
J Biol Chem. 2002 Aug 9;277(32):29260-7. 15:


Matsumoto H, Zhao X, Das SK, Hogan BL, Dey SK.
Indian hedgehog as a progesterone-responsive factor mediating epithelial-mesenchymal interactions in the mouse uterus.
Dev Biol. 2002 May 15;245(2):280-90.

Tan J, Raja S, Davis MK, Tawfik O, Dey SK, Das SK.
Evidence for coordinated interaction of cyclin D3 with p21 and cdk6 in directing the development of uterine stromal cell decidualization and polyploidy during implantation.
Mech Dev. 2002 Feb;111(1-2):99-113.

Vanderbilt University is committed to principles of equal opportunity and affirmative action.
Copyright © 2003, Vanderbilt Medical Center, 21st Avenue South and Garland Avenue
Last modified: May 7, 2004

"Links contained on this page to information provided by other organizations are presented as a service and neither constitutes nor implies Vanderbilt University Medical Center endorsement or warranty."