Center for Bone Biology

Jeffry S. Nyman, Ph.D.

University of California, Davis, 2003

Assistant Professor
Orthopaedic Surgery & Rehabilitation
Biomedical Engineering
 

Phone:  (615) 936-6296
Fax:  (615) 343-2611
Email:  jeffry.s.nyman@vanderbilt.edu  
 

Research Interests:
 

• Age- and diabetes-related effects on the mechanical behavior of bone
• Regulation of bone quality
• Effects of bone metastasis on tissue properties
• Whole bone- and tissue-level properties in rodent models of disease
• Role of bound water in the fracture resistance of bone
• Raman signatures of bone's resistance to fracture
   

Research Techniques: 
 

• Mechanical testing of bone
  • Monotonic: tension, compression, flexure, torsion
  • Fatigue: flexure, compression
  • Reference point indentation
• Metalluragic preparation of bone samples
• Histology

• Collagen crosslink analysis by HPLC
• Finite Element Method
• Histomorphometry
• Micro-computed tomography
• Raman micro-spectroscopy
• Nanoindentation
• ¹H NMR Relaxometry 
  
   

Professional Membership:
 

•  Orthopaedic Research Society
•  American Society for Bone and Mineral Research
•  International Bone and Mineral Society
  
   

Current Research Support:

Project Title:  Aging and Diabetes-Related Factors Compromising Bone Fracture Resistance
Funding Agency:  VA Merit Award
Project Title:  Dynamic Mechanical Behavior of Bone Tissue as Characterized by Nanoindentation
Funding Agency:  NSF7074068
Project Title:  Bone Pseudoarthrosis Dissected Through the Generation of New Mouse Models (Co-Investigator)
Funding Agency:  NIH/NIAMS 1R01 AR055966-01A1 (Elefteriou)
Project Title:  Roles of Collagen and Water in the Fracture Resistance of Bone
Funding Agency:  NIH/NIAMS 1R01 AR063157-01
 

Selected Publications: (Click PubMed link to view abstracts):
 

1. Makowski, A.J., Patil, C.A., Mahadevan-Jansen, A., and J.S. Nyman. Polarization Control of Raman Spectroscopy Optimizes the Assessment of Bone Tissue. Journal of Biomedical Optics. Accepted April 2013.
2. Anderson, C.N., Nyman, J.S.,
McCullough, K.A., Song, Y., Uppuganti, S.,  O’Neill, K.R., Anderson, A.F., and W.R. Dunn. Biomechanical evaluation of physeal sparing fixation methods in tibial eminence fractures. The American Journal of Sports Medicine. Accepted February 2013.

3. Starnes^, J.W., Neidre, D.B., Nyman, J.S., Roy, A., Nelson, M.J., Gutierrez, G. and X. Wang. Synergistic effect of exercise and statins on femoral strength in rats. Experimental Gerontology. Epub ahead of print.
4. Nyman, J.S., Gorochow, L. E., Horch, R.A., Uppuganti, S., Zein-Sabatto, A., Manhard, M.K. and M.D. Does. Partial removal of pore and loosely bound water by low-energy drying decreases cortical bone toughness in young and old donors. Journal of the Mechanical Behavior of Biomedical Materials. Epub ahead of print.
5. Edwards, J.R., Perrien, D.S., Fleming, N. Nyman, J.S., Ono, K., Connelly, L., Moore, M.M., Lwin, S.T., Yull, F.E., Mundy, G.R., and F. Elefteriou. Silent information regulator (Sir)T1 inhibits NFκB signaling to maintain normal skeletal remodeling. Journal of Bone and Mineral Research. 28:960-9, 2013.
6. Cole, H.A., Yuasa, M., Hawley G., Cates, J.M.M., Nyman, J.S., and J.G. Schoenecker. Differential development of the distal and proximal femoral epiphysis and physis in mice. Bone. 52:337-46, 2013.
7. Nyman, J.S.. Effect of diabetes on the fracture resistance of bone. Clinical Reviews in Bone and Mineral Metabolism. 11:38-48, 2013. Online at springerlink.com.
8. Lian, N., Lin, T., Liu, W., Wang, W., Li, L., Sun, S., Nyman, J.S., and X. Yang. Transforming Growth Factor b suppresses osteoblast differentiation via vimentin activating transcription factor 4 (ATF4) axis. The Journal of Biological Chemistry. 287:35975-84, 2012.
9. O’Neill, K.R., Stutz, C.M., Mignemi, N.A., Burns, M.C., Murry, M.R. Nyman, J.S., and J.G. Schoenecker. Micro-computed tomography assessment of the progression of fracture healing in mice bone. Bone. 50:1357-67, 2012.
10. O’Neill, K.R., Stutz, C.M., Mignemi, N.A., Cole, H., Murry, M.R. Nyman, J.S., Hamm, H. and J.G. Schoenecker. Fracture healing in protease-activated receptor-2 deficient mice.  Journal of Orthopaedics Research. 30:1271-6, 2012.
11. Nyman, J.S. and A.J. Makowski. The Contribution of the Extracellular Matrix to the Fracture Resistance of Bone. Current Osteoporosis Reports. 10:169-77, 2012.
12. Horch, R.A., Gochberg, D.F., Nyman, J.S., and M.D. Does. Clinically-compatible MRI strategies for discriminating bound and pore water in cortical bone. Magnetic Resonance in Medicine. 68:1774-84, 2012.
13. Biswas, S. Nyman, J.S., Alvarez, J., Chakrabarti, A., Ayers, A. Sterling, J. Edwards, J., Rana, T., Johnson, R., Perrien, D.S., Lonning, S. Shyr, Y., Matrisian, L.M., and G.R. Mundy. Anti-transforming growth factor β antibody treatment rescues bone loss and prevents breast cancer metastasis to bone. PLoS One. 6:e27090, 2011.
14. Wang, W., Nyman, J.S., Ono, K., Stevenson, D.A., Yang, X., and F. Elefteriou.  Mice lacking Nf1 in osteochondroprogenitor cells display skeletal dysplasia similar to patients with neurofibromatosis type I. Human Molecular Genetics. 20:3920-24, 2011.
15. Nyman, J.S., Makowski, A.J., Patil, C.A., Masui, T.P., O’Quinn, E.C., Bi, X., Guelcher, S.A., Nicollela, D.P. and A. Mahadevan-Jansen.  Measuring differences in compositional properties of bone tissue by confocal Raman Spectroscopy. Calcified Tissue International. 89:111-22, 2011.
16. Ma, Y., Nyman, J.S., Tao, H., Moss, H.H., Yang, X., and F. Elefteriou. β2-adrenergic receptor signaling in osteoblasts contributes to the catabolic effect of glucocorticoids on bone. Endocrinology. 152:1412-22, 2011.
17. Nyman, J.S., Even, J.L., Jo, C-H, Herbert, E.G., Murry, M.R., Cockrell, G.E., Wahl, E.C., Bunn, R.C., Lumpkin, Jr., C.K., Fowlkes, J.L., and K.M. Thrailkill. Increasing duration of type 1 diabetes perturbs the strength-structure relationship and increases brittleness of bone. Bone. 48:733-40, 2011.
18. Horch, R.A., Gochberg, D.F., Nyman, J.S., and M.D. Does. Non-invasive predictors of human cortical bone mechanical properties: T₂-discriminated ¹H NMR compared with high resolution X-ray. PLoS ONE. 6:e16359, 2011.
19. Nyman, J.S., Lynch, C.C., Perrien, D.S., Thiolloy, S., O'Quinn, E.C., Patil, C.A., Bi, X., Pharr, G.M., Mahadevan-Jansen, A., and G.R. Mundy. Differential effects between the loss of MMP-2 and MMP-9 on structural and tissue-level properties of bone.  Journal of Bone and Mineral Research. 26: 1252-60, 2011.
20. Bi, X., Patil, C.A., Lynch, C.C., Pharr, G.M., Mahadevan-Jansen, A., and J.S. Nyman. Raman and mechanical properties correlate at whole bone- and tissue-levels in a genetic mouse model. Journal of Biomechanics. 44: 297-303, 2011.
21. Patil, C. A., Kalkman, J., Faber, D. J., Nyman, J.S., Van Leeuwen, T.G., and A. Mahadevan-Jansen. Integrated system for combined Raman spectroscopy-spectral domain optical coherence tomography. Journal of Biomedical Optics. 16:011007, 2011.
22. Edwards, J.R., Nyman, J.S., Lwin, S.T., Moore, M.M, Esparza, J., O’Quinn, E.C.; Hart, A.J., Biswas, S.; Patil, C.; Lonning, S.; Mahadevan-Jansen, A., and G.R. Mundy.  Inhibition of TGF-β signaling by 1D11 antibody treatment increases bone mass and quality in vivo.  Journal of Bone and Mineral Research.  25:2419-26, 2010.
23. Horch, R.A. Nyman, J.S., Gochberg, D.F., Dortch, R.D., and M.D. Does.  Characterization of ¹H NMR Signal in Human Cortical Bone for Magnetic Resonance Imaging.  Magnetic Resonance in Medicine.  64:680-7, 2010.
24. Yoshii, T., Hafeman, A.E., Nyman, J.S., Esparza, J.M., Shinomiya, K. Spengler, D.M., Mundy, G.R., Gutierrez, G.E., and S.A. Guelcher.  A sustained release of lovastatin from biodegradable, elastomeric polyurethane scaffolds for enhanced bone regeneration.  Tissue Engineering Part A.  16:2369-79, 2010.
25. Wang, W., Nyman, J.S., Moss, H, Gutierrez, G.E., Mundy, G.R., Yang, X., and F. Elefteriou.  Local low dose lovastatin delivery improves the bone healing defect caused by Nf1 loss-of-function in osteoblasts.  Journal of Bone and Mineral Research. 25:1658-67, 2010.
26. Dumas, J.E., Davis, T., Holt, G.E., Yoshii, T., Perrien, D.S., Nyman, J.S., Boyce, T., and S.A. Guelcher.  Synthesis, characterization, and remodeling of weight-bearing allograft bone/polyurethane composites in the rabbit.  Acta Biomateriala.  6:2394-406, 2010.