After completion of a fracture experiment, we first quantify callus maturity with micro-computed tomography and then callus strength with biomechanical testing. We seek insight into how the drug therapy or genetic manipulation is affecting the biomechanical properties of bone.
|Here are three orthogonal images of rat fracture callus along with 3D rendering. Typically, the region of interest (ROI) is 3.2 mm above and below the fracture line.|| |
Three point bending generates a force-displacement curve from which we determine biomechanical properties as maximum force (structural strength).