Center for Bone Biology

Daniel S. Perrien, Ph.D.

University of Arkansas for Medical Sciences, 2006

Clinical Pharmacology

Phone:  (615) 343-2817

Fax:  (615) 343-2611

Email:  daniel.s.perrien@vanderbilt.edu

Research Interests

Skeletal response to mechanical loading and disuse
Anabolic agents for skeletal repair and regeneration
Role of angiogenesis in bone repair and remodeling
Musculoskeletal imaging
Mathematical models of skeletal strength and failure

Research Techniques

Computed Tomography and micro-Computed Tomography
Finite element modeling
Rodent models of fracture repair and distraction osteogenesis
Biomechanical testing
Histomorphometry
Immunohistochemistry
in situ hybridization
Bone cell culture

Dr. Perrien joined the VCBB in November 2008.  After receiving his Doctorate in Physiology and Biophysics from the University of Arkansas for Medical Sciences, he worked for an orthopaedic tissue engineering company, developing growth factor based drug/device therapies to enhance musculoskeletal repair.  Fracture repair and distraction osteogenesis continue to be major areas of investigation.  In addition, his efforts include mathematical modeling of structure-function relationships in bone, understanding the skeletal response to mechanical load, and endocrine control of bone mass and turnover.

Recent Publications
 

1. Perrien DS, Nicks KM, Liu L, Akel NS, Bacon AW, Skinner RA, Swain FL, Aronson J, Suva LJ, Gaddy D.  Inhibin A enhances bone formation during distraction osteogenesis.  J Orthop Res.  2011 Aug 1.  (Epub ahead of print)
2. Nyman JS, Lynch CC, Perrien DS, Thiolloy S, O'Quinn EC, Patil CA, Bi X, Pharr GM, Mahadevan-Jansen A, Mundy GR.  Differential effects between the lost of MMP-2 and MMP-9 on structural and tissue-level properties of bone.  J Bone Miner Res.  2011 June;26(6):1252-60.
3. Brown KV, Li B, Guda T, Perrien DS, Guelcher SA, Wenke JC.  Improving bone formation in a rat femur segmental defect by controlling bone morphogenetic protein-2 release.  Tissue Eng Part A.  2011 Jul;17(13-14):1735-46.
4. Sparks EE, Perrien DS, Huppert KA, Peterson TE, Huppert SS.  Defects in hepatic Notch signaling result in disruption of the communicating intrahepatic bile duct network in mice.  Dis Model Mech.  2011 May;4(3):359-67.
5. Nyman JS, Lynch CC, Perrien DS, Thiolloy S, O'Quinn EC, Patil CA, Bi X, Pharr GM, Mahadevan-Jansen A, Mundy GR.  Differential effects between the loss of MMP-2 and MMP-9 on structural and tissue-level properties of bone.  J Bone Miner Res.  2010 Dec 29.  (Epub ahead of print)
6. Nicks KM, Fowler TW, Akel NS, Perrien DS, Suva LJ, Gaddy D.  Bone turnover across the menopause transition:  The role of gonadal inhibins.  Ann N Y Acad Sci.  2010 Mar;1192:153-60.
7. Dumas JE, Davis T, Holt GE, Yoshii T, Perrien DS, Nyman JS, Boyce T, Guelcher SA.  Synthesis, characterization, and remodeling of weight-bearing allograft bone/polyurethane composites in the rabbit.  Acta Biomater.  2010 Jul;6(7):2394-406.
8. Wang W, Lian N, Li L, Moss HE, Wang W, Perrien DS, Elefteriou F, Yang X.  Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription.  Development.  2009 Dec;136(24):4143-53.
9. Nicks KM, Perrien DS, Akel NS, Suva LJ, Gaddy D.  Regulation of osteoblastogenesis and osteoclastogenesis by the other reproductive hormones, Activin and Inhibin.  Mol Cell Endocrinol.  2009 Oct 30;310(1-2):11-20. 
10. Fowlkes JL, Bunn RC, Liu L, Wahl EC, Coleman HN, Cockrell GE, Perrien DS, Lumpkin CK Jr, Thrailkill KM. Runt-related transcription factor 2 (RUNX2) and RUNX2-related osteogenic genes are down-regulated throughout osteogenesis in type 1 diabetes mellitus. Endocrinology. 2008 Apr;149(4):1697-704.
11. Shankar K, Hidestrand M, Liu X, Chen JR, Haley R, Perrien DS, Skinner RA, Lumpkin CK Jr, Badger TM, Ronis MJ. Chronic ethanol consumption inhibits postlactational anabolic bone rebuilding in female rats. J Bone Miner Res. 2008 Mar;23(3):338-49.