email@example.com Molecular Physiology & Biophysics Vanderbilt University Nashville TN 37232-0615
LAB: RRB Room 724 Phone: 615-936-1630
Research Interests & Current Projects
Calcium signaling is highly dynamic. Carefully orchestrated changes in the activities of numerous channels, pumps and exchangers typical result in pulsatile changes in cytosolic Ca2+ concentrations. Intracellular signaling pathways integrate information conveyed by the duration and amplitude of each "pulse" of Ca2+, as well as by the frequency of repeated pulses to elicit specific physiological responses. Many Ca2+ responses are mediated by calmodulin, a ubiquitous "Ca2+ sensor" protein that binds to and regulates many proteins in a Ca2+-dependent manner. One major target of Ca2+/calmodulin is Ca2+/calmodulin-dependent protein kinase II (CaMKII) which is the major research focus in the Colbran lab. The goal of our studies is to understand mechanisms that control the dynamic interplay between changes in Ca2+ concentrations and autophosphorylation/dephosphorylation of CaMKII in defined subcellular compartments and their relationship to physiological and pathological situations. Our major focus is on signaling in the dendritic spines at excitatory synapses, which are the subcellular compartments in neurons that control synaptic transmission, learning and memory in many brain regions.
Co-localization of CaMKII and neurabin (a PP1 targeting subunit) in neuronal dendritic spines.
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