2012
JS Orr, MJ Puglisi, K Ellacott, CN Lumeng, DH Wasserman, AH Hasty. TLR4 Deficiency Promotes the Alternative Activation of Adipose Tissue Macrophages. 2012. Diabetes. Accepted.
EK Anderson, AA Hill, AH Hasty. Stearic acid accumulation in macrophages induces TLR4-independent induction of inflammation, leading to ER stress-mediated apoptosis. 2012. Accepted. Arterioscler. Throm. & Vasc. Biol. Accepted.
A Kennedy, ML Gruen, DA Gutierrez, BK Surmi, CD Webb, and AH Hasty. Impact of Macrophage Inflammatory Protein-1α Deficiency on Atherosclerotic Lesion Formation, Hepatic Steatosis, and Adipose Tissue Expansion. 2012. PLoS ONE. 7:e31508.
DA Gutierrez and AH Hasty. Hematopoietic Leptin Receptor Deficiency Does Not Affect Macrophage Recruitment to Adipose Tissue. 2012. J. of Endo. 212:343-351.
DA Gutierrez, A Kennedy, JS Orr, EK Anderson, CD Webb, WK Gerrald, and AH Hasty. Aberrant accumulation of undifferentiated myeloid cells in the adipose tissue of CCR2 deficient mice delays improvements in insulin sensitivity. 2011. Diabetes. 60:2820-2829. www.ncbi.nlm.nih.gov/pubmed/21926275
Puglisi MJ, Hasty AH, Saraswathi V. The role of adipose tissue in mediating the benficial effects of dietary fish oil. J Nutr Biochem. 2011 Feb;22(2):101-8. www.ncbi.nlm.nih.gov/pubmed/21145721
2010
BK Surmi, CD Webb, AC Ristau, and AH Hasty. "Absence of macrophage inflammatory protein-1alpha does not impact macrophage accumulation in adipose tissue of diet induced obese mice". Am. J. Physiol Endocronol Metab. 2010. 299:E437-445. http://www.ncbi.nlm.nih.gov/pubmed/20551286
EK Anderson, DA Gutierrez and AH Hasty. "Adipose tissue recruitment of leukocytes". Current Opinion in Lipidology. 2010. 21:172-177. http://www.ncbi.nlm.nih.gov/pubmed/20410821
AJ Kennedy, KL Ellacott, VL King, and AH Hasty. "Mouse models of the metabolic syndrome". Disease Models and Mechanisms. 2010. 3:156-166. http://www.ncbi.nlm.nih.gov/pubmed/20212084
BK Surmi and AH Hasty. "The role of chemokines in recruitment of immune cells to the artery wall and adipose tissue". Vascular Pharmacology. 2010. 52:27-36. ww.ncbi.nlm.nih.gov/pubmed/20026286
2009
V Saraswathi and AH Hasty. Inhibition of long-chain acyl coenzyme A synthetases during fatty acid loading induces lipotixicity in macrophages. Arterioscler. Throm. Vasc. Biol. 2009. 29:1937-1943. www.ncbi.nlm.nih.gov/pubmed/19679826
V Saraswathi, JD Morrow, and AH Hasty. Dietary fish oil exerts hypolipidemic effects in lean and insulin sensitizing effects in obese LDLR-/- mice. 2009. J. Nutr. 139:2380-2386. www.ncbi.nlm.nih.gov/pubmed/19864403
DA Gutierrez, MJ Puglisi, AH Hasty. “The link between adipose tissue, inflammation, dyslipidemia and cardiovascular disease in diabetes”. Invited Review for Disorders of Lipid Metabolism section of Current Diabetes Reports. 2009. 9:26-32. www.ncbi.nlm.nih.gov/pubmed/19192421
KR Coenen, ML Gruen, RS Lee-Young, MJ Puglisi, DH Wasserman, AH Hasty*. Impact of macrophage Toll-like receptor 4 deficiency on macrophage infiltration into adipose tissue and the artery wall in mice. 2009. Diabetologia. 52:318-328. www.ncbi.nlm.nih.gov/pubmed/19052722
2008
BK Surmi and AH Hasty*. “Macrophage infiltration into adipose tissue: Initiation, propagation, and remodeling”. 2008. Future Lipidology. 3:545-556. www.futuremedicine.com/doi/abs/10.2217/17460875.3.5.545
Atkinson, RD, Coenen, KR, Plummer, MR, Gruen, ML, Hasty, AH. Macrophage-derived apolipoprotein E ameliorates dyslipidemia and atherosclerosis in obese apolipoprotein E-deficient mice. Am J Physiol Endocrinol Metab, 294(2), E284-90, 2008. www.ncbi.nlm.nih.gov/pubmed/18029445
MR Plummer and AH Hasty*. Atherosclerotic lesion formation and triglyceride storage in obese apolipoprotein AI deficient mice. 2008. J. Nut. Biochem. 19:664-673. www.ncbi.nlm.nih.gov/pubmed/18280133
Surmi, BK, Atkinson, RD, Gruen, ML, Coenen, KR, Hasty, AH. The role of macrophage leptin receptor in aortic root lesion formation. Am J Physiol Endocrinol Metab, 294(3), E488-95, 2008. www.ncbi.nlm.nih.gov/pubmed/18182468
2007
Coenen, KR, Gruen, ML, Chait, A, Hasty, AH. Diet-induced increases in adiposity, but not plasma lipids, promote macrophage infiltration into white adipose tissue. Diabetes, 56(3), 564-73, 2007
Coenen, KR, Gruen, ML, Hasty, AH. Obesity causes very low density lipoprotein clearance defects in low-density lipoprotein receptor-deficient mice. J Nutr Biochem, 18(11), 727-35, 2007
Coenen, KR, Hasty, AH. Obesity potentiates development of fatty liver and insulin resistance, but not atherosclerosis, in high-fat diet-fed agouti LDLR-deficient mice. Am J Physiol Endocrinol Metab, 293(2), E492-9, 2007
Gruen, ML, Hao, M, Piston, DW, Hasty, AH. Leptin requires canonical migratory signaling pathways for induction of monocyte and macrophage chemotaxis. Am J Physiol Cell Physiol, 293(5), C1481-8, 2007
Nuotio-Antar, AM, Hachey, DL, Hasty, AH. Carbenoxolone treatment attenuates symptoms of metabolic syndrome and atherogenesis in obese, hyperlipidemic mice. Am J Physiol Endocrinol Metab, 293(6), E1517-28, 2007
Saraswathi, V, Gao, L, Morrow, JD, Chait, A, Niswender, KD, Hasty, AH. Fish Oil Increases Cholesterol Storage in White Adipose Tissue with Concomitant Decreases in Inflammation, Hepatic Steatosis, and Atherosclerosis in Mice. J Nutr, 137(7), 1776-1782, 2007
2006
Gruen, ML, Saraswathi, V, Nuotio-Antar, AM, Plummer, MR, Coenen, KR, Hasty, AH. Plasma insulin levels predict atherosclerotic lesion burden in obese hyperlipidemic mice. Atherosclerosis, 186(1), 54-64, 2006
Hasty, AH, Gruen, ML, Terry, ES, Surmi, BK, Atkinson, RD, Gao, L, Morrow, JD. Effects of vitamin E on oxidative stress and atherosclerosis in an obese hyperlipidemic mouse model. J Nutr Biochem, , , 2006
Nuotio-Antar, AM, Hasty, AH, Kovacs, WJ. Quantitation and cellular localization of 11beta-HSD1 expression in murine thymus. J Steroid Biochem Mol Biol, 99(2-3), 93-9, 2006
Saraswathi, V, Hasty, AH. The role of lipolysis in mediating the pro-inflammatory effects of very low density lipoproteins in mouse peritoneal macrophages. J Lipid Res, , , 2006
2005
Gruen, ML, Plummer, MR, Zhang, W, Posey, KA, Linton, MF, Fazio, S, Hasty, AH. Persistence of high density lipoprotein particles in obese mice lacking apolipoprotein A-I. J Lipid Res, 46(9), 2007-14, 2005
Hasty, AH, Plummer, MR, Weisgraber, KH, Linton, MF, Fazio, S, Swift, LL. The recycling of apolipoprotein E in macrophages: influence of HDL and apolipoprotein A-I. J Lipid Res, 46(7), 1433-9, 2005
Collaborations with other Vanderbilt Laboratories
Stafford, JM, Yu, F, Printz, R, Hasty, AH, Swift, LL, Niswender, KD. Central nervous system neuropeptide Y signaling modulates VLDL triglyceride secretion. Diabetes, 57(6), 1482-90, 2008
Wang, Y, Oeser, JK, Yang, C, Sarkar, S, Hackl, SI, Hasty, AH, McGuinness, OP, Paradee, W, Hutton, JC, Powell, DR, O''Brien, RM. Deletion of the gene encoding the ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein (UGRP)/glucose-6-phosphatase catalytic subunit-beta results in lowered plasma cholesterol and elevated glucagon. J Biol Chem, 281(52), 39982-9, 2006
Liang, X, Kanjanabuch, T, Mao, SL, Hao, CM, Tang, YW, Declerck, PJ, Hasty, AH, Wasserman, DH, Fogo, AB, Ma, LJ. Plasminogen activator inhibitor-1 modulates adipocyte differentiation. Am J Physiol Endocrinol Metab, 290(1), E103-E113, 2006
Zhu, MY, Hasty, AH, Harris, C, Linton, MF, Fazio, S, Swift, LL. Physiological relevance of apolipoprotein E recycling: studies in primary mouse hepatocytes. Metabolism, 54(10), 1309-15, 2005
Ru Su, Yan, Ishiguro, Hiroyuki, Major, Amy S, Dove, Dwayne E, Zhang, Wenwu, Hasty, Alyssa H, Babaev, Vladimir R, Linton, MacRae F, Fazio, Sergio. Macrophage apolipoprotein A-I expression protects against atherosclerosis in ApoE-Deficient mice and up-regulates ABC transporters.. Mol Ther, 8(4), 576-83, 2003
Braun, NA, Mohler, PJ, Weisgraber, KH, Hasty, AH, Linton, MF, Yancey, PG, Su, YR, Fazio, S, Swift, LL. Intracellular trafficking of recycling apolipoprotein E in Chinese hamster ovary cells. J Lipid Res, 47(6), 1176-86, 2006
Hao, M, Head, WS, Gunawardana, SC, Hasty, AH, Piston, DW. Direct effect of cholesterol on insulin secretion: a novel mechanism for pancreatic beta-cell dysfunction. Diabetes, 56(9), 2328-38, 2007
Su, YR, Dove, DE, Major, AS, Hasty, AH, Boone, B, Linton, MF, Fazio, S. Reduced ABCA1-mediated cholesterol efflux and accelerated atherosclerosis in apolipoprotein E-deficient mice lacking macrophage-derived ACAT1. Circulation, 111(18), 2373-81, 2005
Farkas, Monica H, Swift, Larry L, Hasty, Alyssa H, Linton, MacRae F, Fazio, Sergio. The recycling of apolipoprotein E in primary cultures of mouse hepatocytes. Evidence for a physiologic connection to high density lipoprotein metabolism.. J Biol Chem, 278(11), 9412-7, 2003
