Lab Info
Our long-term goal is to determine how adipose tissue contributes to the development of inflammation, dyslipidemia, and insulin resistance ultimately leading to type 2 diabetes and cardiovascular disease.
We use mouse models such as:
- leptin deficient (ob/ob)
- leptin receptor deficient (db/db)
- Toll-like receptor 4 deficient
- MIP-1a deficient,
- MCP-1 deficient
- Agouti
- low density lipoprotein receptor deficient
We use techniques such as:
- in vivo physiological measurements
- plasma lipid measurements
- in vitro tissue culture work
- RNA isolation and RT-PCR
- protein isolation and Western blotting
- immunohistochemical analyses
- atherosclerotic lesion quantification
- bone marrow transplants
- fat transplants