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Lab Info

Our long-term goal is to determine how adipose tissue contributes to the development of inflammation, dyslipidemia, and insulin resistance ultimately leading to type 2 diabetes and cardiovascular disease.

We use mouse models such as:

  • leptin deficient (ob/ob)
  • leptin receptor deficient (db/db)
  • Toll-like receptor 4 deficient
  • MIP-1a deficient,
  • MCP-1 deficient
  • Agouti
  • low density lipoprotein receptor deficient

We use techniques such as:  

  • in vivo physiological measurements
  • plasma lipid measurements
  • in vitro tissue culture work
  • RNA isolation and RT-PCR
  • protein isolation and Western blotting
  • immunohistochemical analyses
  • atherosclerotic lesion quantification
  • bone marrow transplants
  • fat transplants


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This page was last updated September 6, 2008 and is maintained by Hasty Lab