Molecular Physiology & Biophysics

Bariatric surgery is the only effective treatment for severe obesity and Type 2 Diabetes. Research on the mechanism of action of bariatric procedures has been performed in model systems to support the hypothesis that the beneficial effects result from more than the restrictive or malabsorptive effects of the procedures. Indeed, data argue that changes in gut-brain signaling in the Roux-en-Y bypass and sleeve gastrectomy procedures alter satiety, hunger, food preferences, and glucose homeostasis prior to the achievement of significant weight loss. Understanding the cellular and molecular bases of these changes might lead to the development of pharmaceutical interventions, or optimized surgical procedures for the treatment of obesity and diabetes. The mouse provides the best model for cellular and molecular studies because transgenesis can be used to alter individual genes, and to label specific cell types. The Vanderbilt Bariatric Surgery Shared Resource provides surgical services and tissues from mice to the scientific community.

List of available  tissues

Publications

Yin DP, Gao Q, Ma LL, Yan W, Williams PE, McGuinness OP, Wasserman DH, Abumrad NN. Assessment of different bariatric surgeries in the treatment of obesity and insulin resistance in mice. Ann Surg 2011 Jul;254(1):73-82

Hatoum, I.J., Stylopolous, N., Vanhoose, A.M., Boyd, K., Yin, D.P., Ellacott, K.L.J., Ma, L., Blaszczyk, K., Heogh, J.M., Cone, R.D., Farooqi, I.S., Kaplan, L.M. Melanocortin 4 Receptor Signaling is Required for Weight Loss after Gastric Bypass Surgery. J. Clin. End. Metab. (in press).

 
Erreger, K., Davis, A.R., Poe, A.M., Greig, N.H., Stanwood, G.D., Galli, A. Exendin-4 Decreases Amphetamine-induced Locomotor Activity. Physiology and Behavior (in press).
 
Nair S, Al-Hendy A, Tamboli RA, Marks-Shulman PA, Abumrad NN.  Letter to the Editor. Mol Cell Endocrinol. 2012 Feb 10. Epub ahead of print]. PMID:22342814

Tamboli RA, Hajri T, Jiang A, Marks-Shulman PA, Williams DB, Clements RH, Melvin W, Bowen BP, Shyr Y, Abumrad NN, Flynn CR. Reduction in inflammatory gene expression in skeletal muscle from Roux-en-Y gastric bypass patients randomized to omentectomy. PLoS One. 2011;6(12):e28577. Epub 2011 Dec 16. PMID:22194858

Dunn JP, Abumrad NN, Breitman I, Marks-Shulman PA, Flynn CR, Jabbour K, Feurer ID, Tamboli RA. Hepatic and peripheral insulin sensitivity and diabetes remission at 1 month after Roux-en-Y gastric bypass surgery in patients randomized to omentectomy. Diabetes Care. 2012 Jan;35(1):137-42. Epub 2011 Oct 31. PMID:22040841

JP Dunn, RM Kessler, ID Feurer, ND  Volkow, BW Patterson,  MS Ansari, R Li, P Marks-Shulman, NN Abumrad. Relationship of dopamine type 2 receptor binding potential with fasting neuroendocrine hormones and insulin sensitivity in human obesity. Diabetes Care. In Press, 2012
 
Erreger, K., Watt, E.E., Owens, W., Robertson, S.D., Saunders, S., Matthies, H.J.G., Rogers, K.A., Vaughan, R.A., West, A.R., Greig, N.H., Ayala,  J.E., Daws, L.C., Niswender, K.D., Galli, A. Glucagon-like peptide-1 (GLP-1) regulates striatal dopamine transporter function and trafficking through a novel transsynaptic mechanism, J. Neurosci. (submitted).