Moses Lab

Publications

Bierie B, Chung CH, Parker JS, Stover DG, Cheng N, Chytil A, Aakre M, Shyr Y, Moses HL. Abrogation of TGF-beta signaling enhances chemokine production and correlates with prognosis in human breast cancer. J Clin Invest, 119(6), 1571-82, 2009.
Abel TW, Clark C, Bierie B, Chytil A, Aakre M, Gorska A, Moses HL. GFAP-Cre-mediated activation of oncogenic K-ras results in expansion of the subventricular zone and infiltrating glioma. Mol Cancer Res, 7(5), 645-53, 2009.
Bierie B, Gorska AE, Stover DG, Moses HL. TGF-beta promotes cell death and suppresses lactation during the second stage of mammary involution. J Cell Physiol, 219(1), 57-68, 2009.
Yang L, Moses HL. Transforming growth factor beta: tumor suppressor or promoter? Are host immune cells the answer? Cancer Res, 68(22), 9107-11, 2008.
Cheng N, Chytil A, Shyr Y, Joly A, Moses HL. Transforming growth factor-beta signaling-deficient fibroblasts enhance hepatocyte growth factor signaling in mammary carcinoma cells to promote scattering and invasion. Mol Cancer Res, 6(10), 1521-33, 2008.
Brown KA, Ham AJ, Clark CN, Meller N, Law BK, Chytil A, Cheng N, Pietenpol JA, Moses HL. Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1. J Cell Biochem, 105(2), 596-611, 2008.
Erdogan M, Pozzi A, Bhowmick N, Moses HL, Zent R. Transforming growth factor-beta (TGF-beta) and TGF-beta-associated kinase 1 are required for R-Ras-mediated transformation of mammary epithelial cells. Cancer Res, 68(15), 6224-31, 2008.
Bierie B, Stover DG, Abel TW, Chytil A, Gorska AE, Aakre M, Forrester E, Yang L, Wagner KU, Moses HL. Transforming growth factor-beta regulates mammary carcinoma cell survival and interaction with the adjacent microenvironment. Cancer Res, 68(6), 1809-19, 2008.
Chen H, Zhuang F, Liu YH, Xu B, Del Moral P, Deng W, Chai Y, Kolb M, Gauldie J, Warburton D, Moses HL, Shi W. TGF-beta receptor II in epithelia versus mesenchyme plays distinct roles in the developing lung. Eur Respir J, 32(2), 285-95, 2008.
Yang, L, Huang, J, Ren, X, Gorska, AE, Chytil, A, Aakre, M, Carbone, DP, Matrisian, LM, Richmond, A, Lin, PC, Moses, HL Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. Cancer Cell, 13(1), 23-35, 2008.
Erdogan, M, Pozzi, A, Bhowmick, N, Moses, HL, Zent, R Transforming growth factor-beta (TGF-beta) and TGF-beta-associated kinase 1 are required for R-Ras-mediated transformation of mammary epithelial cells. Cancer Res, 68(15), 6224-31, 2008.
Bierie, B, Stover, DG, Abel, TW, Chytil, A, Gorska, AE, Aakre, M, Forrester, E, Yang, L, Wagner, KU, Moses, HL Transforming growth factor-beta regulates mammary carcinoma cell survival and interaction with the adjacent microenvironment. Cancer Res, 68(6), 1809-19, 2008.
Stover, DG, Bierie, B, Moses, HL A delicate balance: TGF-beta and the tumor microenvironment. J Cell Biochem, 2007.
Brown, KA, Pietenpol, JA, Moses, HL A tale of two proteins: Differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling. J Cell Biochem, 101(1), 9-33, 2007.
Cheng, N, Chytil, A, Shyr, Y, Joly, A, Moses, HL Enhanced Hepatocyte Growth Factor Signaling by Type II Transforming Growth Factor-{beta} Receptor Knockout Fibroblasts Promotes Mammary Tumorigenesis. Cancer Res, 2007.
Bonine-Summers, AR, Aakre, ME, Brown, KA, Arteaga, CL, Pietenpol, JA, Moses, HL, Cheng, N Epidermal Growth Factor Receptor Plays a Significant Role in Hepatocyte Growth Factor Mediated Biological Responses in Mammary Epithelial Cells. Cancer Biol Ther, 6(4), 2007.
Biswas, S, Guix, M, Rinehart, C, Dugger, TC, Chytil, A, Moses, HL, Freeman, ML, Arteaga, CL Inhibition of TGF-beta with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression. J Clin Invest, 117(5), 1305-13, 2007.
Ijichi, H, Chytil, A, Gorska, AE, Aakre, ME, Fujitani, Y, Fujitani, S, Wright, CV, Moses, HL Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression. Genes Dev, 20(22), 3147-60, 2006.
Longobardi, L, O''Rear, L, Aakula, S, Johnstone, B, Shimer, K, Chytil, A, Horton, WA, Moses, HL, Spagnoli, A Effect of IGF-I in the chondrogenesis of bone marrow mesenchymal stem cells in the presence or absence of TGF-beta signaling. J Bone Miner Res, 21(4), 626-36, 2006.
Halder, SK, Anumanthan, G, Maddula, R, Mann, J, Chytil, A, Gonzalez, AL, Washington, MK, Moses, HL, Beauchamp, RD, Datta, PK Oncogenic function of a novel WD-domain protein, STRAP, in human carcinogenesis. Cancer Res, 66(12), 6156-66, 2006.
Jiao, K, Langworthy, M, Batts, L, Brown, CB, Moses, HL, Baldwin, HS Tgfbeta signaling is required for atrioventricular cushion mesenchyme remodeling during in vivo cardiac development. Development, 133(22), 4585-93, 2006.
Mu??oz, NM, Upton, M, Rojas, A, Washington, MK, Lin, L, Chytil, A, Sozmen, EG, Madison, BB, Pozzi, A, Moon, RT, Moses, HL, Grady, WM Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. Cancer Res, 66(20), 9837-44, 2006.
Bierie, B, Moses, HL Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer. Nat Rev Cancer, 6(7), 506-20, 2006.
Desgrosellier, JS, Mundell, NA, McDonnell, MA, Moses, HL, Barnett, JV Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formation. Dev Biol, 280(1), 201-10, 2005.
Romero-Gallo, J, Sozmen, EG, Chytil, A, Russell, WE, Whitehead, R, Parks, WT, Holdren, MS, Her, MF, Gautam, S, Magnuson, M, Moses, HL, Grady, WM Inactivation of TGF-beta signaling in hepatocytes results in an increased proliferative response after partial hepatectomy. Oncogene, 24(18), 3028-41, 2005.
Means, AL, Chytil, A, Moses, HL, Coffey, RJ, Wright, CV, Taketo, MM, Grady, WM Keratin 19 gene drives Cre recombinase expression throughout the early postimplantation mouse embryo. Genesis, 42(1), 23-7, 2005.
Cheng, N, Bhowmick, NA, Chytil, A, Gorksa, AE, Brown, KA, Muraoka, R, Arteaga, CL, Neilson, EG, Hayward, SW, Moses, HL Loss of TGF-beta type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-alpha-, MSP- and HGF-mediated signaling networks. Oncogene, 24(32), 5053-68, 2005.
O''Rear, L, Longobardi, L, Torello, M, Law, BK, Moses, HL, Chiarelli, F, Spagnoli, A Signaling cross-talk between IGF-binding protein-3 and transforming growth factor-(beta) in mesenchymal chondroprogenitor cell growth. J Mol Endocrinol, 34(3), 723-37, 2005.
Bierie, B, Moses, HL TGF-beta and cancer. Cytokine Growth Factor Rev, 17(1-2), 29-40, 2005.
Bhowmick, NA, Moses, HL Tumor-stroma interactions. Curr Opin Genet Dev, 15(1), 97-101, 2005.
Bierie, B, Moses, HL Under pressure: stromal fibroblasts change their ways. Cell, 123(6), 985-7, 2005.
Xie, L, Law, BK, Chytil, AM, Brown, KA, Aakre, ME, Moses, HL Activation of the Erk pathway is required for TGF-beta1-induced EMT in vitro. Neoplasia, 6(5), 603-10, 2004.
Brown, KA, Aakre, ME, Gorska, AE, Price, JO, Eltom, SE, Pietenpol, JA, Moses, HL Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro. Breast Cancer Res, 6(3), R215-31, 2004.
Bhowmick, NA, Neilson, EG, Moses, HL Stromal fibroblasts in cancer initiation and progression. Nature, 432(7015), 332-7, 2004.
Bhowmick, Neil A, Chytil, Anna, Plieth, David, Gorska, Agnieszka E, Dumont, Nancy, Shappell, Scott, Washington, M Kay, Neilson, Eric G, Moses, Harold L TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science, 303(5659), 848-51, 2004.
Biswas, S, Chytil, A, Washington, K, Romero-Gallo, J, Gorska, AE, Wirth, PS, Gautam, S, Moses, HL, Grady, WM Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancer. Cancer Res, 64(14), 4687-92, 2004.
Muraoka, Rebecca S, Koh, Yasuhiro, Roebuck, L Renee, Sanders, Melinda E, Brantley-Sieders, Dana, Gorska, Agnieszka E, Moses, Harold L, Arteaga, Carlos L Increased malignancy of Neu-induced mammary tumors overexpressing active transforming growth factor beta1. Mol Cell Biol, 23(23), 8691-703, 2003.
Bhowmick, Neil A, Ghiassi, Mayshan, Aakre, Mary, Brown, Kimberly, Singh, Vikas, Moses, Harold L TGF-beta-induced RhoA and p160ROCK activation is involved in the inhibition of Cdc25A with resultant cell-cycle arrest. Proc Natl Acad Sci U S A, 100(26), 15548-53, 2003.
Tu, William H, Thomas, Tania Z, Masumori, Naoya, Bhowmick, Neil A, Gorska, Agnieszka E, Shyr, Yu, Kasper, Susan, Case, Tom, Roberts, Richard L, Shappell, Scott B, Moses, Harold L, Matusik, Robert J The loss of TGF-beta signaling promotes prostate cancer metastasis. Neoplasia, 5(3), 267-77, 2003.
Xie, Lu, Law, Brian K, Aakre, Mary E, Edgerton, Mary, Shyr, Yu, Bhowmick, Neil A, Moses, Harold L Transforming growth factor beta-regulated gene expression in a mouse mammary gland epithelial cell line. Breast Cancer Res, 5(6), R187-98, 2003.
Gorska, Agnieszka E, Jensen, Roy A, Shyr, Yu, Aakre, Mary E, Bhowmick, Neil A, Moses, Harold L Transgenic mice expressing a dominant-negative mutant type II transforming growth factor-beta receptor exhibit impaired mammary development and enhanced mammary tumor formation. Am J Pathol, 163(4), 1539-49, 2003.
Chytil, Anna, Magnuson, Mark A, Wright, Christopher V E, Moses, Harold L Conditional inactivation of the TGF-beta type II receptor using Cre:Lox. Genesis, 32(2), 73-5, 2002.
Law, Brian K, Chytil, Anna, Dumont, Nancy, Hamilton, Elizabeth G, Waltner-Law, Mary E, Aakre, Mary E, Covington, Cassondra, Moses, Harold L Rapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells. Mol Cell Biol, 22(23), 8184-98, 2002.
McDonnell, M A, Law, B K, Serra, R, Moses, H L Antagonistic effects of TGFbeta1 and BMP-6 on skin keratinocyte differentiation. Exp Cell Res, 263(2), 265-73, 2001.
Entingh, A J, Law, B K, Moses, H L Induction of the C/EBP homologous protein (CHOP) by amino acid deprivation requires insulin-like growth factor I, phosphatidylinositol 3-kinase, and mammalian target of rapamycin signaling. Endocrinology, 142(1), 221-8, 2001.
Bhowmick, N A, Zent, R, Ghiassi, M, McDonnell, M, Moses, H L Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity. J Biol Chem, 276(50), 46707-13, 2001.
Bragg, A D, Moses, H L, Serra, R Signaling to the epithelium is not sufficient to mediate all of the effects of transforming growth factor beta and bone morphogenetic protein 4 on murine embryonic lung development. Mech Dev, 109(1), 13-26, 2001.
Bhowmick, N A, Ghiassi, M, Bakin, A, Aakre, M, Lundquist, C A, Engel, M E, Arteaga, C L, Moses, H L Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. Mol Biol Cell, 12(1), 27-36, 2001.
Law, B K, Norgaard, P, Moses, H L Farnesyltransferase inhibitor induces rapid growth arrest and blocks p70s6k activation by multiple stimuli. J Biol Chem, 275(15), 10796-801, 2000.
Bakin, A V, Tomlinson, A K, Bhowmick, N A, Moses, H L, Arteaga, C L Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration. J Biol Chem, 275(47), 36803-10, 2000.
Datta, P K, Blake, M C, Moses, H L Regulation of plasminogen activator inhibitor-1 expression by transforming growth factor-beta -induced physical and functional interactions between smads and Sp1. J Biol Chem, 275(51), 40014-9, 2000.
Datta, P K, Moses, H L STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling. Mol Cell Biol, 20(9), 3157-67, 2000.
Law, B K, Waltner-Law, M E, Entingh, A J, Chytil, A, Aakre, M E, N??rgaard, P, Moses, H L Salicylate-induced growth arrest is associated with inhibition of p70s6k and down-regulation of c-myc, cyclin D1, cyclin A, and proliferating cell nuclear antigen. J Biol Chem, 275(49), 38261-7, 2000.
N??rgaard, P, Law, B K, Plovisson, H S, Moses, H L Farnesyltransferase inhibitor-induced regression of mammary tumors in TGF alpha and TGF alpha/neu transgenic mice correlates with inhibition of map kinase and p70s6 kinase phosphorylation. Ann N Y Acad Sci, 886265-8, 1999.
Law, B K, N??rgaard, P, Gnudi, L, Kahn, B B, Poulson, H S, Moses, H L Inhibition of DNA synthesis by a farnesyltransferase inhibitor involves inhibition of the p70(s6k) pathway. J Biol Chem, 274(8), 4743-8, 1999.
Engel, M E, McDonnell, M A, Law, B K, Moses, H L Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription. J Biol Chem, 274(52), 37413-20, 1999.
Joseph, H, Gorska, A E, Sohn, P, Moses, H L, Serra, R Overexpression of a kinase-deficient transforming growth factor-beta type II receptor in mouse mammary stroma results in increased epithelial branching. Mol Biol Cell, 10(4), 1221-34, 1999.
Saha, D, Datta, P K, Sheng, H, Morrow, J D, Wada, M, Moses, H L, Beauchamp, R D Synergistic induction of cyclooxygenase-2 by transforming growth factor-beta1 and epidermal growth factor inhibits apoptosis in epithelial cells. Neoplasia, 1(6), 508-17, 1999.
N??rgaard, P, Law, B, Joseph, H, Page, D L, Shyr, Y, Mays, D, Pietenpol, J A, Kohl, N E, Oliff, A, Coffey, R J, Poulsen, H S, Moses, H L Treatment with farnesyl-protein transferase inhibitor induces regression of mammary tumors in transforming growth factor (TGF) alpha and TGF alpha/neu transgenic mice by inhibition of mitogenic activity and induction of apoptosis. Clin Cancer Res, 5(1), 35-42, 1999.
Gorska, A E, Joseph, H, Derynck, R, Moses, H L, Serra, R Dominant-negative interference of the transforming growth factor beta type II receptor in mammary gland epithelium results in alveolar hyperplasia and differentiation in virgin mice. Cell Growth Differ, 9(3), 229-38, 1998.
Datta, P K, Chytil, A, Gorska, A E, Moses, H L Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling. J Biol Chem, 273(52), 34671-4, 1998.
Engel, M E, Datta, P K, Moses, H L RhoB is stabilized by transforming growth factor beta and antagonizes transcriptional activation. J Biol Chem, 273(16), 9921-6, 1998.
Engel, M E, Datta, P K, Moses, H L Signal transduction by transforming growth factor-beta: a cooperative paradigm with extensive negative regulation. J Cell Biochem Suppl, 30-31111-22, 1998.
Alexandrow, M G, Moses, H L c-myc-enhanced S phase entry in keratinocytes is associated with positive and negative effects on cyclin-dependent kinases. J Cell Biochem, 70(4), 528-42, 1998.
Serra, R, Johnson, M, Filvaroff, E H, LaBorde, J, Sheehan, D M, Derynck, R, Moses, H L Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis. J Cell Biol, 139(2), 541-52, 1997.
Alexandrow, M G, Moses, H L Kips off to Myc: implications for TGF beta signaling. J Cell Biochem, 66(4), 427-32, 1997.
Holt, J T, Arteaga, C B, Robertson, D, Moses, H L Gene therapy for the treatment of metastatic breast cancer by in vivo transduction with breast-targeted retroviral vector expressing antisense c-fos RNA. Hum Gene Ther, 7(11), 1367-80, 1996.
Moses, H L, Serra, R Regulation of differentiation by TGF-beta. Curr Opin Genet Dev, 6(5), 581-6, 1996.
Arteaga, C L, Moses, H L TGF-beta in mammary development and neoplasia. J Mammary Gland Biol Neoplasia, 1(4), 327-9, 1996.
Serra, R, Moses, H L Tumor suppressor genes in the TGF-beta signaling pathway. Nat Med, 2(4), 390-1, 1996.
Kawabata, M, Chytil, A, Moses, H L Cloning of a novel type II serine/threonine kinase receptor through interaction with the type I transforming growth factor-beta receptor. J Biol Chem, 270(10), 5625-30, 1995.
Dagnino, L, Zhu, L, Skorecki, K L, Moses, H L E2F-independent transcriptional repression by p107, a member of the retinoblastoma family of proteins. Cell Growth Differ, 6(2), 191-8, 1995.
Kawabata, M, Imamura, T, Miyazono, K, Engel, M E, Moses, H L Interaction of the transforming growth factor-beta type I receptor with farnesyl-protein transferase-alpha. J Biol Chem, 270(50), 29628-31, 1995.
Pierce, D F, Gorska, A E, Chytil, A, Meise, K S, Page, D L, Coffey, R J, Moses, H L Mammary tumor suppression by transforming growth factor beta 1 transgene expression. Proc Natl Acad Sci U S A, 92(10), 4254-8, 1995.
Alexandrow, M G, Kawabata, M, Aakre, M, Moses, H L Overexpression of the c-Myc oncoprotein blocks the growth-inhibitory response but is required for the mitogenic effects of transforming growth factor beta 1. Proc Natl Acad Sci U S A, 92(8), 3239-43, 1995.
Chen, R.-H., Moses, H.L., Maruoka, E.M., Derynck, R., and Kawabata, M "Phosphorylation-dependent interaction of the cytoplasmic domains of the type I and type II transforming growth factor-? receptors." J. Biol. Chem., 27012235-12241, 1995.
Alexandrow, M G, Moses, H L Transforming growth factor beta 1 inhibits mouse keratinocytes late in G1 independent of effects on gene transcription. Cancer Res, 55(17), 3928-32, 1995.
Alexandrow, M G, Moses, H L Transforming growth factor beta and cell cycle regulation. Cancer Res, 55(7), 1452-7, 1995.
Serra, R, Moses, H L pRb is necessary for inhibition of N-myc expression by TGF-beta 1 in embryonic lung organ cultures. Development, 121(9), 3057-66, 1995.
Satterwhite, D J, Aakre, M E, Gorska, A E, Moses, H L Inhibition of cell growth by TGF beta 1 is associated with inhibition of B-myb and cyclin A in both BALB/MK and Mv1Lu cells. Cell Growth Differ, 5(8), 789-99, 1994.
Satterwhite, D J, Moses, H L Mechanisms of transforming growth factor-beta 1-induced cell cycle arrest. Invasion Metastasis, 14(1-6), 309-18, 1994.
Serra, R, Pelton, R W, Moses, H L TGF beta 1 inhibits branching morphogenesis and N-myc expression in lung bud organ cultures. Development, 120(8), 2153-61, 1994.
Moses, H L, Arteaga, C L, Alexandrow, M G, Dagnino, L, Kawabata, M, Pierce, D F, Serra, R TGF beta regulation of cell proliferation. Princess Takamatsu Symp, 24250-63, 1994.
Pierce, D F, Johnson, M D, Matsui, Y, Robinson, S D, Gold, L I, Purchio, A F, Daniel, C W, Hogan, B L, Moses, H L Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-beta 1. Genes Dev, 7(12A), 2308-17, 1993.
Levine, J H, Moses, H L, Gold, L I, Nanney, L B Spatial and temporal patterns of immunoreactive transforming growth factor beta 1, beta 2, and beta 3 during excisional wound repair. Am J Pathol, 143(2), 368-80, 1993.
Arteaga, C L, Carty-Dugger, T, Moses, H L, Hurd, S D, Pietenpol, J A Transforming growth factor beta 1 can induce estrogen-independent tumorigenicity of human breast cancer cells in athymic mice. Cell Growth Differ, 4(3), 193-201, 1993.
Dagnino, L, Pietenpol, J A, Yang, E Y, Moses, H L Transforming growth factor regulation of keratinocyte growth. Recent Results Cancer Res, 12815-29, 1993.
Johnson, M D, Jennings, M T, Gold, L I, Moses, H L Transforming growth factor-beta in neural embryogenesis and neoplasia. Hum Pathol, 24(5), 457-62, 1993.
Johnson, M D, Gold, L I, Moses, H L Evidence for transforming growth factor-beta expression in human leptomeningeal cells and transforming growth factor-beta-like activity in human cerebrospinal fluid. Lab Invest, 67(3), 360-8, 1992.
Moses, H L TGF-beta regulation of epithelial cell proliferation. Mol Reprod Dev, 32(2), 179-84, 1992.
Johnson, M D, Federspiel, C F, Gold, L I, Moses, H L Transforming growth factor-beta and transforming growth factor beta-receptor expression in human meningioma cells. Am J Pathol, 141(3), 633-42, 1992.
Lyons, R M, Miller, D A, Graycar, J L, Moses, H L, Derynck, R Differential binding of transforming growth factor-beta 1, -beta 2, and -beta 3 by fibroblasts and epithelial cells measured by affinity cross-linking of cell surface receptors. Mol Endocrinol, 5(12), 1887-96, 1991.
Pelton, R W, Johnson, M D, Perkett, E A, Gold, L I, Moses, H L Expression of transforming growth factor-beta 1, -beta 2, and -beta 3 mRNA and protein in the murine lung. Am J Respir Cell Mol Biol, 5(6), 522-30, 1991.
Pietenpol, J A, M??nger, K, Howley, P M, Stein, R W, Moses, H L Factor-binding element in the human c-myc promoter involved in transcriptional regulation by transforming growth factor beta 1 and by the retinoblastoma gene product. Proc Natl Acad Sci U S A, 88(22), 10227-31, 1991.
Pelton, R W, Saxena, B, Jones, M, Moses, H L, Gold, L I Immunohistochemical localization of TGF beta 1, TGF beta 2, and TGF beta 3 in the mouse embryo: expression patterns suggest multiple roles during embryonic development. J Cell Biol, 115(4), 1091-105, 1991.
Barnard, J A, Polk, W H, Moses, H L, Coffey, R J Production of transforming growth factor-alpha by normal rat small intestine. Am J Physiol, 261(6 Pt 1), C994-1000, 1991.
Moses, H L, Yang, E Y, Pietenpol, J A Regulation of epithelial proliferation by TGF-beta. Ciba Found Symp, 15766-74; discussion 75-80, 1991.
Jennings, M T, Maciunas, R J, Carver, R, Bascom, C C, Juneau, P, Misulis, K, Moses, H L TGF beta 1 and TGF beta 2 are potential growth regulators for low-grade and malignant gliomas in vitro: evidence in support of an autocrine hypothesis. Int J Cancer, 49(1), 129-39, 1991.
Moses, H L, Pietenpol, J A, M??nger, K, Murphy, C S, Yang, E Y TGF beta regulation of epithelial cell proliferation: role of tumor suppressor genes. Princess Takamatsu Symp, 22183-95, 1991.
Schwartz, H S, Butler, M G, Jenkins, R B, Miller, D A, Moses, H L Telomeric associations and consistent growth factor overexpression detected in giant cell tumor of bone. Cancer Genet Cytogenet, 56(2), 263-76, 1991.
Murphy, C S, Pietenpol, J A, M??nger, K, Howley, P M, Moses, H L c-myc and pRB: role in TGF-beta 1 inhibition of keratinocyte proliferation. Cold Spring Harb Symp Quant Biol, 56129-35, 1991.
Sipes, N J, Miller, D A, Bascom, C C, Winkler, J K, Matrisian, L M, Moses, H L Altered regulation of protein disulfide isomerase in cells resistant to the growth-inhibitory effects of transforming growth factor beta 1. Cell Growth Differ, 1(5), 241-6, 1990.
Pelton, R W, Hogan, B L, Miller, D A, Moses, H L Differential expression of genes encoding TGFs beta 1, beta 2, and beta 3 during murine palate formation. Dev Biol, 141(2), 456-60, 1990.
Beauchamp, R D, Lyons, R M, Yang, E Y, Coffey, R J, Moses, H L Expression of and response to growth regulatory peptides by two human pancreatic carcinoma cell lines. Pancreas, 5(4), 369-80, 1990.
Arteaga, C L, Coffey, R J, Dugger, T C, McCutchen, C M, Moses, H L, Lyons, R M Growth stimulation of human breast cancer cells with anti-transforming growth factor beta antibodies: evidence for negative autocrine regulation by transforming growth factor beta. Cell Growth Differ, 1(8), 367-74, 1990.
Pelton, R W, Dickinson, M E, Moses, H L, Hogan, B L In situ hybridization analysis of TGF beta 3 RNA expression during mouse development: comparative studies with TGF beta 1 and beta 2. Development, 110(2), 609-20, 1990.
Sipes, N J, Lyons, R M, Moses, H L Isolation and characterization of Kirsten murine sarcoma virus-transformed mouse keratinocytes resistant to transforming growth factor beta. Mol Carcinog, 3(1), 12-9, 1990.
Lyons, R M, Gentry, L E, Purchio, A F, Moses, H L Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin. J Cell Biol, 110(4), 1361-7, 1990.
Fava, R A, Casey, T T, Wilcox, J, Pelton, R W, Moses, H L, Nanney, L B Synthesis of transforming growth factor-beta 1 by megakaryocytes and its localization to megakaryocyte and platelet alpha-granules. Blood, 76(10), 1946-55, 1990.
Pietenpol, J A, Stein, R W, Moran, E, Yaciuk, P, Schlegel, R, Lyons, R M, Pittelkow, M R, M??nger, K, Howley, P M, Moses, H L TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains. Cell, 61(5), 777-85, 1990.
Moses, H L, Yang, E Y, Pietenpol, J A TGF-beta stimulation and inhibition of cell proliferation: new mechanistic insights. Cell, 63(2), 245-7, 1990.
Pelton, R W, Moses, H L The beta-type transforming growth factor. Mediators of cell regulation in the lung. Am Rev Respir Dis, 142(6 Pt 2), S31-5, 1990.
Barnard, J A, Lyons, R M, Moses, H L The cell biology of transforming growth factor beta. Biochim Biophys Acta, 1032(1), 79-87, 1990.
Pietenpol, J A, Holt, J T, Stein, R W, Moses, H L Transforming growth factor beta 1 suppression of c-myc gene transcription: role in inhibition of keratinocyte proliferation. Proc Natl Acad Sci U S A, 87(10), 3758-62, 1990.
Yang, E Y, Moses, H L Transforming growth factor beta 1-induced changes in cell migration, proliferation, and angiogenesis in the chicken chorioallantoic membrane. J Cell Biol, 111(2), 731-41, 1990.
Perkett, E A, Lyons, R M, Moses, H L, Brigham, K L, Meyrick, B Transforming growth factor-beta activity in sheep lung lymph during the development of pulmonary hypertension. J Clin Invest, 86(5), 1459-64, 1990.
Miller, D A, Pelton, R W, Derynck, R, Moses, H L Transforming growth factor-beta. A family of growth regulatory peptides. Ann N Y Acad Sci, 593208-17, 1990.
Lyons, R M, Moses, H L Transforming growth factors and the regulation of cell proliferation. Eur J Biochem, 187(3), 467-73, 1990.
Miller, D A, Lee, A, Matsui, Y, Chen, E Y, Moses, H L, Derynck, R Complementary DNA cloning of the murine transforming growth factor-beta 3 (TGF beta 3) precursor and the comparative expression of TGF beta 3 and TGF beta 1 messenger RNA in murine embryos and adult tissues. Mol Endocrinol, 3(12), 1926-34, 1989.
Bascom, C C, Wolfshohl, J R, Coffey, R J, Madisen, L, Webb, N R, Purchio, A R, Derynck, R, Moses, H L Complex regulation of transforming growth factor beta 1, beta 2, and beta 3 mRNA expression in mouse fibroblasts and keratinocytes by transforming growth factors beta 1 and beta 2. Mol Cell Biol, 9(12), 5508-15, 1989.
Pelton, R W, Nomura, S, Moses, H L, Hogan, B L Expression of transforming growth factor beta 2 RNA during murine embryogenesis. Development, 106(4), 759-67, 1989.
Miller, D A, Lee, A, Pelton, R W, Chen, E Y, Moses, H L, Derynck, R Murine transforming growth factor-beta 2 cDNA sequence and expression in adult tissues and embryos. Mol Endocrinol, 3(7), 1108-14, 1989.
Bascom, C C, Sipes, N J, Coffey, R J, Moses, H L Regulation of epithelial cell proliferation by transforming growth factors. J Cell Biochem, 39(1), 25-32, 1989.
Barnard, J A, Beauchamp, R D, Coffey, R J, Moses, H L Regulation of intestinal epithelial cell growth by transforming growth factor type beta. Proc Natl Acad Sci U S A, 86(5), 1578-82, 1989.
Skinner, M K, Moses, H L Transforming growth factor beta gene expression and action in the seminiferous tubule: peritubular cell-Sertoli cell interactions. Mol Endocrinol, 3(4), 625-34, 1989.
Coffey, R J, Sipes, N J, Bascom, C C, Graves-Deal, R, Pennington, C Y, Weissman, B E, Moses, H L Growth modulation of mouse keratinocytes by transforming growth factors. Cancer Res, 48(6), 1596-602, 1988.
Lyons, R M, Keski-Oja, J, Moses, H L Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium. J Cell Biol, 106(5), 1659-65, 1988.
Keski-Oja, J, Raghow, R, Sawdey, M, Loskutoff, D J, Postlethwaite, A E, Kang, A H, Moses, H L Regulation of mRNAs for type-1 plasminogen activator inhibitor, fibronectin, and type I procollagen by transforming growth factor-beta. Divergent responses in lung fibroblasts and carcinoma cells. J Biol Chem, 263(7), 3111-5, 1988.
Keski-Oja, J, Blasi, F, Leof, E B, Moses, H L Regulation of the synthesis and activity of urokinase plasminogen activator in A549 human lung carcinoma cells by transforming growth factor-beta. J Cell Biol, 106(2), 451-9, 1988.
Coffey, R J, Bascom, C C, Sipes, N J, Graves-Deal, R, Weissman, B E, Moses, H L Selective inhibition of growth-related gene expression in murine keratinocytes by transforming growth factor beta. Mol Cell Biol, 8(8), 3088-93, 1988.
Barnard, J A, Bascom, C C, Lyons, R M, Sipes, N J, Moses, H L Transforming growth factor beta in the control of epidermal proliferation. Am J Med Sci, 296(3), 159-63, 1988.
Keski-Oja, J, Postlethwaite, A E, Moses, H L Transforming growth factors in the regulation of malignant cell growth and invasion. Cancer Invest, 6(6), 705-24, 1988.
Keski-Oja, J, Lyons, R M, Moses, H L Immunodetection and modulation of cellular growth with antibodies against native transforming growth factor-beta 1. Cancer Res, 47(24 Pt 1), 6451-8, 1987.
Moses, H L, Coffey, R J, Leof, E B, Lyons, R M, Keski-Oja, J Transforming growth factor beta regulation of cell proliferation. J Cell Physiol Suppl, Suppl 51-7, 1987.