Stafford Lab

John M. Stafford

Assistant Professor
Department of Medicine
Division of Diabetes, Endocrinology, & Metabolism
and Molecular Physiology and Biophysics
Vanderbilt University Medical Center
7445 MRB4
Nashville, TN 37232-0475


1.  Scott, D.K., R.M. O’Doherty, J.M. Stafford, C.B. Newgard, and D.K. Granner. 1998. The repression of hormone-activated PEPCK gene expression by glucose is insulin independent but requires glucose metabolism. J Biol Chem. 273:24145-24151. PMID: 9727036.

2.   Wang, J.C.*, J.M. Stafford*, and D.K. Granner. 1998. SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4. J Biol Chem. 273:30847- 0850. PMID:9812974

3.   Pierreux, C.E., J.M. Stafford, D. Demonte, D.K. Scott, J. Vandenhaute, R.M. O’Brien, D.K. Granner, G.G. Rousseau, and F.P. Lemaigre. 1999. Antiglucocorticoid activity of hepatocyte nuclear factor-6. Proc Natl Acad Sci USA. 96:8961-8966. PMID:10430878.  PMCID: PMC17715.

4.   Wang, J.C., J.M. Stafford, D.K. Scott, C. Sutherland, and D.K. Granner. 2000.      The molecular physiology of hepatic nuclear factor 3 in the regulation of   gluconeogenesis. J Biol Chem. 275:14717-14721. PMID: 10799560.

5.   Stafford, J.M., M. Waltner-Law, D.K. Granner. 2001. Role of Accessory Factors and SRC1 in the regulation of PEPCK gene transcription by glucocorticoids.  J Biol Chem.  276:3811-3819. PMID: 11069927.

6.  Yoon, J.C., P. Puigserver, G. Chen, J. Donovan, Z. Wu, J. Rhee, G. Adelmant, J.M. Stafford, C. R. Kahn, D.K. Granner, C.B. Newgard, B.M. Spiegelman. 2001. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature. 413: 131-138. PMID:11557972. 

7.  Stafford, J.M., J. Wilkinson, J. Beechem, D.K. Granner. 2001. Accessory Factors Facilitate the Binding of Glucocorticoid Receptor to the PEPCK Gene Promoter. J Biol Chem. J. Biol. 276: 39885-39891. PMID: 11518712.

8.   Stafford, J. M. 2001. Role of Accessory Factors in the Regulation of Phosphoenolpyruvate Carboxykinase Gene Transcription by Glucocorticoids.  Dissertation.  ISBN: 0-493-14472-2.

9.   Stafford, J.M, F. Yu, R. Printz, A. Hasty, L. Swift, and K.D. Niswender. 2008. CNS neuropeptide Y signaling modulates VLDL triglyceride production. Diabetes.  57:1-9. PMID:  18332095.

 10. Wu, K., D. Cappel, M. Martinez, and J.M. Stafford. 2010.  Impaired-inactivation of FoxO1 contributes to glucose-mediated increases in serum VLDL.  Endocrinology. 115 (8): 3566-3576. PMID: 20501667.   PMCID: PMC294051.

11. M.N. Martinez, C.H. Emfinger, M. Overton, S. Hill, T.S. Ramaswamy, D.A. Cappel,  K. Wu, S. Fazio, D. Hachey, D.L. Tabb, J.M. Stafford.  2012. Obesity and altered carbohydrate metabolism impact HDL composition in CETP transgenic mice: A role for ovarian hormones.  Journal of Lipid Research.  Mar; 53 (3): 379-89. PMID:  22215797.

 12. Zhu, L., W.C. Brown, Q. Cai, P. Chambon, O.P. McGuinness, J.M. Stafford. 2013. Estrogen Treatment After Ovariectomy Protects Against Fatty Liver and May Improve Pathway-Selective Insulin Resistance. Diabetes. 62: 424-434. PMID: 22966069.

13. P. Luo, A. DeMatteo, Z. Wang, A. Wang, H-S Kim, A. Pozzi, J.M. Stafford, J.M. Luther, 2012. Aldosterone Deficiency Prevents High Fat Feeding-induced Hyperglycemia and Adipocyte Dysfunction in Mice. Diabetologia. 56 (4): p901-910. PMID: 23314847. PMCID: PMC3593801.

 14. J.M. Rojas, J.M Stafford, R.L. Printz, S. Saadat, M.K. Turney, A. Beck-Sickinger, K.D. Niswender. 2012. Central Nervous System Neuropeptide Y signaling via the Y1 receptor partially uncouples feeding behavior from lipoprotein metabolism in lean rats.Am J Physiol Endocrinol Metab. 2012 Dec 15;303(12):E1479-88. PubMed PMID: 23074243; PubMed Central PMCID: PMC3532466.

 15. D.A. Cappel, B.T. Palmisano C.H. Emfinger, M. Martinez, O.P McGuinness, J.M. Stafford. 2013. Cholesteryl Ester Transfer Protein Augments Insulin Sensitivity in Females with Obesity. Molecular Metabolism. 2: 457-467. PMID: 24327961. PMCID: PMC3854988 

16.  L. Zhu, C.H. Emfinger, B.T. Palmisano, J.M. Stafford. 2014. Estrogen signaling prevents diet-induced hepatic insulin resistance in males with obesity. Accepted, in press. American Journal of Physiology, Endocrinology and Metabolism.

17.   Y. Otero, J.M.Stafford, O.P Mc Guinness. 2014. Pathway-Selective Insulin Resistance and Metabolic Disease: The Importance of Nutrient Flux. Journal of Biological Chemistry. 289 (30), 20462-20469


18. D.A Cappel, B.P Palmisano, L. Lantier, D. Wasserman, J.M. Stafford. 2015. Cholesteryl Ester Transfer Protein augments exercise capacity with obesity in female mice. PLoS One 10(8):e0136915