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Vanderbilt Autonomic Dysfunction Center

Accomplishments of Autonomic Investigation at Vanderbilt

  • Role of adenosine in autonomic regulation
  • Attenuation of baroreflex function by caffeine
  • Discovery of dopamine-b-hydroxylase (DBH) deficiency
  • DBH deficiency successfully treated by dihydroxyphenylserine
  • Identification of the genomic basis of DBH deficiency
  • Recognition of prazosin's a subtype specificity by radioligand binding
  • Elucidation of the clinical spectrum of baroreflex failure
  • Intracellular signaling in response to a2 stimulation
  • Identification of structure of the choline transporter
  • Identification of structure of the norepinephrine transporter
  • Identification of structure of the serotonin transporter
  • Abnormal cardiac repolarization in autonomic dysfunction
  • Racial differences in autonomic pharmacology
  • Introduction of pharmacotherapies for autonomic failure:
    • fludrocortisone
    • caffeine
    • clonidine
    • yohimbine
    • phenylephrine nasal spray
    • nitroglycerin
    • phenylpropanolamine
    • inhaled ergotamine
  • Discovery of norepinephrine transporter deficiency
  • Recognition of the potent pressor effect of oral water in dysautonomias
  • Report of evidence supporting neuropathic postural tachycardia syndrome
  • Malignant vagotonia recognized as a presentation of baroreflex failure

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