Vanderbilt Addiction Center

Amphetamine Regulation of DAT Function in c.elegans

The dopamine transporter (DAT) is a plasma membrane transport protein expressed exclusively within a small subset of CNS neurons. It plays a crucial role in controlling dopamine-mediated neurotransmission and a number of associated behaviors. Our studies focuse on elucidating the role of the dopamine transporter in neurotoxicity and a number of CNS disorders, including drug abuse, attention deficit hyperactivity disorder (ADHD) and Parkinson disease.

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