Bih-Hwa Shieh, Ph.D.
Associate Professor Department of Pharmacology
Nashville, TN 37232
Tel. (615) 343-0441
News from VMC
- Vanderbilt and AstraZeneca agree to collaborate on neuroscience drug discovery
Chronicle of Higher Education - 1/17/2013
- VUMC and West Tennessee Healthcare announce affiliation agreement
WPLN Nashville Public Radio - 1/17/2013
- Lee Ann Ruffing, director of operations in Children’s Services at the Monroe Carell Jr. Children’s Hospital at Vanderbilt, named to Emerging Leaders
Nashville Post - 1/17/2013
- Clinical enterprise well prepared for future challenges: Balser
The Reporter - 6/29/2012
My research focuses on retinal degeneration. Retinal degeneration is characterized by the progressive loss of photoreceptors in the eye leading to blindness or a loss of vision. Specifically, we are interested in exploring the causes in an attempt to find ways to prevent this debilitating disease.
We use Drosophila as our experimental model organism for insights into mechanisms of degeneration. Inherited retinal degeneration in Drosophila has been explored for understanding similar processes in humans. In Drosophila, we employ a multi-disciplinary approach by combining molecular biological, cell biological, biochemical and genetics strategies to uncover the molecular basis underlying the degeneration process.
Currently, we are investigating the contribution of arrestin 1 and arrestin 2 in retinal degeneration. Both arrestins belong to the evolutionarily conserved family that plays a critical role to modulate the function of rhodopsin. In particular, we are exploring whether reversible phosphorylation of arrestins and rhodopsin affects the internalization of rhodopsin, which may orchestrate retinal degeneration.