VanderbiltHealth.com: For Patients and Visitors
Vanderbilt University Medical Center: For Employees, Researchers, and Students

Welcome!

 

Bih-Hwa Shieh, Ph.D.

 

Associate Professor Department of Pharmacology 
VUMC
402 RRB
Nashville, TN 37232
Tel. (615) 343-0441

 

 

Home

My research focuses on retinal degeneration. Retinal degeneration is characterized by the progressive loss of photoreceptors in the eye leading to blindness or a loss of vision. Specifically, we are interested in exploring the causes in an attempt to find ways to prevent this debilitating disease.

 

We use Drosophila as our experimental model organism for insights into mechanisms of degeneration. Inherited retinal degeneration in Drosophila has been explored for understanding similar processes in humans. In Drosophila, we employ a multi-disciplinary approach by combining molecular biological, cell biological, biochemical and genetics strategies to uncover the molecular basis underlying the degeneration process.

 

Currently, we are investigating the contribution of arrestin 1 and arrestin 2 in retinal degeneration. Both arrestins belong to the evolutionarily conserved family that plays a critical role to modulate the function of rhodopsin. In particular, we are exploring whether reversible phosphorylation of arrestins and rhodopsin affects the internalization of rhodopsin, which may orchestrate retinal degeneration.

 

 

 

Research Interests

Retinal degeneration

Rhodopsin

Arrestin

CaMKII

Visual signaling

Reversible phosphorylation

Scaffolding protein

Macromolecular complex

Drosophila Neurogenetics

 

Copyright © 2014 by Vanderbilt University Medical Center    |    1211 Medical Center Drive    |    Nashville, TN 37232    |    (615) 322-5000
Vanderbilt University is committed to principles of equal opportunity and affirmative action.
This page was last updated August 7, 2012 and is maintained by Bih-hwa Shieh