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Boothby Laboratory

Select Publications: Mark Boothby, M.D., Ph.D.

Boothby M, Williams CL. The goldilocks effect. Sci Transl Med, 4(163), 163fs42, 2012.  PMID:23220631

Lee K, Nam KT, Cho SH, Gudapati P, Hwang Y, Park DS, Potter R, Chen J, Volanakis E, Boothby M. Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia. J Exp Med, 209(4), 713-28, 2012.  PMID:22473959

Volanakis EJ, Boothby MR, Sherr CJ. Epigenetic regulation of the Ink4a-Arf (Cdkn2a) tumor suppressor locus in the initiation and progression of Notch1 driven T-ALL. Exp Hematol, 2012. PMID:23178376

Yang J, Kantrow S, Sai J, Hawkins OE, Boothby M, Ayers GD, Young ED, Demicco EG, Lazar AJ, Lev D, Richmond A. Ikk4a/Arf inactivation with activation of the NF-kB/IL-6 pathway is sufficient to drive the development and growth of angiosarcoma. Cancer Res, 72(18), 4682-95, 2012.  PMID:22836752

Zhuang G, Song W, Amato K, Hwang Y, Lee K, Boothby M, Ye F, Guo Y, Shyr Y, Lin L, Carbone DP, Brantley-Sieders DM, Chen J. Effects of cancer-associated EPHA3 mutations on lung cancer. J Natl Cancer Inst, 104(15), 1182-97, 2012. PMID:22829656

Cho SH, Ahn AK, Bhargava P, Lee CH, Eischen CM, McGuinness O, Boothby M. Glycolytic rate and lymphomagenesis depend on PARP14, an ADP ribosyltransferase of the B aggressive lymphoma (BAL) family. Proc Natl Acad Sci U S A, 108(38), 15972-7, 2011. PMCID:3179111

Gordy LE, Bezbradica JS, Flyak AI, Spencer CT, Dunkle A, Sun J, Stanic AK, Boothby MR, He YW, Zhao Z, Van Kaer L, Joyce S. IL-15 Regulates Homeostasis and Terminal Maturation of NKT Cells. J Immunol, 187(12), 6335-45, 2011. PMCID:3237743

Lee K, Gudapati P, Dragovic S, Spencer C, Joyce S, Killeen N, Magnuson MA, Boothby M. Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Immunity, 32(6), 743-53, 2010. PMID:20620941

Boothby M. The calculus of integrating differentiation: timing control of T-bet. Immunity, 30(5), 666-8, 2009. PMID:19464989

Cho SH, Goenka S, Henttinen T, Gudapati P, Reinikainen A, Eischen CM, Lahesmaa R, Boothby M. PARP-14, a member of the B aggressive lymphoma (BAL) family, transduces survival signals in primary B cells. Blood, 2009. PMCID:2656269

Adeeku E, Gudapati P, Mendez-Fernandez Y, Van Kaer L, Boothby M. Flexibility accompanies commitment of memory CD4 lymphocytes derived from IL-4 locus-activated precursors. Proc Natl Acad Sci U S A, 105(27), 9307-12, 2008. PMCID:2453725

Goenka S, Cho SH, Boothby M. Collaborator of Stat6 (CoaSt6)-associated poly(ADP-ribose) polymerase activity modulates Stat6-dependent gene transcription. J Biol Chem, 282(26), 18732-9, 2007. PMID:17478423

Goenka S, Boothby M. Selective potentiation of Stat-dependent gene expression by collaborator of Stat6 (CoaSt6), a transcriptional cofactor. Proc Natl Acad Sci U S A, 103(11), 4210-5, 2006. PMCID:1449672

Zhang F, Boothby M. T helper type 1-specific Brg1 recruitment and remodeling of nucleosomes positioned at the IFN-gamma promoter are Stat4 dependent. J Exp Med, 203(6), 1493-505, 2006. PMCID:2118309

Corn RA, Hunter C, Liou HC, Siebenlist U, Boothby M. Opposing roles for RelB and Bcl-3 in regulation of T-box expressed in T cells, GATA-3, and Th effector differentiation. J Immunol., 175(Aug 15 (4)), 2102-2110, 2005. PMID:16081776

Jones RG, Saibil SD, Pun JM, Elford AR, Bonnard M, Pellegrini M, Arya S, Parsons ME, Krawczyk CM, Gerondakis S, Yeh WC, Woodgett JR, Boothby MR, Ohashi PS. NF-kappaB couples protein kinase B/Akt signaling to distinct survival pathways and the regulation of lymphocyte homeostasis in vivo. J Immunol, 175(6), 3790-9, 2005. PMID:16148125

Stephenson LM, Park DS, Mora AL, Goenka S, Boothby M. Sequence motifs in IL-4R alpha mediating cell-cycle progression of primary lymphocytes. J Immunol, 175(8), 5178-85, 2005. PMID:16210622

Tong Y, Aune T, Boothby M. T-bet antagonizes mSin3a recruitment and transactivates a fully methylated IFN-gamma promoter via a conserved T-box half-site. Proc Natl Acad Sci U S A, 102(6), 2034-9, 2005. PMCID:548570

Stanic AK, Bezbradica JS, Park JJ, Van Kaer L, Boothby MR, Joyce S. Cutting edge: the ontogeny and function of Va14Ja18 natural T lymphocytes require signal processing by protein kinase C theta and NF-kappa B. J Immunol, 172(8), 4667-71, 2004. PMID:15067039

Stanic AK, Bezbradica JS, Park J, Matsuki N, Mora AL, Van Kaer L, Boothby MR, Joyce S. NF-kappaB controls cell fate specification, survival, and molecular differentiation of immunoregulatory natural T lymphocytes. J Immunol, 172(4), 2265-73, 2004. PMID:14764695

Stephenson L, Johns MH, Woodward E, Mora AL, Boothby, M. An IL-4R alpha allelic variant, I50, acts as a gain-of-function variant relative to V50 for Stat6, but not Th2 differentiation. J Immunol, 173(7), 4523-8, 2004. PMID:15383584

Aronica MA, McCarthy S, Swaidani S, Mitchell D, Goral M, Sheller JR, Boothby M. Recall Th2 response: Th1-resistant allergic susceptibility without biasing uncommitted CD4 T cells. Am J Respir Crit Care Med, 2003. PMID:14617509

Corn RA, Aronica MA, Zhang F, Tong Y, Stanley SA, Kim S, Stephenson L, Enerson B, McCarthy S, Mora A, Boothby, M. T cell-intrinsic requirement for NF-kappaB induction in postdifferentiation IFN-gamma production and clonal expansion in a Th1 response. J Immunol, 171, 1816-1824, 2003. PMID:12902482

Kelly-Welch AE, Hanson EM, Boothby MR, Keegan AD . Interleukin-4 and interleukin-13 signaling connections maps. Science, 300, 1527-8, 2003. PMID:12791978

Mora AL, Corn RA, Stanic AK, Goenka S, Aronica M, Stanley S, Ballard DW, Joyce S, Boothby M. Antiapoptotic function of NF-kappaB in T lymphocytes is influenced by their differentiation status: roles of Fas, c-FLIP, and Bcl-xL. Cell Death Differ, 10(9), 1032-44, 2003. PMID:12934078

Mora AL, Stephenson LM, Enerson BY, Jeehee K, Achsah D, Boothby M. New programming of IL-4 receptor signal transduction in activated T cells: Stat6 induction and Th2 differentiation mediated by IL-4Ralpha lacking cytoplasmic tyrosines.. J Immunol, 171: 1891-1900, 2003. PMID:12902491

Tato CM, Villarino A, Caamano JH, Jorge H, Boothby M, Hunter CA. Inhibition of NF-kappa B activity in T and NK cells results in defective effector cell expansion and production of IFN-gamma required for resistance to Toxoplasma gondii. J Immunol, 170, 3139-46, 2003. PMID:12626571

Yang L, Yamagata N, Yadav R, Brandon S, Courtney RL, Morrow JD, Shyr Y, Boothby M, Joyce S, Carbone DP, Breyer RM. Cancer-associated immunodeficiency and dendritic cell abnormalities mediated by the prostaglandin EP2 receptor. J Clin Invest, 111(5), 727-35, 2003. PMCID:151895

Zhou P, Hwang K, Palucki DA, Guo Z, Boothby M, Newell KA, Alegre M. Impaired NF-kappaB activation in T cells permits tolerance to primary heart allografts and to secondary donor skin grafts. Am J Transplant, 3, 139-47, 2003. PMID:12603209

Harlin H, Hwang K, Palucki DA, Kim O, Thompson CB, Boothby M, Alegre M. CTLA-4 engagement regulates NF-kappaB activation in vivo. Eur J Immunol, 32(8), 2095-104, 2002. PMID:12209621

Harlin H, Podack E, Boothby M, Alegre M. TCR-independent CD30 signaling selectively induces IL-13 production via a TNF receptor-associated factor/p38 mitogen-activated protein kinase-dependent mechanism. J Immunol, 169(5), 2451-9, 2002. PMID:12193714

Soutto M, Zhang F, Enerson B, Tong Y, Boothby M, Aune TM. A minimal IFN-gamma promoter confers Th1 selective expression. J Immunol, 169, 4205-12, 2002. PMID:12370350

Zamorano J, Mora AL, Boothby M, and Keegan AD. Regulation of IL-4-induced protection from apoptosis: Role of NF-kB proteins. Int'l. Immunol. 13: 1479-1487, 2001. PMID:11717189

Boothby, M. Specificity of sn50 for NF-kappa B. Nat Immunol, 2(6), 471-2, 2001. PMID:11376325

Boothby M, Mora AL, Aronica MA, Youn J, Sheller JR, Goenka S, Stephenson L. IL-4 signaling, gene transcription regulation, and the control of effector T cells. Immunol Res, 23, 179-191, 2001. PMID:11444383

Chen Y, Rosloniec E, Goral MI, Boothby M, Chen J. Redirection of T cell effector function in vivo and enhanced collagen-induced arthritis mediated by an IL-2R beta/IL-4R alpha chimeric cytokine receptor transgene. J Immunol, 166(6), 4163-9, 2001. PMID:11238667

Mora A, Youn J, Keegan A, and Boothby M. NF-kappa B/Rel participation in the lymphokine-dependent proliferation of T lymphoid cells. J Immunol, 166, 2218-2227, 2001. PMID:11160275

Mora, A L, Stanley, S, Armistead, W, Chan, A C, Boothby, M. Inefficient ZAP-70 phosphorylation and decreased thymic selection in vivo result from inhibition of NF-kappaB/Rel. J Immunol, 167(10), 5628-35, 2001. PMID:11698434

Aronica MA, Goenka S, and Boothby M. IL-4-dependent induction of BCL-2 and BCL-x(L) in activated T lymphocytes through a STAT6- and PI 3-kinase-independent pathway. Cytokine, 12, 578-587, 2000. PMID:10843732

Aronica MA, Mora AL, Mitchell DB, Finn PW, Johnson JE, Sheller JR, Boothby MR. Preferential role for NF-kappa B/Rel signaling in the type 1 but not type 2 T cell-dependent immune response in vivo. J Immunol, 163(9), 5116-24, 1999. PMID:10528218

Aune TM, Mora AL, Kim S, Boothby M, Lichtman AH. Costimulation reverses the defect in IL-2 but not effector cytokine production by T cells with impaired IkappaBalpha degradation. J Immunol, 162(10), 5805-12, 1999. PMID:10229814

Goenka S, Youn J, Dzurek LM, Schindler U, Yu-Lee LY, Boothby M. Paired Stat6 C-terminal transcription activation domains required both for inhibition of an IFN-responsive promoter and trans-activation. J Immunol, 163(9), 4663-72, 1999. PMID:10528163

Mora AL, Chen D, Boothby M, Rubin DH. Lineage-specific differences among CD8+ T cells in their dependence of NF-kappa B/Rel signaling. Eur J Immunol, 29(9), 2968-80, 1999. PMID:10508271

Powell WC, Fingleton B, Wilson CL, Boothby M, Matrisian LM. The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis. Curr Biol, 9(24), 1441-7, 1999. PMID:10607586

Seetharaman R, Mora AL, Nabozny G, Boothby M, Chen J. Essential role of T cell NF-kappa B activation in collagen-induced arthritis. J Immunol, 163(3), 1577-83, 1999. PMID:10415062

Boothby MR, Mora AL, Scherer DC, Brockman JA, Ballard DW. Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-kappaB. J Exp Med, 185(11), 1897-907, 1997. PMCID:2196335

Wang D, Zamorano J, Keegan AD, Boothby M. HMG-I(Y) phosphorylation status as a nuclear target regulated through insulin receptor substrate-1 and the I4R motif of the interleukin-4 receptor. J Biol Chem, 272(40), 25083-90, 1997. PMID:9312117

Wang DZ, Ray P, Boothby M. Interleukin 4-inducible phosphorylation of HMG-I(Y) is inhibited by rapamycin. J Biol Chem, 270(39), 22924-32, 1995. PMID:7559428

Rothman P, Li SC, Gorham B, Glimcher L, Alt F, Boothby M. Identification of a conserved lipopolysaccharide-plus-interleukin-4-responsive element located at the promoter of germ line epsilon transcripts. Mol Cell Biol, 11(11), 5551-61, 1991. PMCID:361925

Liou HC, Boothby MR, Finn PW, Davidon R, Nabavi N, Zeleznik-Le NJ, Ting JP, Glimcher LH. A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter. Science, 247(4950), 1581-4, 1990. PMID:2321018

Boothby M, Liou HC, Glimcher LH. Differences in DNA sequence specificity among MHC class II X box binding proteins. J Immunol, 142(3), 1005-14, 1989. PMID:2492326

Gravallese EM, Boothby MR, Smas CM, Glimcher LH. A lipopolysaccharide-induced DNA-binding protein for a class II gene in B cells is distinct from NF-kappa B. Mol Cell Biol, 9(8), 3184-92, 1989. PMCID:362362

Boothby M, Gravallese E, Liou HC, Glimcher LH. A DNA binding protein regulated by IL-4 and by differentiation in B cells. Science, 242(4885), 1559-62, 1988. PMID:3144043

Liou HC, Boothby MR, Glimcher LH. Distinct cloned class II MHC DNA binding proteins recognize the X box transcription element. Science, 242(4875), 69-71, 1988. PMID:3140376

Boime I, Boothby M, Darnell RB, Policastro P. Structure and expression of human placental hormone genes. Adv Exp Med Biol, 205, 267-80, 1986. PMID:3788716

Hoshina M, Boothby MR, Hussa RD, Pattillo RA, Camel HM, Boime I. Segregation patterns of polymorphic restriction sites of the gene encoding the alpha subunit of human chorionic gonadotropin in trophoblastic disease. Proc Natl Acad Sci U S A, 81(8), 2504-7, 1984. PMCID:345090

Boothby M, Kukowska J, Boime I. Imbalanced synthesis of human choriogonadotropin alpha and beta subunits reflects the steady state levels of the corresponding mRNAs. J Biol Chem, 258(15), 9250-3, 1983. PMID:6192128

Policastro P, Ovitt CE, Hoshina M, Fukuoka H, Boothby MR, Boime I. The beta subunit of human chorionic gonadotropin is encoded by multiple genes. J Biol Chem, 258(19), 11492-9, 1983. PMID:6194155

Boothby M, Ruddon RW, Anderson C, McWilliams D, Boime I. A single gonadotropin alpha-subunit gene in normal tissue and tumor-derived cell lines. J Biol Chem, 256(10), 5121-7, 1981. PMID:6262319

Kohler PO, Riser M, Hardin J, Boothby M, Boime I, Norris J, Siciliano MJ. Chorionic gonadotropin synthesis and gene assignment in human:mouse hybrid cells. Adv Exp Med Biol, 138, 405-18, 1981. PMID:7342721

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