Targeted Request for Proposals
Exploring the mechanisms for HIV persistence and the potential for HIV eradication
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Eligibility: Doctoral-level investigators at nonprofit institutions worldwide
Available Funding: $250,000 Total Costs ($208,333 maximum direct costs plus up to 20% for indirect costs)
Performance Period: Two years starting February 1, 2012.
Deadline: Letters of Intent must be submitted no later than October 25, 2011
Background: This RFP solicits proposals relevant to exploring the mechanisms for HIV persistence and the potential for HIV eradication. Highly active antiretroviral therapy (HAART) has significantly impacted the health of individuals infected with HIV-1. However, if therapy is interrupted, there is a rapid resumption of viral replication. Understanding the mechanisms by which the virus is able to persist in the face of therapy is necessary in order to identify strategies that may interrupt viral persistence and ultimately lead to viral eradication. amfAR wishes to support basic, clinical, and especially translational research exploring the mechanisms whereby HIV infection persists; the chronic nature of viral reservoirs and latency; and barriers to the eradication of HIV, with the potential goal of ultimately eliminating HIV infection.
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