Cortez Lab


Recent Publications

Couch, F., Bansbach, C.E., Driscoll, R., Luzwick, J., Glick, G.G, Betous, R., Carroll, C.M., Yung, S.Y., Qin, J. Cimprich, K.A., and Cortez, D. (2012) ATR phosphorylates SMARCAL1 to prevent aberrant replication fork processing. Genes and Development, in press

Betous, R., Couch, F.B., Mason, A.C., Glick, G.G., Eichman, B.F., Manosas, M. and Cortez, D. (2013) Substrate-selective repair and restart of replication forks by DNA translocases. Cell Reports 3:1-12

Carroll, C., Badu-Nkansah, A., Hunley, T., Baradaran-Heravi, A., Cortez, D., Frangoul, H. (2013) Schimke immunoosseous dysplasia associated with undifferentiated carcinoma and a novel SMARCAL1 mutation in a child. Pediatric Blood and Cancer, published online DOI:10.1002/pbc.24542

Betous, R., Glick, G.G., Zhao, R., Cortez, D. (2013) Identification and characterization of SMARCAL1 protein complexes. Plos One 8:e63149; PMCID: PMC3650004

Nagarajan, P., Ge, Z., Sirbu, B., Doughty, C., Agudelo, P, Annunziato, A., Cortez, D., Kenner, L., Parthun, M.R. (2013) “Histone Acetyltransferase 1 is Required for Mammalian Development, Genome Stability and the Processing of Newly Synthesized Histones H3 and H4. PLOS Genetics 9:e1003518

Betous, R., Mason, A.C., Rambo, R.P., Bansbach, C.E., Badu-Nkansah, A., Sirbu, B.M., Eichman, B.F., Cortez, D. (2012) SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replication, Genes and Development, 26:151-62

Sirbu, B.M., Couch, F.B., Cortez, D. (2012) Monitoring the spatiotemporal dynamics of proteins at replication forks and in assembled chromatin using Ioslation of Proteins on Nascent DNA (iPOND). Nature Protocols, 7:594-605

Sirbu, B.M., Couch, F.B., Feigerle, J.T., Bhaskara, S., Hiebert, S.W., Cortez D. (2011) Analysis of protein dynamics at active, stalled and collapsed replication forks. Genes and Development 25:1320-1327

Nam, E.A. Zhao, R., Glick, G.G., Bansbach, C., Friedman, D.B., Cortez, D. (2011) T1989 phosphorylation is a marker of active Ataxia Telangiectasia-mutated and Rad3-Related (ATR) kinase. in press

Nam, E.A. and Cortez, D. (2011) ATR signaling: more than meeting at the fork. Biochemical Journal 436:527-36

Bansbach CE, Boerkoel CF, Cortez D. (2010) SMARCAL1 and replication stress: An explanation for SIOD? Nucleus 1:245-248

Yu, D.S., Zhao, R., Hsu, E.L., Cayer, J., Ye, F., Guo, Y., Shyr, Y., Cortez, D. (2010) CDK9-Cyclin K Functions in the Replication Stress Response. EMBO Reports 11:876-82

Wiltshire, TD, Lovejoy, CA, Wang, T, Xia, F, O'Connor, MJ, Cortez, D. (2010) Sensitivity to poly (ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair. J Biol Chem, 285:14565-14571

Lovejoy C.A., Xu X., Bansbach C.E., Glick G.G., Zhao R., Ye F., Sirbu B.M., Titus L.C., Shyr Y., Cortez D., (2009) Functional genomic screens identify CINP as a genome maintenance protein. Proc Natl Acad Sci, 106:19304-19309

Bansbach C.E., Betous R., Lovejoy C.A., Glick G.G., Cortez D. (2009) The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks. Genes and Development, 23:2405-2414

Nam E. and Cortez D. (2009) SOSS1/2: Sensors of single-stranded DNA at a break. Mol Cell, 14:258-9

Lovejoy C.A. and Cortez D. (2009) Common mechanisms of PIKK regulation. DNA Repair, 8:1004-8

Mordes D.A., Nam E., Cortez D., (2008) Dpb11 activates the Mec1-Ddc2 complex. Proc Natl Acad Sci USA, 105:18730-4

Xu, X., Vaithiyalingam, S., Glick, G.G., Mordes, D.A., Chazin, W.J., Cortez, D., (2008) The basic cleft of RPA70N binds multiple checkpoint proteins, including Rad9, to regulate ATR signaling. Mol Cell Biol, 28, 7345-53

Mordes, D.A., and Cortez, D. (2008) Activation of ATR and related PIKKs. Cell cycle, 18:2809-12

Cimprich, KA, and Cortez, D. (2008) ATR: An essential regulator of genome integrity. Nature Reviews Molecular Cell Biology, 9:616-627

Mordes, D.A., Glick, G.G., Zhao, R., Cortez, D. (2008) TopBP1 activates ATR through ATRIP and a PIKK regulatory domain. Genes and Development, 22:1478-89

Bhaskara, S., Chyla, B.J, Amann, J.M., Knutson, S.K., Cortez, D., Sun, Z-W., Hiebert, S.W. (2008) Deletion of Histone Deacetylase 3 Reveals Critical Roles in S Phase Progression and DNA Damage Control. Molecular Cell, 11:71-72

Myers, J.S., Zhao, R., Xu, X., Ham,. A-J. L., Cortez, D. (2007) Cdk2-dependent phosphorylation of ATRIP regulates the G2/M checkpoint response to DNA damage. Cancer Research, 67:6685-6690

Ball, H.L., Ehrahdt, M., Mordes, D., Glick, G., Chazin W.J., Cortez, D. (2007) Function of a Conserved Checkpoint Recruitment Domain in ATRIP Proteins. Mol Cell Biol. 27:3367-77

Chen, X., Zhao, R., Glick, G.G., Cortez, D. (2007) Function of the ATR N-terminal domain revealed by an ATM/ATR chimera. Exp Cell Res. 313:1667-74

Lovejoy, C.L., Lock, K., Yenamandra, A., Cortez, D. (2006) DDB1 maintains genome integrity through regulation of Cdt1. Mol Cell Biol. 26:7977-90

Myers, J.S., Cortez, D. (2006) Rapid Activation of ATR by Ionizing Radiation Requires ATM and Mre11. J Biol Chem, 281(14), 9346-50

Ball, H.L., Cortez, D. (2005) ATRIP oligomerization is required for ATR-dependent checkpoint signaling. J Biol Chem, 280(36), 31390-6

Ball, H.L., Myers, J.S., Cortez, D. (2005) ATRIP Binding to RPA-ssDNA Promotes ATR-ATRIP Localization but Is Dispensable for Chk1 Phosphorylation. Mol Biol Cell, 16, 2372-2381


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