Digestive Disease Research Center

GI Organoids Subcore

Research Assistant: Kimberly Watt
Core Services:
  • Utilizes the Immortomouse and the Saito method ofintestinal organoid production as a source for  conditionally immortalized cell lines and fully normal cell lines with other trnsgenic mouse modesl that are relevent to a particular digestive disease
  • Establishes conditionally-immortalized and normal epithelial cell lines from gastrointestinal mucosa, the pancreas or liver
  • Fully characterizes these cell lines with respect to their epithelial phenotype, the presence of the specific genetic mutation of interest and the presence of tissue-specific markers
  • Has established a “bank” of early passage cells for use by DDRC investigators

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