Digestive Disease Research Center

Novel Cell Line Development Subcore

Core Services:
  • Utilizes the Immortomouse as a source of a conditional immortalizing gene in crosses with other transgenic mouse models that are relevant to a particular digestive disease
  • Establishes conditionally-immortalized epithelial cell lines from gastrointestinal mucosa, pancreas orliver
  • Fully characterizes these cell lines with respect to their epithelial phenotype, the presence of the specific genetic mutation of interest and the presence of tissue-specific markers
  • Has established a “bank” of early passage cells for use by DDRC investigators

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