.

Fesik Lab

Available Positions

Research Professor

This position requires a Ph.D. and relevant postdoctoral experience. The ideal candidate would have experience in drug discovery at a major Pharmaceutical company. He/she will be responsible for conducting and directing biological experiments as part of a team effort to discover new cancer therapeutics. Some of the specific areas of research include: validating potential cancer targets, developing and performing biochemical and cell-based assays, elucidating mechanisms of compound action, and identifying the genetic determinants of drug sensitivity/resistance to guide clinical trials.
 

Drug Discovery Scientist I

Please apply for this position on Vanderbilt Job website: http://www.vanderbilt.edu/work-at-vanderbilt/. Please search by the job title: Drug Discovery Scientist I.

Description
 
The Fesik lab is a multi-disciplinary group in the Department of Biochemistry at Vanderbilt University, dedicated to oncology drug discovery.  We have an exciting opportunity for a talented and motivated cell biologist to join this dynamic group.  This individual will work closely with students, post-docs, biologists, and chemists to screen compounds in cell-based assays, develop new assays and techniques, and contribute to the discovery of new targets for cancer drug discovery. 
 
Key Functions and Expected Performances:

  • Conduct cell-based and plate-based assays to enable drug discovery efforts.  Use established protocols and existing assays to measure growth inhibition, apoptosis, regulation of transcription, and inhibition of signaling pathways; assays include fluorescence- and luminescence-based formats, such as ELISA, In-cell Western, and FRET.  Screen compounds in single concentration and dose-response schemes, analyze and report data.
  • Contribute to the design and development of novel assays to measure the functional consequences of inhibition of a number of diverse targets, including assays to measure disruption of protein-protein interactions, anchorage-independent growth, migration, invasion, and signaling.
  • Conduct research projects to understand the mechanism of action of novel targeted therapies identified in our group.  This may include screening cancer cell lines and tumors to understand the genetic predictors of response to these targeted agents.
  • Suggest, design, and implement research projects to identify and validate new targets for cancer drug discovery. Experiments may include target silencing by RNAi, target overexpression, and compound treatment of cancer cell lines.
  • Remain current on literature, ideas, and relevant laboratory techniques in oncology and drug discovery.
  • Contribute to the effective operation of the lab by sharing the responsibilities of preparing buffers and reagents, ordering supplies, and maintaining equipment.

 Minimum Requirements:

This position requires a Ph.D. in cell or cancer biology or a Masters degree with a minimum of 5 years experience in oncology/cancer biology.

The candidate must be well-versed in standard cell biology techniques, including mammalian cell culture, transfection protocols, Western blotting techniques, fluorescence microscopy, and PCR. Candidate must be able to design and troubleshoot assays and experiments independently. Clear written and oral communication skills, excellent data analysis capabilities, and proficiency with curve-fitting and graphing programs are essential. Applicants with previous compound screening or drug discovery experience in a pharmaceutical or biotech company will be given special consideration.

 

Postdoctoral Research Fellows in Cell and Cancer Biology

The Fesik Lab at Vanderbilt University invites applications for postdoctoral research fellows in cell and cancer biology to discover novel therapeutics for the treatment of cancer. The cell/cancer biology team supports these efforts by developing and performing assays for testing compounds, validating cancer targets, investigating compound mechanism of action, and profiling small molecules in defined cell lines and tumor types to inform clinical trial design.

The successful candidate will work closely within a multi-disciplinary team comprised of structural biologists, medicinal chemists, and cell/cancer biologists. Examples of the type of studies to be performed by the candidate include:
 

  • Conduct cell-based and plate-based assays to enable compound progression.  Use established protocols and existing assays to measure inhibition of protein:protein interactions, growth inhibition, apoptosis, regulation of transcription, and inhibition of signaling pathways; assays include fluorescence- and luminescence-based formats, such as ELISA, In-cell Western, and FRET. Screen compounds in single concentration and dose-response schemes, analyze and report data. 
  • Contribute to the design and development of novel assays to measure the functional consequences of inhibition of a number of diverse targets, especially those involved in apoptosis and epigenetics.
  • Conduct research projects to understand the mechanism of action of novel targeted therapies identified in our group.  This may include screening cancer cell lines and tumors to understand the genetic predictors of response to these targeted agents.
  • Participate in research projects to identify and validate new targets for cancer drug discovery.  Experiments will include target silencing by RNAi, target overexpression, and compound treatment of cancer cell lines.


Candidates should possess a recent Ph.D. in cancer biology, cell biology, genetics, or a closely-related discipline. Candidates should be skilled in basic cell biology techniques, including asceptic cell culture, Western blotting, RNAi technology, FACS. Candidates with expertise in the fields of apotosis regulation or epigenetics will receive special consideration.

If interested, please provide a cover letter describing your relevant experience, a curriculum vitae, and a short research summary of your work to stephen.fesik@vanderbilt.edu.