Maureen Gannon, Ph.D.
Department of Medicine, Division of Diabetes, Endocrinology and Metabolism
Department of Molecular Physiology and Biophysics
Department of Cell and Developmental Biology
Vanderbilt University Medical Center
2213 Garland Avenue
MRB IV 7435
Nashville, TN 37232
office: (615) 936-2676
lab: (615) 936-2683
fax: (615) 936-1667
Ph.D. in Cell and Molecular Biology from University of Pennsylvania
B.S. in Biology with concentration in Genetics from Duke University
FoxM1, a transcription factor that promotes cell cycle progression, is expressed exclusively in proliferating cells. Murine FoxM1 is required for postnatal beta cell expansion and beta cell proliferation after partial pancreatectomy and during pregnancy.
In both rodents and humans, the capacity of beta cell replication diminishes with age. This reduction correlates with a decrease in Foxm1 expression. To determine whether increased FoxM1 activity can rejuvenate the replicative potential of beta cells, I am generating transgenic mice that express an inducible, hypermorphic form of FoxM1 in the beta cell. To investigate the factors that are expressed differentially in proliferating beta cells compared to quiescent beta cells, I am deriving a mouse that expresses an RFP-tagged version of FoxM1 within the endogenous Foxm1 locus. These mice will be crossed to MIP-GFP mice, and doubly fluorescent (proliferating beta cells) as well as green fluorescent cells (non-proliferating beta cells) will be isolated by FACS. RNA from both populations will be analyzed by microarray.
Ahmed MN. Suliman HB. Folz RJ. Nozik-Grayck E. Golson ML. Mason SN. Auten RL. Extracellular superoxide dismutase protects lung development in hyperoxia-exposed newborn mice. American Journal of Respiratory & Critical Care Medicine. 167(3):400-5, 2003 Feb 1.
Kang SK. Rabbani ZN. Folz RJ. Golson ML. Huang H. Yu D. Samulski TS. Dewhirst MW. Anscher MS. Vujaskovic Z. Overexpression of extracellular superoxide dismutase protects mice from radiation-induced lung injury. International Journal of Radiation Oncology, Biology, Physics. 57(4):1056-66, 2003 Nov 15.
Golson ML. Sanger JM. Sanger JW. Inhibitors arrest myofibrillogenesis in skeletal muscle cells at early stages of assembly. Cell Motility & the Cytoskeleton. 59(1):1-16, 2004 Sep.
Rabbani ZN. Anscher MS. Folz RJ. Archer E. Huang H. Chen L. Golson ML. Samulski TS. Dewhirst MW. Vujaskovic Z. Overexpression of extracellular superoxide dismutase reduces acute radiation induced lung toxicity. BMC Cancer. 5(1):59, 2005.
Zelent D. Golson ML. Koeberlein B. Quintens R. van Lommel L. Buettger C. Weik-Collins H. Taub R. Grimsby J. Schuit F. Kaestner KH. Matschinsky FM. A glucose sensor role for glucokinase in anterior pituitary cells. Diabetes. 55(7):1923-9, 2006 Jul.
Gao N. White P. Doliba N. Golson ML. Matschinsky FM. Kaestner KH. Foxa2 controls vesicle docking and insulin secretion in mature Beta cells. Cell Metabolism. 6(4):267-79, 2007 Oct.
Golson ML, Loomes KM, Oakey R, Kaestner KH. Ductal malformation and pancreatitis in mice caused by conditional Jag1 deletion. Gastroenterology. 136(5):1761-71.e1. 2009 May.
Golson ML, Le Lay J, Gao N, Brämswig N, Loomes KM, Oakey R, May CL, White P, Kaestner KH. Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas. Mech Dev. 126(8-9):687-99. 2009 Aug-Sep;
Golson, M.L. Ackermann Misfeldt, A., Kopsombut, U.G., Petersen, C.P. and Gannon, M. High fat diet regulation of b-cell proliferation and b-cell mass. Open Endocrinology. 4, 66-77. 2010