Maureen Gannon, Ph.D.
Department of Medicine, Division of Diabetes, Endocrinology and Metabolism
Department of Molecular Physiology and Biophysics
Department of Cell and Developmental Biology
Vanderbilt University Medical Center
2213 Garland Avenue
MRB IV 7435
Nashville, TN 37232
office: (615) 936-2676
lab: (615) 936-2683
fax: (615) 936-1667
Hometown: Goshen, Indiana
Education: B.A. in Biology from Hanover College
Research Topic: I am interested in factors that regulate β cell proliferation in the settings of obesity and aging. My project will focus on the roles of FoxM1, a transcription factor important for cell cycle progression, and EP3, the prostaglandin receptor that inhibits adenylyl cyclase via a Gi coupled mechanism. I will focus on understanding the role that each of these proteins play in β cell proliferation and mass expansion during high fat diet and aging. I will also determine if EP3 signaling affects FoxM1 activity and whether FoxM1 is required for the effects observed during EP3 inhibition.
Hometown: Franklin, TN
Education: BA in Molecular Biology from Colgate University
I am interested in better understanding the role of the transcription factor HNF6 in pancreas development and disease. A collaborator of ours has shown that HNF6 alone, or to an increased extent with Pdx1, can activate Ngn3 transcription. I will determine if this ability can also initiate endocrine differentiation in a human cell model. Additionally, the mouse Hnf6 knockout develops severe pancreatitis, a precursor state for pancreatic cancer. I will determine the role of HNF6 as a tumor suppressor in a pancreatic cancer model.