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Maureen Gannon, Ph.D.
Associate Professor

Department of Medicine, Division of Diabetes, Endocrinology and Metabolism


Department of Molecular Physiology and Biophysics

Department of Cell and Developmental Biology

Vanderbilt University Medical Center
2213 Garland Avenue
MRB IV 7435
Nashville, TN 37232

office: (615) 936-2676    
lab: (615) 936-2683        
fax: (615) 936-1667

Graduate Students

Kimberly Gooding

Hometown:
Summerfield, NC

 
Education:
B.S. in Biology from University of North Carolina Chapel Hill
 
 
Research Topic:
I am interested in assessing the ability of CTGF to promote β cell regeneration in the islet, specifically in the setting of extensive β cell ablation, which will be followed with a "treatment" of increased CTGF expression using an inducible doxycycline system. We hypothesize this excess CTGF induction will promote β cell regeneration via proliferation and thus islet survival.
 

 

Bethany Carboneau

bethany

Hometown: Goshen, Indiana

Education: B.A. in Biology from Hanover College

Research Topic: I am interested in factors that regulate β cell proliferation in the settings of obesity and aging.  My project will focus on the roles of FoxM1, a transcription factor important for cell cycle progression, and EP3, the prostaglandin receptor that inhibits adenylyl cyclase via a Gi coupled mechanism. I will focus on understanding the role that each of these proteins play in β cell proliferation and mass expansion during high fat diet and aging. I will also determine if EP3 signaling affects FoxM1 activity and whether FoxM1 is required for the effects observed during EP3 inhibition. 

 

Peter Kropp

Hometown: Franklin, TN

peter

Education:  BA in Molecular Biology from Colgate University

Research Topic:

I am interested in better understanding the role of the transcription factor HNF6 in pancreas development and disease. A collaborator of ours has shown that HNF6 alone, or to an increased extent with Pdx1, can activate Ngn3 transcription. I will determine if this ability can also initiate endocrine differentiation in a human cell model. Additionally, the mouse Hnf6 knockout develops severe pancreatitis, a precursor state for pancreatic cancer. I will determine the role of HNF6 as a tumor suppressor in a pancreatic cancer model.

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This page was last updated April 10, 2013 and is maintained by Maureen Gannon