Gannon Lab

Peer reviewed articles

Henley KD, Gooding KA, Economides AN, Gannon M. Inactivation of the dual Bmp/Wnt inhibitor Sostdc1 enhances pancreatic islet function. Am J Physiol Endocrinol Metab. 303(6):E752-61, 2012

 Uma Gunasekaran, Courtney W. Hudgens, Brian T. Wright, Matthew F. Maulis, and Maureen Gannon. Differential regulation of embryonic and adult beta cells. Cell Cycle, 11(13), pp2431-2442, 2012 

Guney M, Petersen CP, Boustani A, Duncan MR, Gunasekaran U, Menon R, Warfield C, Grotendorst GR, Means AL, Economides AN, Gannon M. Connective tissue growth factor acts within both endothelial cells and β cells to promote proliferation of developing β cells. PNAS, 108(37), pp15242-15247, 2011 

 Moore MC, Menon R, Coate KC, Gannon M, Smith MS, Farmer B, Williams PE. Diet-induced impaired glucose tolerance and gestational diabetes in the dog. Journal of Applied Physiology, 110:458-467, 2011

Wicksteed B, Brissova M, Yan W, Opland DM, Plank JL, Reinert RB, Dickson LM, Tamarina NA, Philipson LH, Shostak A, Bernal-Mizrachi E, Elghazi L, Roe MW, Myers MG Jr, Gannon M, Powers AC, Dempsey PJ. Conditional gene targeting in mouse pancreatic β-Cells: analysis of ectopic Cre transgene expression in the brain. Diabetes 59(12), pp3090-8, 2010

Vellanki R, Zhang L, Guney MA, Rocheleau J, Gannon M, Volchuk A. OASIS/CREB3L1 Induces Expression of Genes Involved in Extracellular Matrix Production But Not Classical Endoplasmic Reticulum Stress Response Genes in Pancreatic β-Cells. Endocrinology 151(9), pp4146-4157, 2010

Zhang*, H, Zhang*, J, Pope, CF, Crawford, LA, Vasavada, RC, Jagasia, SM, Gannon, M. Gestational diabetes resulting from impaired β-cell compensation in the absence of FoxM1, a novel downstream effector of placental lactogen.  Diabetes. 2009

Zhang*, H, Tweedie, EA, Pope, CF, Washington, MK, Hipkens, S, Means, AL, Path, G, Seufert, J, Costa, RH, Leiter, AB, Magnuson, MA, Gannon, M.  Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation. Mechanisms of Development. 2009.

 Crawford, LA, Guney, MA, Oh, YA, Deyound, RA, Valenzuela, DM, Murphey, AJ, Yancopoulos, GD, Lyons, KM, Bringstock, DR, Economides, A, Gannon, M.  Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis. Mol Endo, 23(3), 324-36, 2009

Elghazi, L, Weiss, AJ, Barker, DJ, Callaghan, J, Staloch, L, Sandgren, EP, Gannon, M, Adsay, VN, Bernal-Mizrachi, E.  Regulation of pancreas plasticity and malignant transformation by Akt signaling.  Gastroenterology, 136(3), 1091-103, 2009

Ackermann Misfeldt, A, Costa, RH, Gannon, M. Beta-cell proliferation, but not neogenesis, following 60% partial pancreatectomy is impaired in the absence of FoxM1. Diabetes, 57(11):3069-77, 2008

Wilding, CL, Tweedie Ables, E, Oh, YA, Boone, B, Levy, S, Gannon, M. Gene expression profiling of a mouse model of pancreatic islet dysmorphogenesis. PLoS One, 3(2), e1611, 2008

Gannon, M, Ables, ET, Crawford, L, Lowe, D, Offield, MF, Magnuson, MA, Wright, CV. Pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Dev Biol, 314(2), 406-17, 2008

Ackermann, AM, Gannon, M.  Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion. J. Mol Endo, 38(1-2), 193-206, 2007

Kanetsuna, Y, Takahashi, K, Nagata, M, Gannon, MA, Breyer, MD, Harris, RC, Takahashi, T. Deficiency of endothelial nitric-oxide synthase confers susceptibility to diabetic nephropathy in nephropathy-resistant inbred mice. Am J Pathol, 170(5), 1473-84, 2007

Wiebe, PO, Korminsh, JD, Roper, VT, Fujitani, Y, Alston, NI, Zaret, KS, Wright, CV, Stein, RW, Gannon, M. Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 Expression. Mol Cell Biol, 27(11), 4093-204, 2007

Boyer, DF, Fujitani, Y, Gannon, M, Powers, AC, Stein, RW, Wright, CV. Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression. Dev Biol, 298(2), 616-31, 2006

Brissova, M, Shostak, A, Shiota, M, Wiebe, PO, Poffenberger, G, Kantz, J, Chen, Z, Carr, C, Jerome, WG, Chen, J, Baldwin, HS, Nicholson, W, Bader, DM, Jetton, T, Gannon, M, Powers, AC. Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function. Diabetes, 55(11), 2974-85, 2006

Kanetsuna, Y, Hirano, K, Nagata, M, Gannon, MA, Takahashi, K, Harris, RC, Breyer, MD, Takahashi, T. Characterization of diabetic nephropathy in a transgenic model of hypoinsulinemic diabetes. Am J Physiol Renal Physiol, 291(6), F1315-22, 2006

Tweedie, E, Artner, I, Crawford, L, Poffenberger, G, Thorens, B, Stein, R, Powers, AC, Gannon, M.  Maintenance of hepatic nuclear factor 6 in postnatal islets impairs terminal differentiation and function of beta cells.  Diabetes, 55(12), 3264-70, 2006

Zhang, H, Ackermann, AM, Gusarova, GA, Lowe, D, Feng, X, Kopsombut, UG, Costa, RH, Gannon, M. The Foxm1 Transcription Factor is Required to Maintain Pancreatic Beta Cell Mass. Mol Endocrinol, 20(8), 1853-66, 2006

Fujitani, Y., S. Fujitani, D. Boyer, M. Gannon, Y. Kawaguchi, M.K. Ray, M. Shiota, R.W. Stein, M.A. Magnuson, and C.V.E. Wright. Targeted deletion of cis-regulatory region for pdx1 reveals dosage responses of foregut differentiation, pancreas organogenesis, and function. Genes and Development, 20(2), 253-66, 2006.

Zhang, H, Fujitani, Y, Wright, CV, Gannon, M. Efficient recombination in pancreatic islets by a tamoxifen-inducible Cre-recombinase. Genesis, 42(3), 210-7, 2005

Brissova, Marcela, Fowler, Michael, Wiebe, Peter, Shostak, Alena, Shiota, Masakazu, Radhika, Aramandla, Lin, P Charles, Gannon, Maureen, Powers, Alvin C. Intraislet endothelial cells contribute to revascularization of transplanted pancreatic islets. Diabetes, 53(5), 1318-25, 2004

Frigeri, Claudia, Martin, Cyrus C, Svitek, Christina A, Oeser, James K, Hutton, John C, Gannon, Maureen, O''Brien, Richard M. The proximal islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen promoter is sufficient to initiate but not maintain transgene expression in mouse islets in vivo. Diabetes, 53(7), 1754-64, 2004.

Brissova, Marcela, Shiota, Masakazu, Nicholson, Wendell E, Gannon, Maureen, Knobel, Susan M, Piston, David W, Wright, Christopher V E, Powers, Alvin C. Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion. J Biol Chem, 277(13), 11225-32, 2002

Kawaguchi, Yoshiya, Cooper, Bonnie, Gannon, Maureen, Ray, Michael, MacDonald, Raymond J, Wright, Christopher V E. The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat Genet, 32(1), 128-34, 2002

Samaras, Susan E, Cissell, Michelle A, Gerrish, Kevin, Wright, Christopher V E, Gannon, Maureen, Stein, Roland. Conserved sequences in a tissue-specific regulatory region of the pdx-1 gene mediate transcription in Pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6. Mol Cell Biol, 22(13), 4702-13, 2002

Zhang, Peichuan, McGrath, Barbara, Li, Sheng'ai, Frank, Ami, Zambito, Frank, Reinert, Jamie, Gannon, Maureen, Ma, Kun, McNaughton, Kelly, Cavener, Douglas R. The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Mol Cell Biol, 22(11), 3864-74, 2002

Dutta, S, Gannon, M, Peers, B, Wright, C, Bonner-Weir, S, Montminy, M. PDX:PBX complexes are required for normal proliferation of pancreatic cells during development. Proc Natl Acad Sci U S A, 98(3), 1065-70, 2001

Gannon, M, Gamer, L W, Wright, C V. Regulatory regions driving developmental and tissue-specific expression of the essential pancreatic gene pdx1. Dev Biol, 238(1), 185-201, 2001

Gannon, M, Gilday, D, Rifkind, A B. TCDD induces CYP1A4 and CYP1A5 in chick liver and kidney and only CYP1A4, an enzyme lacking arachidonic acid epoxygenase activity, in myocardium and vascular endothelium. Toxicol Appl Pharmacol, 164(1), 24-37, 2000

Gannon, M, Herrera, P L, Wright, C V. Mosaic Cre-mediated recombination in pancreas using the pdx-1 enhancer/promoter. Genesis, 26(2), 143-4, 2000

Gannon, M, Ray, M K, Van Zee, K, Rausa, F, Costa, R H, Wright, C V. Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function. Development, 127(13), 2883-95, 2000

Gannon, M, Shiota, C, Postic, C, Wright, C V, Magnuson, M. Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas. Genesis, 26(2), 139-42, 2000

Gerrish, K, Gannon, M, Shih, D, Henderson, E, Stoffel, M, Wright, C V, Stein, R. Pancreatic beta cell-specific transcription of the pdx-1 gene. The role of conserved upstream control regions and their hepatic nuclear factor 3beta sites. J Biol Chem, 275(5), 3485-92, 2000

Song, S Y, Gannon, M, Washington, M K, Scoggins, C R, Meszoely, I M, Goldenring, J R, Marino, C R, Sandgren, E P, Coffey, R J, Wright, C V, Leach, S D. Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha. Gastroenterology, 117(6), 1416-26, 1999

Wu, K L, Gannon, M, Peshavaria, M, Offield, M F, Henderson, E, Ray, M, Marks, A, Gamer, L W, Wright, C V, Stein, R. Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene. Mol Cell Biol, 17(10), 6002-13, 1997

Gilday, D, Gannon, M, Yutzey, K, Bader, D, Rifkind, A B. Molecular cloning and expression of two novel avian cytochrome P450 1A enzymes induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Biol Chem, 271(51), 33054-9, 1996

Gannon, M, Bader, D. Initiation of cardiac differentiation occurs in the absence of anterior endoderm. Development, 121(8), 2439-50, 1995

Yutzey, K, Gannon, M, Bader, D. Diversification of cardiomyogenic cell lineages in vitro. Dev Biol, 170(2), 531-41, 1995

Nakai, K, Ward, A M, Gannon, M, Rifkind, A B. Beta-naphthoflavone induction of a cytochrome P-450 arachidonic acid epoxygenase in chick embryo liver distinct from the aryl hydrocarbon hydroxylase and from phenobarbital-induced arachidonate epoxygenase. J Biol Chem, 267(27), 19503-12, 1992

Wang, G, Higgins, P J, Gannon, M, Staiano-Coico, L. Transforming growth factor-beta 1 acts cooperatively with sodium n-butyrate to induce differentiation of normal human keratinocytes. Exp Cell Res, 198(1), 27-30, 1992

Rifkind, A B, Gannon, M, Gross, S S. Arachidonic acid metabolism by dioxin-induced cytochrome P-450: a new hypothesis on the role of P-450 in dioxin toxicity. Biochem Biophys Res Commun, 172(3), 1180-8, 1990

Review Articles

Gunasekaran, U., Gannon, M. Type 2 Diabetes and the Aging Beta Cell. AGING, Vol 3, No 6, pp 565-575, 2011

Ackermann, AM, Gannon, M. Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion. J Mol Endocrinol, 38(2), 193-206, 2007

Wilding, L, Gannon, M. The role of pdx1 and HNF6 in proliferation and differentiation of endocrine precursors. Diabetes Metab Res Rev, 20(2), 114-23, 2004 

Gannon, M. Molecular genetic analysis of diabetes in mice. Trends Genet, 17(10), S23-8, 2001 

Melnik, N, Yutzey, K E, Gannon, M, Bader, D. Commitment, differentiation, and diversification of avian cardiac progenitor cells. Ann N Y Acad Sci, 752, 1-8, 1995

Comments / News & Views

Book Chapters

Gannon, M., K. Gerrish, R. Stein and C.V.E. Wright. (2000). Role of pdx-1 in pancreatic development. Frontiers in Diabetes: Molecular pathogenesis of MODYs. F.M. Matschinsky and M.A. Magnuson, Eds. S. Karger AG.  Basel, Switzerland. pp. 166-180.

Gannon, M. and C.V.E. Wright. (1999). Endoderm patterning and organogenesis. Cell Lineage and Fate Determination. Sally Moody, Ed. Academic Press. San Diego, CA. pp. 583-615.

Gannon, M, Bader, D. Avian cardiac progenitors: methods for isolation, culture, and analysis of differentiation. Methods Cell Biol, 52, 117-32, 1997