Maureen Gannon, Ph.D.
Department of Medicine, Division of Diabetes, Endocrinology and Metabolism
Department of Molecular Physiology and Biophysics
Department of Cell and Developmental Biology
Vanderbilt University Medical Center
2213 Garland Avenue
MRB IV 7435
Nashville, TN 37232
office: (615) 936-2676
lab: (615) 936-2683
fax: (615) 936-1667
Wu F, Li R, Umino Y, Kaczynski TJ, Sapkota D, Li S, Xiang M, Fliesler SJ, Sherry DM, Gannon M, Solessio E, Mu X. Onecut1 is essential for horizontal cell genesis and retinal integrety. J Neurosci. 2013 Aug 7
Guney M, Petersen CP, Boustani A, Duncan MR, Gunasekaran U, Menon R, Warfield C, Grotendorst GR, Means AL, Economides AN, Gannon M. Connective tissue growth factor acts within both endothelial cells and β cells to promote proliferation of developing β cells. PNAS, 108(37), pp15242-15247, 2011
Wicksteed B, Brissova M, Yan W, Opland DM, Plank JL, Reinert RB, Dickson LM, Tamarina NA, Philipson LH, Shostak A, Bernal-Mizrachi E, Elghazi L, Roe MW, Myers MG Jr, Gannon M, Powers AC, Dempsey PJ. Conditional gene targeting in mouse pancreatic β-Cells: analysis of ectopic Cre transgene expression in the brain. Diabetes 59(12), pp3090-8, 2010
Vellanki R, Zhang L, Guney MA, Rocheleau J, Gannon M, Volchuk A. OASIS/CREB3L1 Induces Expression of Genes Involved in Extracellular Matrix Production But Not Classical Endoplasmic Reticulum Stress Response Genes in Pancreatic β-Cells. Endocrinology 151(9), pp4146-4157, 2010
Zhang*, H, Zhang*, J, Pope, CF, Crawford, LA, Vasavada, RC, Jagasia, SM, Gannon, M. Gestational diabetes resulting from impaired β-cell compensation in the absence of FoxM1, a novel downstream effector of placental lactogen. Diabetes. 2009
Zhang*, H, Tweedie, EA, Pope, CF, Washington, MK, Hipkens, S, Means, AL, Path, G, Seufert, J, Costa, RH, Leiter, AB, Magnuson, MA, Gannon, M. Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation. Mechanisms of Development. 2009.
Crawford, LA, Guney, MA, Oh, YA, Deyound, RA, Valenzuela, DM, Murphey, AJ, Yancopoulos, GD, Lyons, KM, Bringstock, DR, Economides, A, Gannon, M. Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis. Mol Endo, 23(3), 324-36, 2009
Elghazi, L, Weiss, AJ, Barker, DJ, Callaghan, J, Staloch, L, Sandgren, EP, Gannon, M, Adsay, VN, Bernal-Mizrachi, E. Regulation of pancreas plasticity and malignant transformation by Akt signaling. Gastroenterology, 136(3), 1091-103, 2009
Gannon, M, Ables, ET, Crawford, L, Lowe, D, Offield, MF, Magnuson, MA, Wright, CV. Pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Dev Biol, 314(2), 406-17, 2008
Kanetsuna, Y, Takahashi, K, Nagata, M, Gannon, MA, Breyer, MD, Harris, RC, Takahashi, T. Deficiency of endothelial nitric-oxide synthase confers susceptibility to diabetic nephropathy in nephropathy-resistant inbred mice. Am J Pathol, 170(5), 1473-84, 2007
Wiebe, PO, Korminsh, JD, Roper, VT, Fujitani, Y, Alston, NI, Zaret, KS, Wright, CV, Stein, RW, Gannon, M. Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 Expression. Mol Cell Biol, 27(11), 4093-204, 2007
Boyer, DF, Fujitani, Y, Gannon, M, Powers, AC, Stein, RW, Wright, CV. Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression. Dev Biol, 298(2), 616-31, 2006
Brissova, M, Shostak, A, Shiota, M, Wiebe, PO, Poffenberger, G, Kantz, J, Chen, Z, Carr, C, Jerome, WG, Chen, J, Baldwin, HS, Nicholson, W, Bader, DM, Jetton, T, Gannon, M, Powers, AC. Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function. Diabetes, 55(11), 2974-85, 2006
Kanetsuna, Y, Hirano, K, Nagata, M, Gannon, MA, Takahashi, K, Harris, RC, Breyer, MD, Takahashi, T. Characterization of diabetic nephropathy in a transgenic model of hypoinsulinemic diabetes. Am J Physiol Renal Physiol, 291(6), F1315-22, 2006
Tweedie, E, Artner, I, Crawford, L, Poffenberger, G, Thorens, B, Stein, R, Powers, AC, Gannon, M. Maintenance of hepatic nuclear factor 6 in postnatal islets impairs terminal differentiation and function of beta cells. Diabetes, 55(12), 3264-70, 2006
Zhang, H, Ackermann, AM, Gusarova, GA, Lowe, D, Feng, X, Kopsombut, UG, Costa, RH, Gannon, M. The Foxm1 Transcription Factor is Required to Maintain Pancreatic Beta Cell Mass. Mol Endocrinol, 20(8), 1853-66, 2006
Fujitani, Y., S. Fujitani, D. Boyer, M. Gannon, Y. Kawaguchi, M.K. Ray, M. Shiota, R.W. Stein, M.A. Magnuson, and C.V.E. Wright. Targeted deletion of cis-regulatory region for pdx1 reveals dosage responses of foregut differentiation, pancreas organogenesis, and function. Genes and Development, 20(2), 253-66, 2006.
Brissova, Marcela, Fowler, Michael, Wiebe, Peter, Shostak, Alena, Shiota, Masakazu, Radhika, Aramandla, Lin, P Charles, Gannon, Maureen, Powers, Alvin C. Intraislet endothelial cells contribute to revascularization of transplanted pancreatic islets. Diabetes, 53(5), 1318-25, 2004
Frigeri, Claudia, Martin, Cyrus C, Svitek, Christina A, Oeser, James K, Hutton, John C, Gannon, Maureen, O''Brien, Richard M. The proximal islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen promoter is sufficient to initiate but not maintain transgene expression in mouse islets in vivo. Diabetes, 53(7), 1754-64, 2004.
Brissova, Marcela, Shiota, Masakazu, Nicholson, Wendell E, Gannon, Maureen, Knobel, Susan M, Piston, David W, Wright, Christopher V E, Powers, Alvin C. Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion. J Biol Chem, 277(13), 11225-32, 2002
Kawaguchi, Yoshiya, Cooper, Bonnie, Gannon, Maureen, Ray, Michael, MacDonald, Raymond J, Wright, Christopher V E. The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat Genet, 32(1), 128-34, 2002
Samaras, Susan E, Cissell, Michelle A, Gerrish, Kevin, Wright, Christopher V E, Gannon, Maureen, Stein, Roland. Conserved sequences in a tissue-specific regulatory region of the pdx-1 gene mediate transcription in Pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6. Mol Cell Biol, 22(13), 4702-13, 2002
Zhang, Peichuan, McGrath, Barbara, Li, Sheng'ai, Frank, Ami, Zambito, Frank, Reinert, Jamie, Gannon, Maureen, Ma, Kun, McNaughton, Kelly, Cavener, Douglas R. The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Mol Cell Biol, 22(11), 3864-74, 2002
Dutta, S, Gannon, M, Peers, B, Wright, C, Bonner-Weir, S, Montminy, M. PDX:PBX complexes are required for normal proliferation of pancreatic cells during development. Proc Natl Acad Sci U S A, 98(3), 1065-70, 2001
Gannon, M, Gilday, D, Rifkind, A B. TCDD induces CYP1A4 and CYP1A5 in chick liver and kidney and only CYP1A4, an enzyme lacking arachidonic acid epoxygenase activity, in myocardium and vascular endothelium. Toxicol Appl Pharmacol, 164(1), 24-37, 2000
Gannon, M, Ray, M K, Van Zee, K, Rausa, F, Costa, R H, Wright, C V. Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function. Development, 127(13), 2883-95, 2000
Gannon, M, Shiota, C, Postic, C, Wright, C V, Magnuson, M. Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas. Genesis, 26(2), 139-42, 2000
Gerrish, K, Gannon, M, Shih, D, Henderson, E, Stoffel, M, Wright, C V, Stein, R. Pancreatic beta cell-specific transcription of the pdx-1 gene. The role of conserved upstream control regions and their hepatic nuclear factor 3beta sites. J Biol Chem, 275(5), 3485-92, 2000
Song, S Y, Gannon, M, Washington, M K, Scoggins, C R, Meszoely, I M, Goldenring, J R, Marino, C R, Sandgren, E P, Coffey, R J, Wright, C V, Leach, S D. Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha. Gastroenterology, 117(6), 1416-26, 1999
Wu, K L, Gannon, M, Peshavaria, M, Offield, M F, Henderson, E, Ray, M, Marks, A, Gamer, L W, Wright, C V, Stein, R. Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene. Mol Cell Biol, 17(10), 6002-13, 1997
Gilday, D, Gannon, M, Yutzey, K, Bader, D, Rifkind, A B. Molecular cloning and expression of two novel avian cytochrome P450 1A enzymes induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Biol Chem, 271(51), 33054-9, 1996
Nakai, K, Ward, A M, Gannon, M, Rifkind, A B. Beta-naphthoflavone induction of a cytochrome P-450 arachidonic acid epoxygenase in chick embryo liver distinct from the aryl hydrocarbon hydroxylase and from phenobarbital-induced arachidonate epoxygenase. J Biol Chem, 267(27), 19503-12, 1992
Wang, G, Higgins, P J, Gannon, M, Staiano-Coico, L. Transforming growth factor-beta 1 acts cooperatively with sodium n-butyrate to induce differentiation of normal human keratinocytes. Exp Cell Res, 198(1), 27-30, 1992
Rifkind, A B, Gannon, M, Gross, S S. Arachidonic acid metabolism by dioxin-induced cytochrome P-450: a new hypothesis on the role of P-450 in dioxin toxicity. Biochem Biophys Res Commun, 172(3), 1180-8, 1990
Gannon, M., K. Gerrish, R. Stein and C.V.E. Wright. (2000). Role of pdx-1 in pancreatic development. Frontiers in Diabetes: Molecular pathogenesis of MODYs. F.M. Matschinsky and M.A. Magnuson, Eds. S. Karger AG. Basel, Switzerland. pp. 166-180.
Gannon, M. and C.V.E. Wright. (1999). Endoderm patterning and organogenesis. Cell Lineage and Fate Determination. Sally Moody, Ed. Academic Press. San Diego, CA. pp. 583-615.