2008 Ph.D. Pharmacology, Louisiana State University Health Sciences, New Orleans LA
2003 Bachelor of Science - Cell and Molecular Biology, Tulane University, New Orleans LA
Coming from a purely pharmacological background with an emphasis on G protein-coupled receptors (GPCR) my general research interest lies in understanding how this very effective signaling module has been adapted to controlling signaling events across all systems in the body, by dissecting out the details through which they have diversified and distinguished themselves in each tissue. My post-doctoral work is focused on characterizing the signaling of a unique group of G protein-coupled receptors (GPCRs), the protease activated receptors (PAR) in two primary tissues: platelets and Human Umbilical Vein Endothelial Cells (HUVECs). I am interested in defining conventional paradigms of signaling through these receptors, differences in signaling pathways initiated by different receptor subtypes, and also functional selectivity displayed by these receptor in response to endogenous ligands and also demonstrating how these signaling paradigms contribute to primary cell physiology.
Duvernay MT, Dong C, Zhang X, Robitaille M, Hébert TE, Wu G. A single conserved leucine residue in the first intracellular loop regulates ER export of G protein-coupled recetors. Traffic. 2009, 10: 552-66
Duvernay MT, Dong C, Zhang X, Zhou F, Nichols CD, Wu G. Anterograde trafficking of G protein-coupled receptors: function of the C-terminal F(X)6LL motif in export from the endoplasmic reticulum. Mol Pharmacol. 2009, 75:751-61
Dong C, Filipeanu CM, Duvernay MT, Wu G. Regulation of G protein-coupled receptor export trafficking. (Invited review). Biochim Biophys Acta. 2007, 1768:853-70.
Zhou F, Filipeanu CM, Duvernay MT, Wu G. Cell-surface targeting of alpha2-adrenergic receptors -- inhibition by a transport deficient mutant through dimerization. Cell Signal. 2006, 18:18-27.
Duvernay MT, Filipeanu CM, Wu G. The regulatory mechanisms of export trafficking of G protein-coupled receptors. (Invited Review). Cell Signal. 2005, 17:1457-65.
Duvernay MT, Zhou F, Wu G. A conserved motif for the transport of G protein-coupled receptors from the Endoplasmic Reticulum to the Cell Surface. J Biol Chem. 2004, 279:30741-50.