Yun Young (Susan) Yim, graduate student
Department of Pharmacology
Vanderbilt University Medical Center
2200 Pierce Avenue
Nashville, TN 37232
B.S. Biochemistry/Chemistry, University of California, San Diego, 2010 (La Jolla, CA).
The activation of Gi/o-coupled GPCRs plays an important role in regulating neurotransmitter release through the action of G-protein βγ subunits (Gβγ). Gβγ subunits directly interact with the exocytotic machinery such as Soluble NSF Attachment Protein Receptor (SNARE) complex to inhibit transmitter release by limiting both the number and duration of fusion events. However, the specific molecular requirements and mechanism of Gβγ -SNARE interaction are unknown. Using biophysical and biochemical approaches, I am trying to understand how synaptic transmission can be modulated by Gβγ subunits in calcium dependent and independent manners. I am also interested in the Gβγ -SNARE interactions of many neurological and psychiatric disorders.