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James May Lab

Dr James M May, Principal Investigator

Dr May received a Bachelors degree in Biology from Yale College and then attended medical school at Vanderbilt. Following a residency at Johns Hopkins Hospital in Baltimore, a Fellowship at the University of Washington in Seattle, and research at the Medical College of Virginia, Dr May returned to Vanderbilt to set up a research lab in 1986. Dr May is a practicing clinician in endocrinology at the VA but devotes the majority of his time to research.

Recent publications (from 136):
1. Harrison, F.E., Hosseini, A.H., Dawes, S.M., Weaver, S., May, J.M. Ascorbic acid attenuates scopolamine-induced spatial learning deficits in the water maze. Behav Brain Res. 205, 550-558, 2009.
2. Harrison FE, Allard, J., Bixler, R., Usoh, C., Li, L., May, J. M., & McDonald, M. P. (2009) Antioxidants and cognitive training interact to affect oxidative stress and memory in APP/PSEN1 mice. Nutritional Neuroscience 12, 203-218, 2009.
3. Harrison,F.E., May,J.M., and McDonald,M.P. Vitamin C deficiency increases basal exploratory activity but decreases scopolamine-induced activity in APP/PSEN1 transgenic mice. Pharmacol. Biochem. Behav. 94:543-552, 2010.
4. May,J.M. Assessing the reductive capacity of cells by measuring the recycling of ascorbic and lipoic acids. Methods Mol. Biol. 610:229-243, 2010.
5. May,J.M., and Qu,Z.C. Chelation of intracellular iron enhances endothelial barrier function: A role for vitamin C? Arch. Biochem. Biophys. 500:162-168, 2010.
6. Harrison,F.E., Dawes,S.M., Meredith,M.E., Babaev,V.R., Li,L., and May,J.M. Low vitamin C and increased oxidative stress and cell death in mice that lack the sodium-dependent vitamin C transporter SVCT2. Free Radic. Biol. Med. 49:821-829, 2010. PMC2916678
7. Harrison,F.E., Green,R.J., Dawes,S.M., and May,J.M. Vitamin C distribution and retention in the mouse brain. Brain Res. 1348C:181-186, 2010.
8. May,J.M., Li,L., and Qu,Z.C. Oxidized LDL up-regulates the ascorbic acid transporter SVCT2 in endothelial cells. Mol. Cell Biochem., in press, 2010.
9. Babaev,V.R., Li,L., Shah,S., Fazio,S., Linton,M.F., and May,J.M. Combined Vitamin C and Vitamin E Deficiency Worsens Early Atherosclerosis in Apolipoprotein E-Deficient Mice. Arterioscler. Thromb. Vasc. Biol., in press 2010.
10. Harrison,F.E., Meredith,M.E., Dawes,S.M., Saskowski,J.L., and May,J.M. Low ascorbic acid and increased oxidative stress in gulo(-/-) mice during development. Brain Res., in press, 2010.

Current Funding:

  • R01 NS057674-01A2; 2008-2012; NIH/NINDS; Vitamin C Transporters in the Brain
    The project examines the role of the neuronal SVCT2 transporter in maintaining brain ascorbate concentrations and in protecting against oxidant stress generated in mouse models of combined deficiencies of vitamins C and E.
  •  R01 DK050435-14; 2006-2011; NIH/NIDDK; Ascorbic Acid Function and Metabolism
    The goal of this project is to study the role of ascorbate in the development of atherosclerosis related to mouse models and the cells involved, including endothelial cells, macrophages, and smooth muscle cells.

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