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Li Laboratory

INHERITED NEUROPATHY (CMT), MYELIN BIOLOGY AND MOTOR NEURON DISEASE

Neurology Department, Vanderbilt University

 

Research Focus

Dr. Li is specialized in neuromuscular diseases with particular research interest in inherited neuropathies (also called Charcot-Marie-Tooth disease or CMT), myelin biology and motor neuron diseases. Disabilities in many neurological diseases, including inherited neuropathies and motor neuron diseases, are usually caused by one of the two pathophysiological processes: de-/dysmyelination and/or axonal degeneration. Our laboratory investigates the molecular mechanisms underlying the two pathological processes at different levels of biological system, including primary culture neurons/Schwann cells, genetically manipulated rodent models, and human subjects with inherited neuropathies. This approach allows us not only to understand the diseases better, but also provides opportunity to observe the basic functions of specific genes and their encoded proteins in vivo.

Our laboratory is equipped with instruments that permit us to perform most experiments in morphological, molecular biology, genetics and protein chemistry. In addition, we have full access to a variety of state-of-the-art core facilities in Vanderbilt, including proteonomic, transgenic, human genomic, cell imaging and structure biology cores.

Vanderbilt University is a prestigious institution that provides a superb environment fostering the career development of academic trainees. Members in our laboratory will have opportunities to interact with excellent faculty across several disciplines who are collaborating with us.

Our laboratory research is currently funded by the National Institutes of Health, Muscular Dystrophy Association, and Veterans Affairs.

Dr. Li's Vanderbilt faculty page:

https://medschool.mc.vanderbilt.edu/facultydata/php_files/part_dept/show_part.php?id3=18004

 

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This page was last updated August 8, 2012 and is maintained by Audra Hamilton