Christine Konradi, Ph.D
Education
1987 Ph.D. University of Vienna, Biology
Postdoctoral Training
| Year | Title | Speciality/Discipline | Place of Training |
| 1984-1986 | Fellow | Neurochemistry | Ludwig Boltzmann Institute of Clinical Neurobiology, Lainz Hospital, Vienna |
| 1986-1988 | Postdoctoral fellow | Neurochemistry | Department of Psychiatry University of Würzburg, Germany |
| 1989 | Postdoctoral fellow | Neuropharmacology | Neurology Department, University of Medicine and Dentistry of New Jersey |
| 1989-1990 | Postdoctoral fellow | Neurogenetics | Massachusetts General Hospital, Harvard Medical School |
| 1991-1992 | Postdoctoral fellow | Molecular Neurobiology | Massachusetts General Hospital, Harvard Medical School |
Academic Appointments
| Year | Academic Title | Institution |
| 1992-1994 | Instructor in Psychiatry | Harvard Medical School |
| 1994-2001 | Assistant Professor of Psychiatry | Harvard Medical School |
| 2001-2006 | Associate Professor of Psychiatry | Harvard Medical School |
| 2006- | Professor of Psychiatry | Vanderbilt University Medical Center |
Research Programs
| Years covered | Funding source | Grant title |
| 1999-2004 | NIDA; RO1 | Psychostimulant regulation of neural gene expression |
| 2001-2006 | NIMH; RO1 | Role of Nucleus Accumbens CREB in Depression |
| 2000-2002 | NIMH; RO3 | Hippocampal Gene expression in schizophrenia |
| 2003-2005 | private | Mitochondrial function in Bipolar Disorder |
| 2004-2008 | NINDS | Levodopa dyskinesia and striatal neuroplasticity |
| 2004-2006 | NIDA | Adolescent drug exposure and adult PFC function |
| 2004-2008 | NIMH | Hippocampus in Schizophrenia and Bipolar Disorder |
| 2005-2008 | NIMH | Antipsychotic drug effects in limbic structures |
Original Articles (Peer reviewed)
1. Konradi C, Riederer P, Youdim MBH. Hydrogen peroxide enhances the activity of monoamine oxidase type-B but not of type-A: a pilot study. Journal of Neural Transmission 1986 [Suppl]; 22: 61-73.
2. Riederer P, Konradi C, Schay V, Kienzl E, Birkmayer G, Danielczyk W, Sofic E, Youdim MBH. Localization of MAO-A and MAO-B in human brain: a step in understanding the therapeutic action of L-deprenyl. Advances in Neurology 1987; 45: 111-118.
3. Konradi C, Riederer P, Jellinger K, Denney R. Cellular action of MAO inhibitors. Journal of Neural Transmission 1987 [Suppl]; 25: 15-25.
4. Konradi C, Jellinger K, Riederer P, Nagatsu T. Histochemistry of MAO-A and MAO-B in the locus coeruleus of the Mongolian gerbil. Journal of Neural Transmission 1987; 70: 369-376.
5. Riederer P, Rausch WD, Schmidt B, Kruzik P, Konradi C, Sofic E, Danielczyk W, Fischer M, Ogris E. Biochemical fundamentals of Parkinson's disease. Mount Sinai Journal of Medicine 1988; 55: 21-28.
6. Konradi C, Svoma E, Jellinger K, Riederer P, Denney R, Thibault J. Topographic immunocytochemical mapping of monoamine oxidase- A, monoamine oxidase-B and tyrosine hydroxylase in human post mortem brain stem. Neuroscience 1988; 26: 791-802.
7. Danielczyk W, Streifler M, Konradi C, Riederer P, Moll G. Platelet MAO-B activity and the psychopathology of Parkinson's disease, senile dementia and multi-infarction dementia. Acta Psychiatr Scand 1988; 78: 730-736.
8. Fritze J, Koronakis P, Konradi C, Riederer P. Isoelectric focusing of monoamine oxidase subtypes as identified by MAO inhibitors. European J Pharmacol 1989; 172: 147-154.
9. Kornhuber J, Konradi C, Mack-Burkhardt F, Riederer P, Heinsen H, Beckmann H. Ontogenesis of monoamine oxidase-A and -B in the human brain frontal cortex. Brain Res 1989; 499: 81-86.
10. Konradi C, Kornhuber J, Frölich L, Fritze J, Heinsen H, Beckmann H, Schulz E, Riederer P. Demonstration of monoamine oxidase-A and -B in the human brainstem by a histochemical technique. Neuroscience 1989; 33: 383-400.
11. Kornhuber J, Mack-Burkhardt F, Konradi C, Fritze J, Riederer P. Effect of antemortem and postmortem factors on [3H]MK-801 binding in the human brain: transient elevation during early childhood. Life Scie 1989; 45: 745-749.
12. Riederer P, Konradi C, Hebenstreit G. Neurochemical perspectives of the function of monoamine oxidases. Psychiatrische Praxis 1989; 16: 7-10.
13. Riederer P, Konradi C, Hebenstreit G, Youdim MBH. Neurochemical perspectives of the function of monoamine oxidase. Acta Neurol Scand 1989; 126: 41-45.
14. Riederer P, Konradi C, Youdim MBH. The role of MAO in dopaminergic transmission. Advances in Neurology 1990; 53: 149-153.
15. Konradi C, Ozelius L, Yan W, Gusella JF, Breakefield XO. Dinucleotid repeat polymorphism (D16S258) on human chromosome 16. Nucleic Acids Research 1991; 19:5449.
16. Konradi C, Ozelius L, Breakefield XO. Highly polymorphic (GT)n repeat sequence in intron II of the human MAOB gene. Genomics 1992; 12:176-177.
17. Konradi C, Kornhuber J, Sofic E, Heckers S, Riederer P, Beckmann H. Variations of monoamines and their metabolites in the human brain putamen. Brain Research 1992; 579:285-290.
18. Girmen AS, Baenziger J, Hotamisligil GS, Konradi C, Shalish C, Sullivan JL, Breakefield XO. Relationship between platelet monoamine oxidase B activity and alleles at the MAOB locus. J Neurochemistry, 1992; 59:2063-2066.
19. Yan W, Boustany R-M, Konradi C, Ozelius L, Trofatter JA, Julier C, Breakefield XO, Gusella JF, Haines JL. Localization of juvenile, but not late infantile, neuronal ceroid lipofuscinosis on chromosome 16. Am J Hum Genetics 1993; 52:89-95.
20. Konradi C, Kobierski LA, Nguyen TV, Heckers S, Hyman SE. The cAMP-response-element-binding protein interacts, but Fos protein does not interact, with the proenkephalin enhancer in rat striatum. Proc Natl Acad Sci USA 1993; 90:7005-7009.
21. Borsook D, Falkowski O, Burstein R, Strassman A, Konradi C, Dauber A, Comb M, Hyman SE. Stress-induced regulation of a human ß-galactosidase fusion gene in the hypothalamus of transgenic mice. Mol Endocrinol, 1994; 8:116-125.
22. Borsook D, Konradi C, Falkowski O, Comb M, Hyman SE. Molecular mechanisms of stress-induced proenkephalin gene-regulation: CREB interacts with the proenkephalin gene in the mouse hypothalamus and is phosphorylated in response to hyperosmolar stress. Mol Enocrinol, 1994; 8:240-248.
23. Konradi C, Cole R, Heckers S, Hyman SE. Amphetamine regulates gene expression in rat striatum via transcription factor CREB. J Neurosci 1994; 14:5623-5634.
24. Cole DG, Kobierski L, Konradi C, Hyman SE. 6-Hydroxydopamine lesions of rat substantia nigra up-regulate dopamine-induced phosphorylation of the cAMP-response element-binding protein in striatal neurons. Proc Natl Acad Sci USA, 1994; 91:9631-9635.
25. Hyman SE, Konradi C, Kobierski L, Cole R, Senatus P. and Green D. Pharmacologic regulation of striatal proenkephalin gene expression via transcription factor CREB. Progress in Clinical and Biological Research 1994, 390: 155-171.
26. Konradi C, Heckers S. Haloperidol induced Fos expression is dependent upon transcription factor CREB and CREB phosphorylation. Neuroscience, 1995; 65:1051-1061.
27. Konradi C, Cole RL, Green D, Senatus P, Leveque J-C, Pollack A, Grossbard SJ, Hyman SE. Analysis of the proenkephalin second messenger-inducible enhancer in rat striatal cultures. J Neurochem 1995; 65:1007-1015.
28. Cole RL, Konradi C, Douglass J, Hyman SE. Neuronal adaptation to amphetamine and dopamine: Molecular mechanisms of prodynorphin gene regulation in rat striatum. Neuron 1995; 14:1-20.
29. Hyman SE, Cole RL, Konradi C, Kosofsky BE. Dopamine regulation of transcription factor-target interaction in rat striatum. Chem Senses, 1995; 20:257-60.
30. Simonian NA, Getz RL, Leveque JC, Konradi C, Coyle JT. Kainic acid induces apoptosis in neurons. Neurosci 1996; 75:1047-55.
31. Konradi C, Leveque JC, Hyman SE. Amphetamine and dopamine-induced immediate early gene expression in striatal neurons depends upon postsynaptic NMDA receptors and calcium. J Neurosci 1996; 16:4231-4239.
32. Lewis SE, Konradi C. Analysis of DNA-protein interactions in the nervous system using the electrophoretic mobility shift assay. Methods 1996; 10:301-11.
33. Li XM, Konradi C, Qi J, Juorio AV, Boulton AA. (-)-Deprenyl down-regulates low afinity NGF receptor (LNGFR) mRNA in PC12 cells. Journal of Neurochemistry, 1996; 66 (Suppl. 2):S11.
34. Rajadhyaksha A, Leveque JC, Macías W, Barczak A, Konradi C. Molecular components of striatal plasticity: The various routes of cyclic AMP pathways. Developmental Neuroscience 1998; 20:204-215.
35. Rajadhyaksha A, Barczak A, Macías W, Leveque J-C, Lewis SE, Konradi C. L-type Ca2+ channels are essential for glutamate-mediated CREB phosphorylation and c-fos gene expression in striatal neurons. J Neurosci 1999; 19:6348-6359.
36. Berger UV, Luthi-Carter R, Passani LA, Elkabes S, Black I, Konradi C, Coyle JT. Glutamate Carboxypeptidase II is expressed by astrocytes in the adult rat nervous system. J Comp Neurol 1999; 415:52-64.
37. Leveque J-C, Macías W, Rajadhyaksha A, Carlson R, Barczak A, Kang S, Li X-M, Coyle JT, Huganir RL, Heckers S, Konradi C. Intracellular modulation of NMDA receptor function by antipsychotic drugs. J. Neurosci 2000; 20(11):4011–4020.
38. Macías W, Carlson R, Rajadhyaksha A, Barczak A, Konradi C. Potassium chloride-depolarization mediates CREB phosphorylation in striatal neurons in an NMDA receptor-dependent manner. Brain Res 2001; 890: 222-232.
39. Konradi C, Heckers S. Antipsychotic drugs and neuroplasticity: Insights into the treatment and neurobiology of schizophrenia; Biol Psych. 2001; 50:729-742.
40. Pliakas A, Carlson RR, Neve RL, Konradi C, Nestler EJ and Carlezon WA Jr. Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated CREB expression in nucleus accumbens; J Neurosci. 2001; 21:7397-7403.
41. Andersson M, Konradi C, Cenci MA. The cyclic AMP response element binding protein is required for dopamine-dependent gene expression in intact but not dopamine-denervated striatal neurons. J Neurosci. 2001; 21:9930–9943.
42. Heckers S, Konradi C. Hippocampal neurons in schizophrenia. J Neural Transmission, J Neural Transm 2002; 109:891-905.
43. Konradi C. and Heckers S. Molecular Aspects of glutamate dysregulation: Implications for schizophrenia and its treatment. Pharmacology and Therapeutics 2003; 97:153-179.
44. Konradi C., Macias W, Dudman JT and Carlson RR. Striatal proenkephalin gene induction: coordinated regulation by cyclic AMP and calcium pathways. Molecular Brain Res. 2003, 115(2):157-61.
45. Chartoff EH, Papadopoulou M, Konradi C. and Carlezon WA Jr. Dopamine-dependent increases in phosphorylation of cAMP response element binding protein (CREB) during precipitated morphine withdrawal in primary cultures of rat striatum. J Neurochem, 2003; 87(1):107-18.
46. Dudman JT, Eaton ME, Rajadhyaksha A, Macias W, Taher M, Barczak A, Kameyama K, Huganir R and Konradi C. Dopamine D1 receptors mediate CREB phosphorylation via phosphorylation of the NMDA receptor at Ser897-NR1. J Neurochem, 2003; 87 (4): 922-34.
47. Chartoff EH. Papadopoulou M. Konradi C. and Carlezon WA Jr. Effects of naloxone-precipitated morphine withdrawal on glutamate-mediated signaling in striatal neurons in vitro. Ann. New York Acad. Sci 2003; 1003:368-71.
48. Konradi C, Eaton ME, MacDonald ML, Walsh J, Benes F and Heckers S. Molecular evidence for mitochondrial dysfunction in bipolar disorder. Arch Gen Psychiatry 2004; 61:300-308.
49. Konradi C, Westin J, Carta M, Eaton ME, Kuter K, Dekundy A, Lundblad M and Cenci MA. Transcriptome analysis in a rat model of L-DOPA-induced dyskinesia, Neurobiol. Dis, 2004, 17(2):219-36.
50. Benes FM, Burke RE, Walsh J, Berretta S, Matzilevich D, Minns M, and Konradi C. Acute amygdalar activation induces an upregulation of multiple monoamine G protein coupled pathways in rat hippocampus. Molecular Psychiatry, 2004, 9(10):932-45, and 895.
51. Eaton ME, Macias W, Youngs RM, Rajadhyaksha A, Dudman JT. and Konradi, C. L-type Ca2+ channel blockers promote Ca2+ influx in dopamine-stimulated striatal neurons. Brain Res Mol Brain Res. 2004, 131 (1-2):65-72
52. Li J, Guo Y, Schroeder FA, Youngs RM, Schmidt TW, Ferris C, Konradi C. and Akbarian S. Dopamine D2-like antagonists induce chromatin remodeling in striatal neurons through cAMP-PKA and NMDA receptor signaling. J Neurochem. 2004 Sep;90(5):1117-31.
53. Carlezon WA Jr. and Konradi C. Understanding the neurobiological consequences of early exposure to psychotropic drugs: linking behavior with molecules. Neuropharmacology. 2004;47 Suppl 1:47-60.
54. MacDonald ML, Eaton ME, Dudman JT and Konradi C. Antipsychotic drugs elevate mRNA levels of presynaptic proteins in the frontal cortex of the rat. Biol. Psychiatry, 2005, 57 (9): 1041-1051.
55. Konradi, C. Gene expression microarray studies in polygenic psychiatric disorders: Applications and data analysis. Brain Res. Rev., 2005.
56. MacDonald ML, Naydenov A, Chu M, Matzilevich D. and Konradi C. Decrease in Creatine Kinase Messenger RNA Expression in the Hippocampus and Dorsolateral Prefrontal Cortex in Bipolar Disorder. Bipolar Diorders, 2005 8:255-64
57. Youngs RM, Chu MS, Meloni EG, Naydenov A, Carlezon WA Jr. and Konradi, C. Lithium administration to preadolescent rats causes long-lasting increases in anxiety-like behavior and has molecular consequences. J Neurosci., 2006, 26:6031-39.
58. Black YD, Maclaren FR, Naydenov A, Carlezon WA Jr., Baxter MG, and Konradi, C. Altered attention and prefrontal cortex gene expression in rats after binge-like exposure to cocaine during adolescence. J Neurosci 2006: 26: 9656-65.
59. Naydenov A, MacDonald ML, Ongur D. and Konradi C. Differences in electron transport gene expression levels between bipolar subjects and normal controls in response to glucose deprivation stress. Arch General Psych, in press.
60. Todtenkopf MS, Parsegian A, Naydenov A, Neve RL, Konradi C, and Carlezon, WA Jr. Brain reward regulated by AMPA receptor subunits in nucleus accumbens shell. J Neurosci, in press
Reviews, Chapters, and Editorials
61. Riederer P, Sofic E, Konradi C. Neurobiochemische Aspekte zur Progression der Parkinsonkrankheit. Post-mortem Befunde und MPTP Modell. In: Fischer PA (ed.) Spätsyndrome der Parkinsonkrankheit. Editiones
62. Konradi C, Riederer P, Jellinger K, Denney R. Zelluläre Wirkung der MAO-Hemmer. In: Riederer P, Przuntek H (eds.) Morbus Parkinson. Springer, 1987, 17-28.
63. Konradi C, Riederer P, Jellinger K, Denney R. Human brain monoamine oxidase: The current status. In: Belmaker RH, Sandler M, Dahlström A (eds.) Progress in catecholamine research, Part C. A. R. Liss, NY 1988.
64. Konradi C, Riederer P, Heinsen H. Histochemistry of MAO subtypes in the brainstem of humans: A relation to the radical hypothesis of Parkinson's disease? In: Przuntek H, Riederer P (eds.) Early diagnosis and preventive therapy in Parkinson's disease. Springer, Vienna, 1989: 243-248.
65. Riederer P, Frölich L, Moll G, Konradi C, Sofic E. Neurobiological findings in senile dementia. In: Maurer K, Wurtman RJ (eds.) Organic brain disorders. Vieweg, 1989.
66. Riederer P, Sofic E, Konradi C, Kornhuber J, Beckmann H, Dietl M, Moll G, Hebenstreit G The role of dopamine in the control of neurobiological functions. In: Flückiger E, Müller EE, Thorner MO (eds.) Basic and clinical aspects of neuroscience. The role of brain dopamine. Springer Berlin,1989.
67. Hyman SE, Cole RL, Konradi C, Kosofsky BE. and Cole D. Dopamine regulation of transcription factor- target interactions in rat striatum: Regulation of proenkephalin, prodynorphin, and c-fos gene expression by transcription factor CREB. In Ariano MA. and Surmeier DJ. (ed.) Molecular and Cellular mechanisms of neostriatal function. R.G. Landes, Austin, Tx, 1995, pp. 129-141.
68. Hyman SE, Cole RL, Schwarzschild M, Cole D, Hope B, Konradi C. Molecular mechanisms of striatal gene regulation: A critical role for glutamate in dopamine-mediated induction. In Merchant K. (ed) Pharmacological regulation of gene expression in the CNS. CRC Boca Raton, Fl, 1996, pp. 115-136.
69. Konradi C. Molecular basis of dopamine and glutamate interactions in the striatum, In D. Goldstein (ed.), Catecholamines: Bridging basic science with clinical medicine, vol. 42. Academic Press, San Diego, 1998, pp. 729-733.
70. Konradi C, Heckers S, Coyle JT. Molecular Biology. In: Nemeroff CB, ed. Textbook of Psychopharmacology. 2nd ed. American Psychiatric Press, Washington, 1998, pp. 37-54.
71. Konradi C, Cepeda C, Levine MS. Dopamine-Glutamate Interactions. In DiChiara G. (Ed.) Handbook of Experimental Pharmacology 154/II: Dopamine in the CNS, Springer, Berlin, 2002, pp 117-133.
72. Heckers S, Konradi C. Anatomic and molecular principles of psychopharmacology. A primer for psychiatrists. Child and Adolescent Psychiatric Clinics of North America 2000; 9:1-22.
73. Konradi, C. Quantification of mRNA in neuronal tissue by Northern Analysis. In Wang, JQ (Ed.) Drugs of abuse: Neurological reviews and protocols, Humana Press, Totowa, New Jersey, 2003, p161-180.
74. Konradi, C. Quantification of protein in brain tissue by Western immunoblot analysis. In Wang, JQ (Ed.) Drugs of abuse: Neurological reviews and protocols, Humana Press, Totowa, New Jersey, 2003, p263-272.
75. Konradi, C. Analysis of DNA-binding activity in neuronal tissue with the electrophoretic mobility-shift assay. In Wang, JQ (Ed.) Drugs of abuse: Neurological reviews and protocols, Humana Press, Totowa, New Jersey, 2003, p315-330.
