The Konradi Lab

Christine Konradi, Ph.D.


1987 Ph.D. University of Vienna, Biology

Postdoctoral Training

Place of Training
Ludwig Boltzmann Institute of Clinical Neurobiology, Lainz Hospital, Vienna
Postdoctoral fellow
Department of Psychiatry
University of Würzburg, Germany
Postdoctoral fellow
Neurology Department, University of
Medicine and Dentistry of New Jersey
Postdoctoral fellow
Massachusetts General Hospital, Harvard
Medical School
Postdoctoral fellow
Molecular Neurobiology
Massachusetts General Hospital, Harvard
Medical School

Academic Appointments

Academic Title
Instructor in Psychiatry
Harvard Medical School
Assistant Professor of Psychiatry
Harvard Medical School
Associate Professor of Psychiatry
Harvard Medical School
Professor of Psychiatry
Vanderbilt University Medical Center
Professor of Pharmacology
Vanderbilt University Medical Center

Research Programs

Years covered Funding source Grant title
1999-2004 NIDA; RO1 Psychostimulant regulation of neural gene expression
2001-2006 NIMH; RO1 Role of Nucleus Accumbens CREB in Depression
2000-2002 NIMH; RO3 Hippocampal Gene expression in schizophrenia
2003-2005 private Mitochondrial function in Bipolar Disorder
2004-2010 NINDS Levodopa dyskinesia and striatal neuroplasticity
2004-2006 NIDA Adolescent drug exposure and adult PFC function
2004-2010 NIMH Hippocampus in Schizophrenia and Bipolar Disorder
2005-2010 NIMH Antipsychotic drug effects in limbic structures
2009-20011 NIMH A model system for abnormalities in electron transport genes in bipolar disorder

Selected Publications

Konradi C, Zimmerman EI, Yang CK, Lohmann KM, Gresch P, Pantazopoulos H, Berretta S, Heckers S. (2011) Hippocampal Interneurons in Bipolar Disorder. Arch Gen Psychiatry, epub ahead of print. http://www.ncbi.nlm.nih.gov/pubmed/21135314

Clay HB, Sillivan S, Konradi C. (2010) Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia. Int J Dev Neurosci. epub ahead of print. www.ncbi.nlm.nih.gov/pubmed/20833242

Naydenov AV, Vassoler F, Luksik AS, Kaczmarska J, Konradi C. (2010) Mitochondrial abnormalities in the putamen in Parkinson's disease dyskinesia. Acta Neuropathol. 120:623-31. www.ncbi.nlm.nih.gov/pubmed/20740286

Cenci MA, Konradi C. (2010) Maladaptive striatal plasticity in L-DOPA-induced dyskinesia. Prog Brain Res. 183:209-33. www.ncbi.nlm.nih.gov/pubmed/20696322

Gregg JR, Herring NR, Naydenov AV, Hanlin RP, Konradi C. (2009) Downregulation of oligodendrocyte transcripts is associated with impaired prefrontal cortex function in rats. Schiz Res. 113:277-87.www.ncbi.nlm.nih.gov/pubmed/19570651

Chartoff EH, Papadopolou M, Macdonald ML, Parsegian A, Potter D, Konradi C, Carlezon WA. (2009) Desipramine reduces stress-activated dynorphin expression and CREB phosphorylation in NAc tissue. Mol Pharmacol. 75(3):704-12.www.ncbi.nlm.nih.gov/pubmed/19106229

Schroeder FA, Penta KL, Matevossian A, Jones SR, Konradi C, Tapper AR, and Akbarian S (2008) Drug-induced activation of dopamine D1 receptor signaling andinhibition of class I/II histone deacetylase induces chromatin remodeling in reward circuitry and modulates cocaine-related behaviors. Neuropsychopharmacology 33(12):2981-92.www.ncbi.nlm.nih.gov/pubmed/18288092

Levine JB, Leeder AD, Parekkadan B, Berdichevsky Y, Rauch SL, Smoller JW, Konradi C, Berthiaume F, Yarmush ML (2008) Isolation rearing impairs wound healing and is associated with increased locomotion and decreased immediate early gene expression in the medial prefrontal cortex of juvenile rats. Neuroscience 151:589-603.www.ncbi.nlm.nih.gov/pubmed/18063315

Naydenov A, MacDonald ML, Ongur D. and Konradi C. (2007) Differences in electron transport gene expression levels between bipolar subjects and normal controls in response to glucose deprivation stress. Archives Gen Psychiatry. 64:555-564.www.ncbi.nlm.nih.gov/pubmed/17485607

Westin, JE, Vercammen L, Strome E, Konradi C, and Cenci MA. (2007) Spatio-temporal pattern of striatal ERK1/2 phosphorylation in a rat model of L-dopa-induced dyskinesia and the role of dopamine D1 receptors. Biol Psych. 62:800-810.www.ncbi.nlm.nih.gov/pubmed/17662258

Levine JB, Youngs RM, MacDonald ML, Chu M, Leeder AD, Berthiaume F, Konradi C (2007) Isolation rearing and hyperlocomotion are associated with reduced immediate early gene expression levels in the medial prefrontal cortex. Neuroscience 145:42-55. www.ncbi.nlm.nih.gov/pubmed/17239545

Black YD, Maclaren FR, Naydenov A, Carlezon WA Jr, Baxter MG, and Konradi C. (2006) Altered attention and prefrontal cortex gene expression in rats after binge-like exposure to cocaine during adolescence. J Neurosci. 26: 9656-65.www.ncbi.nlm.nih.gov/pubmed/16988036

Youngs RM, Chu MS, Meloni EG, Naydenov A, Carlezon WA Jr. and Konradi C. (2006) Lithium administration to preadolescent rats causes long-lasting increases in anxiety-like behavior and has molecular consequences. J Neurosci. 26:6031-39.www.ncbi.nlm.nih.gov/pubmed/16738246

MacDonald ML, Naydenov A, Chu M, Matzilevich D. and Konradi C (2006) Decrease in Creatine Kinase Messenger RNA Expression in the Hippocampus and Dorsolateral Prefrontal Cortex in Bipolar Disorder. Bipolar Diorders 8 (3), 252.www.ncbi.nlm.nih.gov/pubmed/16696827

Todtenkopf MS, Parsegian A, Naydenov A, Neve RL, Konradi C, and Carlezon, WA Jr. (2006) Brain reward regulated by AMPA receptor subunits in nucleus accumbens shell. J Neurosci 26:11665-9.www.ncbi.nlm.nih.gov/pubmed/17093088

Konradi C. (2005) Gene expression microarray studies in polygenic psychiatric disorders: Applications and data analysis. Brain Res. Rev. 50:142-155.www.ncbi.nlm.nih.gov/pubmed/15964635

MacDonald ML, Eaton ME, Dudman JT and Konradi C. (2005) Antipsychotic drugs elevate mRNA levels of presynaptic proteins in the frontal cortex of the rat. Biol. Psychiatry, 57 (9): 1041-1051.www.ncbi.nlm.nih.gov/pubmed/15860345

Carlezon, W.A, Konradi C. (2004) Understanding the neurobiological consequences of early exposure to psychotropic drugs: linking behavior with molecules. Neuropharmacology 47 Suppl 1:47-60.www.ncbi.nlm.nih.gov/pubmed/15464125

Li J, Guo Y, Schroeder FA, Youngs RM, Schmidt TW, Ferris C, Konradi C. and Akbarian S. (2004) Dopamine D2-like antagonists induce chromatin remodeling in striatal neurons through cAMP-PKA and NMDA receptor signaling. J Neurochem. 90 (5):1117-31.www.ncbi.nlm.nih.gov/pubmed/15312167

Konradi C, Westin J, Carta M, Eaton ME, Kuter K, Dekundy A, Lundblad M, Cenci MA. (2004) Transcriptome analysis in a rat model of L-DOPA-induced dyskinesia. Neurobiol Dis. 17 (2):219-36.www.ncbi.nlm.nih.gov/pubmed/15474360

Benes FM, Burke RE, Walsh J, Berretta S, Matzilevich D, Minns M, and Konradi C. (2004) Acute amygdalar activation induces an upregulation of multiple monoamine G protein coupled pathways in rat hippocampus. Molecular Psychiatry, 9(10):932-45, and 895.www.ncbi.nlm.nih.gov/pubmed/15170462

Konradi C, Eaton ME, MacDonald ML, Walsh J, Benes FM and Heckers S. (2004) Molecular evidence for mitochondrial dysfunction in bipolar disorder. Arch Gen Psychiatry 61:300-308.www.ncbi.nlm.nih.gov/pubmed/14993118

Dudman JT, Eaton ME, Rajadhyaksha A, Macias W, Taher M, Barczak A, Kameyama K, Huganir R and Konradi C (2003) Dopamine D1 receptors mediate CREB phosphorylation via phosphorylation of the NMDA receptor at Ser897-NR1. J Neurochem, 87 (4): 922-34.www.ncbi.nlm.nih.gov/pubmed/14622123

Chartoff EH, Papadopoulou M, Konradi C and Carlezon WAJr. (2003) Dopamine-dependent increases in phosphorylation of cAMP response element binding protein (CREB) during precipitated morphine withdrawal in primary cultures of rat striatum. J Neurochem, 87(1):107-18.www.ncbi.nlm.nih.gov/pubmed/12969258

Konradi C. and Heckers S. (2003) Molecular Aspects of glutamate dysregulation: Implications for schizophrenia and its treatment. Pharmacology and Therapeutics, 97:153-179.www.ncbi.nlm.nih.gov/pubmed/12559388

Andersson M, Konradi C. and Cenci M.A. (2001) The cyclic AMP response element binding protein is required for dopamine-dependent gene expression in intact but not dopamine-denervated striatal neurons. J Neurosci, 21:9930-9943.www.ncbi.nlm.nih.gov/pubmed/11739600

Pliakas A, Carlson R.R, Neve R.L, Konradi C, Nestler E.J. and Carlezon W.A. Jr. (2001) Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated CREB expression in nucleus accumbens; J. Neurosci. 21:7397-7403.www.ncbi.nlm.nih.gov/pubmed/11549750

Konradi C. and Heckers S. (2001) Antipsychotic drugs and neuroplasticity: Insights into the treatment and neurobiology of schizophrenia; Biol Psych, 50:729-742.www.ncbi.nlm.nih.gov/pubmed/11720691

Leveque J.-C, Macías W, Rajadhyaksha A, Carlson, R, Barczak, A, Kang S, Li X.-M. Coyle, J.T, Huganir, R.L, Heckers S. and Konradi C. (2000) Intracellular modulation of NMDA receptor function by antipsychotic drugs. J Neurosci 20: 4011–4020.www.ncbi.nlm.nih.gov/pubmed/10818136

Rajadhyaksha A, Barczak A, Macías W, Leveque J.-C, Lewis S.E. and Konradi C. (1999) L-type Ca2+ channels are essential for glutamate-mediated CREB phosphorylation and c-fos gene expression in striatal neurons. J. Neurosci. 19: 6348-6359.www.ncbi.nlm.nih.gov/pubmed/10414964

Konradi C, Leveque J.C. and Hyman S.E. (1996) Amphetamine and dopamine-induced immediate early gene expression in striatal neurons depends upon postsynaptic NMDA receptors and calcium. J. Neurosci. 16:4231-4239.www.ncbi.nlm.nih.gov/pubmed/8753884

Konradi C, Cole R.L, Green D, Senatus P, Leveque J-C, Pollack A, Grossbard S.J. and Hyman S.E. (1995) Analysis of the proenkephalin second messenger-inducible enhancer in rat striatal cultures. J. Neurochem. 65: 1007-1015.www.ncbi.nlm.nih.gov/pubmed/7643080

Cole R.L, Konradi C, Douglass J. and Hyman S.E. (1995) Neuronal adaptation to amphetamine and dopamine: Molecular mechanisms of prodynorphin gene regulation in rat striatum. Neuron 14: 813-823.www.ncbi.nlm.nih.gov/pubmed/7718243

Konradi C. and Heckers S. (1995) Haloperidol-induced Fos expression in striatum is dependent upon transcription factor cyclic AMP response element binding protein. Neuroscience 65: 1051-1061.www.ncbi.nlm.nih.gov/pubmed/7617161

Cole DG, Kobierski L, Konradi C, Hyman SE. (1994) 6-Hydroxydopamine lesions of rat substantia nigra up-regulate dopamine-induced phosphorylation of the cAMP-response element-binding protein in striatal neurons. Proc Natl Acad Sci USA: 91:9631-9635.www.ncbi.nlm.nih.gov/pubmed/7937819

Konradi C, Cole R, Heckers S. and Hyman S.E. (1994) Amphetamine regulates gene expression in rat striatum via transcription factor CREB. J. Neurosci. 14: 5623-5634.www.ncbi.nlm.nih.gov/pubmed/8083758

Konradi C, Kobierski L.A, Nguyen T.V, Heckers S. and Hyman S.E. (1993) The cAMP-response element-binding protein interacts, but Fos protein does not interact, with the proenkephalin enhancer in rat striatum. Proc. Natl. Acad. Sci. USA 90: 7005-7009.www.ncbi.nlm.nih.gov/pubmed/8346209

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