McLaughlin Lab

2013

McLaughlin, B.A. and Gidday, J. Poised for Success: Implementation of Sound Conditioning Strategies to Promote Endogenous Protection in Patients Suffering from Stroke. Translational Stroke Research (Online) 

Grelli, K., Palubinsky, A.M., Kale, A.K., Stankowski, J.N., Lizama, B., Milne, G., Singer, R.J. and McLaughlin, B.A.(Accepted) Alterations of Isocitrate Dehydrogenase Following Acute Ischemic Injury as a Means to Improve Cellular Energetic Status in Neuroadaptation. CNS and Neurological Disorders - Drug Targets

2012

Manibusan and McLaughlin, 2013 in press

2011

Stankowski, J. N., Zeiger, S. L. H., Cohen, E. L., DeFranco, D. B., Cai, J., and McLaughlin, B. A. (2011) C-Terminus of HSC70 interacting protein increases following stroke and impairs survival against acute oxidative stress., Antioxidants and Redox Signaling 14, 1787-1801.

2010 and Previous Years

Musiek, ES, Brooks, JD, Joo, M, Brunoldi, E, Porta, A, Zanoni, G, Vidari, G, Blackwell, TS, Montine, TJ, Milne, GL, McLaughlin, B.A., Morrow, JD. Electrophilic Cyclopentenone Neuroprostanes Are Anti-inflammatory Mediators Formed from the Peroxidation of the {omega}-3 Polyunsaturated Fatty Acid Docosahexaenoic Acid. J Biol Chem, 283(29), 19927-35, 2008.

Kirshner, H. and McLaughlin, B.A. (2008) Wagging the dog- Moving closer to features defined by basic scientists, the protection of prodromal transient ischemic attacks reveals itself.  European Journal of Neurology.  In press 

Altay, T, McLaughlin, B.A., Wu, J.Y., Park, T.S. and Gidday, J. (2007) Slit modulates cerebrovascular inflammation and mediates neuroprotection against global cerebral ischemia.  Experimental Neurology  207 186–194. 

O’Duffy, A.E., Bordelon, Y.M. and McLaughlin, B.A. (2007) Killer proteases and little strokes—how the things that do not kill you make you stronger.  Journal of Cerebral Blood Flow and Metabolism  1-14. 

Musiek, E.M, McLaughlin B.A., and Morrow J.D. (2007) Electrophilic cyclopentenone isoprostanes in neurodegeneration. Journal of Molecular Neuroscience 33:80–86

Milne, G. L., Musiek, E. S., Zanoni, G., Vidari, G., McLaughlin, B., Morrow, J. D.(2006) Development of a novel liquid chromatography-mass spectrometric assay to measure formation of highly reactive cyclopentenone isoprostanes in vivo Clinical Pharmacology & Therapeutics 79, 36. 

Musiek, E.M., Breeding, R.A., Milne G., Morrow, J. and McLaughlin B.A. (2006) Cyclopentenone Isoprostanes Are Novel Bioactive Products Of Lipid Oxidation Which Enhance Neurodegeneration.  Journal of Neurochemistry 97, 1301-1313  

Musiek, E., Milne, G. I., McLaughlin, B. A. & Morrow, J.D. (2005). Cyclopentenone eicosanoids as mediators of neurodegeneration: A pathogenic mechanism of oxidative stress and cyclooxyanese-mediated neurotoxicity. Brain Pathology 15: 149-158.

Milne, G. L., Musiek, E. S., Zanoni, G., Vidari, G., McLaughlin, B., Morrow, J. D. (2005) Development of a high performance liquid chromatography-electrospray ionization tandem mass spectrometric (LC/ESI/MS/MS) assay to quantify highly reactive cyclopentenone eicosanoids in vivo. Free Radical Biology and Medicine 39, 113. 

DiNapoli, M. & McLaughlin B. A. (2005). Role of the ubiquitin proteasome pathway in stroke and transient ischemic attacks - therapeutic opportunities for providing neuroprotection. Current Opinions in Investigational Drugs. 6, 686-699.  

McLaughlin, B. A. (2004). The kinder side of killer proteases: Caspase activation contributes to neuroprotection and CNS remodeling. Apoptosis, 9, 111-121.  

McLaughlin, B. A., Erhardt, J. A., Legos, J. J., White, R., Barone, F. C., Parsons, A. A., & Aizenman, E. (2003). Caspase activation is required for neuroprotection in ischemic preconditioning. Proceedings in the National Academy of Sciences USA, 100, 715-720. 

Du, S., McLaughlin, B. A., Pal, S., & Aizenman, E. (2002). In vitro neurotoxicity of methylisothiazolinone, a commonly used industrial and household biocide, proceeds via a zinc and mitogen-activated protein kinase-dependent pathway. Journal of Neuroscience, 22, 7408-7416.

Legos, J. J., McLaughlin, B. A., Skaper, S. D., Strijbos, P. J. M. L., Herin, G. A., Parsons, A. A., Aizenman, E., Barone, F. C., & Erhardt, J. A. (2002). The selective p38 MAP kinase inhibitor SB239063 protects rat hippocampal and primary cortical neurons from excitotoxic death. European Journal of Pharmacology 447, 37‑42. 

Leszkiewicz, D. N., McLaughlin, B. A., & Aizenman, E. (2002). Protein kinases and light: Unlikely partners in a receptor localization puzzle. Physiology & Behavior, 77, 533-536. 

2001

McLaughlin, B. A., Pal, S., Tran, M. P., Parsons, A. A., Barone, F., Erhardt, J. A., & Aizenman, E. (2001). p38 activation is required upstream of potassium current enhancement and caspase cleavage in oxidant-induced neuronal apoptosis. Journal of Neuroscience, 21, 3303-3311.

Nutall, M. E., Lee D., McLaughlin B. A., Erhardt J. A. (2001) Selective inhibitors of apoptotic caspases: Implications for novel therapeutic approaches. Drug Discovery Today, 6, 85-91. 

McLaughlin, B.A. (2001). Dopamine neurotoxicity and neurodegeneration. In M. F. Chesselet (Ed.), Molecular mechanisms of cell death, pp. 195-231.  Towowa, NJ: Humana Press. 

Aizenman, E., Stout, A. K., Hartnett, K. A., Dineley, K. E., McLaughlin, B. A., & Reynolds, I. J. (2000). Induction of neuronal apoptosis by thiol oxidation: Putative role of intracellular zinc release. Journal of Neurochemistry, 75 (5), 1878-1888. 

Hoyt, K. R., McLaughlin, B.A., Higgins, D. S., Jr., & Reynolds, I. J. (2000). Inhibition of glutamate-induced mitochondrial depolarization by tamoxifen in cultured neurons. Journal of Pharmacology and Experimental Therapeutics, 293(2), 480-486. 

McLaughlin, B. A., & Levitt, P. (1999). Molecular basis of neurological disease. In M. T. T. Wong-Riley (Ed.), Neuroscience secrets, pp. 349-356.  Philadelphia: Hanley & Belfus, Inc.

McLaughlin, B. A., Nelson, D., Erecinska, M., & Chesselet, M. F. (1998). Toxicity of dopamine to striatal neurons in vitro and potentiation of cell death by a mitochondrial inhibitor. Journal of Neurochemistry, 70(6), 2406-2415. 

McLaughlin, B. A., Nelson, D., Silver, I. A., Erecinska, M., & Chesselet, M. F. (1998). Methylmalonate toxicity in primary neuronal cultures. Neuroscience, 86(1), 279-290.

McLaughlin, B. A., Spencer, C., & Eberwine, J. (1996). CAG trinucleotide repeats interact with RNA binding proteins. American Journal of Human Genetics, 59(3), 561-569. 

Robinson, M. B., Hopkins, K., Batshaw, M. L., McLaughlin, B. A., Heyes, M. P., & Oster-Granite, M. L. (1995). Evidence for excitoxicity in the brain of the ornithine carbamoyltransferase deficent sparse for mouse. Developmental Brain Research, 90(1-2), 35-44. 

Eberwine, J. W., & McLaughlin, B. A. (1995). Striatal RNA-binding proteins interact with huntingtin mRNA. In M. A. Ariano & D. J. Surmeier (Eds.), Molecular and cellular mechanisms of neostriatal function, pp. 143-149. 

Batshaw, M. L., Yudkoff, M., McLaughlin, B. A., Gorry, E., Anegawa, N. J. Smith, L. A. S., Hyman, S. L., & Robinson, M. B. (1995). The sparse fur mouse as a model for gene therapy in ornithine carbamoyltransferase deficiency. Gene Therapy, 2, 1-7.