The development of transgenic technology and gene targeting protocols involving homologous recominbation in embryonic stem cells has resulted in numerous mouse lines with specific phenotypes and well-defined DNA structural changes. Candidate genes for diabetes, obesity and other disorders of metabolism have been identified and transgenic mice have been generated using this technology. Moreover, mouse models with metabolic disorders have been created by large-scale mutagenesis. The mission is to advance research in the area of diabetes by providing novel experimental tools to the scientific community for phenotyping mouse transgenic models of diabetes and related disorders.
The Metabolic Pathophysiology, Cardiovascular Pathophysiology and Complications, and Analytical Resources Cores provide novel techniques to better understand mouse models of diabetes and its complications. In addition to these cores, there exists the Animal Health and Welfare Core which performs husbandry and genotyping and the Research and Development program.
One index of success of the NIDDK MMPC program and the Vanderbilt MMPC specifically is the contribution of data produced by the MMPC to publications and oral communications. Please acknowledge the Vanderbilt MMPC when presenting data obtained using Center Services. The MMPC is supported in part by grant U24 DK059637.
Thank you for adherence to this policy.
David H. Wasserman, Ph.D., Director