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Vanderbilt Department of Neurology

Faculty By Divisions


Subramaniam Sriram, M.B., B.S.

William C. Weaver, III, Professor of Experimental Neurology

BIOGRAPHICAL SKETCH

Dr. Sriram earned his B.S. and M.B. from the University of Madras in Madras, India. He served an internship in Medicine at Wayne State University in Detroit, Mich., then a residency in Neurology at Stanford University, where he was Chief Resident from 1978 – 1979. He was a post-doctoral fellow in Neuroimmunology at Stanford, before becoming an acting assistant professor of Neurology in 1981. Sriram remained at Stanford as senior research associate in the Department of Neurology from 1982 to 1984.

In 1984 Sriram joined the faculty at the University of Vermont as assistant professor of Neurology and Cell Biology and became an associate professor in 1989. In 1993 he came to Vanderbilt University as the William Weaver Professor of Experimental Neurology, and continues to hold this position as well as a joint appointment as professor of Microbiology/Immunology.

Currently Sriram is an ad hoc reviewer for multiple journals, as well as associate editor for the Journal of Immunology. He serves on the member board of the National MS Society and is Chairperson for the National MS Society Fellowship Committee.

RESEARCH SUMMARY

The following areas of research are currently being pursued in Dr. Sriram’s laboratory:

a) Using an animal model of LPS mediated demyelination, the laboratory is focusing on the particular neuroimaging characteristics of the demyelinating regions. In addition the research group is exploring novel neuroprotective strategies that will reverse the extent and severity of injury.

b) We are examining the role of the different isoforms of nitric oxide synthase in mediating mitochondrial injury in cultured oligodendrocytes that are cultured with different TLR agonists. We are also examining the role of key enzymes in mitochondrial respiratory chain proteins that mimic hypoxic damage following treatment of oligodendrocytes with LPS.

c) In patients receiving beta Interferon as a treatment for multiple sclerosis, we are examining the role of p53 and p53 down stream protein activation and regulation in lymphocyte populations of peripheral blood mononuclear cells.

d) In collaboration with Dr. Y. Tang and C. Stratton from the department of pathology, we are studying the expression of Chlamydial mRNA in spinal fluid of patients with early MS.

SELECTED PUBLICATIONS

Yao, S., Soutto, M., Sriram, S. Preconditioning with Cobalt chloride or Desferrioxamine Protects Oligodendrocyte Cell Line (MO3.13) from TNF alpha Mediated Cell Death. 2008. J. NeuroScience Res 208. 86:2403-2413.

Yao, S., Soutto, M., Sriram, S. Bacterial Cell Wall Products Increases Stabilization of HIF-1 alpha in an Oligodendrocyte cell line Preconditioned by Cobalt Chloride or Desferrioxamine. J. Neroimmunol. 2008. 30:17-26.

Pawate, S., Agarwal, A Moses, H., and Sriram, S. The Spectrum of Susac's Syndrome. J. Clin Neurology, 2009 Feb, 30(1):59-64.

Tang,Y.W., Sriram, S., Li, H., Yao, S., Meng, W., Mitchell, M., and Stratton, C.W. Qualitative and Quantitative Detection of Chlamydophila pneumoniae DNA in Cerebrospinal Fluid from Multiple Sclerosis Patients and Controls. 2009, 4(4):e5200.

Pawate, S., Moses, H. and Sriram, S. Neurosarcoidosis: Presentations and Outcomes of Neurosarcoidosis: a study of 54 cases. 2009 Jul, 102(7):449-60.

CONTACT INFORMATION

Subramaniam Sriram, M.B., B.S.
William C. Weaver, III, Professor of Experimental Neurology
Professor of Microbiology and Immunology
Neuroimmunology
3810 Bedford Avenue
Suite 100
Nashville, TN 37215
Phone: 615-936-0060
Research: Multiple Sclerosis

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