O'Brien Lab


About the Lab:

The O'Brien Lab is interested in the metabolic function and transcriptional regulation of the glucose-6-phosphatase gene family and especially how these genes contribute to various diseases including diabetes. There are 3 members of this family designated G6PC, G6PC2 and G6PC3. These genes all play a role determining fasting blood glucose levels, a parameter that is correlated with the risk of cardiovascular-associated mortality and type 2 diabetes. But they are also associated with specific diseases namely glycogen storage disease type 1a (G6PC), type 1 diabetes (G6PC2) and neutropenia (G6PC3).

About Richard:

Richard O'Brien received his undergraduate degree from Bristol University, England in 1984 and his doctorate from Cambridge University, England in 1988. Dr. O'Brien then did his post-doctoral training in Dr. Daryl Granner's laboratory at Vanderbilt University, initially as a Research Associate and then as a Research Instructor, before joining the faculty in the Department of Molecular Physiology & Biophysics in 1995 where he now holds the rank of professor.

Contact us:

The O'Brien Lab is located in room 8415 MRB IV.

  • Lab Phone-    615-936-1629
  • Office Phone- 615-936-1503
  • Mailing Address-   Department of Molecular Physiology & Biophysics, 8415 MRB IV, 2213 Garland Avenue, Vanderbilt University School of Medicine, Nashville, TN 37232-0615


  • Post Doctoral positions are availible

This page was last updated August 17, 2010 and is maintained by