Assistant: Christine Goldsberry
Assistant Email: email@example.com
Assistant Phone: 615-936-0277
Education & Training
Research Associate, Physiology/Biophysics, School of Medicine, Wright State University, Dayton, OH (1991)
Research Fellowship, Medicine, Brigham and Women's Hospital, Boston, MA (1991)
PhD, Cell Physiology, University of Liege, Belgium (1989)
MS, Physiology, University of Liege, Belgium (1983)
BS, Biology, University of Liege, Belgium (1981)
Research in my laboratory focuses on the molecular physiology of electroneutral inorganic ion transporters. These transport pathways play major roles in cell volume regulation, epithelial transport, and modulation of synaptic transmission. Inhibitory neurotransmission, for instance, is mediated by g-aminobutyric acid (GABA) and glycine. These two neurotransmitters act principally through ionotropic GABAA and glycine receptors which are associated with Cl- channel activity. The polarity and magnitude of GABA- or glycine-mediated Cl- currents depend upon the level of Cl- in the postsynaptic terminal (postsynaptic neuron). This level is regulated by secondary active transport processes such as K-Cl and Na-K-2Cl cotransporters. These transport mechanisms use the energy of the K+ and/or Na+ gradient, generated by the Na/K-ATPase to drive Cl- away from its electrochemical potential equilibrium. We have shown through the creation of mouse knockouts that these cotransporters are critical in the modulation of inhibitory GABA responses. Absence of these transport mechanisms results in hyperexcitability/ epilepsy as well as pain perception phenotypes. The laboratory uses molecular techniques to study gene promoters, to identify binding/regulatory partners, and to create direct or conditional and/or tissue specific knockouts. The laboratory also uses ion fluxes for structure/function analyses and electrophysiology to assess function of the transporters in synaptic transmission.
The work is supported by NIH grants R01 NS36758, U01 AA13514, and the National Center of the American Heart Association. The laboratory is located in MRB3, rooms 7158/7154.
Aside from research, my other duties at Vanderbilt consist of teaching Medical Physiology lectures on the nervous system, NURO346 lectures for the Neuroscience graduate program; serving on the IACUC committee; serving as a Vanderbilt Discovery Grant reviewer; serving on the Graduation Education Committee of the Department of Molecular Physiology & Biophysics
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