Willam A. Hewlett, M.D., Ph.D.
Associate Professor of Psychiatry & Pharmacology
William.A.Hewlett@vanderbilt.edu
Dr. William Hewlett has been a member of the faculty since 1991. He is Director of the Obsessive Compulsive Disorder (OCD) / Tourette Syndrome Program and is currently involved in full-time basic science research relating to these disorders.
Education
M..D., Stanford University
Ph.D., Stanford University
M.A., Stanford University
B.A., Computer Science & Psychology, University of California, Berkeley
Postgraduate Training
Internship in Psychiatry, Neurology & Medicine, Stanford University
Residency in Adult Psychiatry, Stanford University
Postdoctoral Fellowship in Clinical Neuroscience, Stanford University
Areas of Clinical Expertise
OCD, Trichotillomania, Tourette Syndrome
Research interests
Basic neurochemicaland functional changes in the brain associated with prolonged selective serotonin reuptake inhibitor (SSRI) treatment
Animal models of treatment in OCD
Pharmacologic modulation of the serotonin transport activity
Serotonergic regulation of hormone release in OCD
Phenomenological changes in associated successful treatment of OCD
Representative publications
1. ZhuC-B, Blakely RD, Hewlett WA. (2006) Pro-Inflammatory Cytokines, Interleukin-1 beta and Tumor Necrosis Factor-alpha, Activate Serotonin Transporters. J Neuropsychopharmacolgy. 31(10):2121-31.
2. ZhuC-B, Carneiro AM, Dostmann W, Hewlett WA, and Blakely RD. (2005).p38 MAPK Activation Elevates Serotonin Transport Activity via aTrafficking Independent, PP2A-Dependent Process. J Biol Chem.280(16):15649-15658.
3. Hewlett WA, Schmid SP, and Salomon RM,(2003). Pilot Trial of Ondansetron in the Treatment of Eight Patients with Obsessive Compulsive Disorder (OCD). J. Clin. Psychiatry 64(9),1025-1030.
4. Zhang Z.-J, Schmidt DE, de Paulis T, Trivedi BL,Onaivi ES, Ebert MH and Hewlett WA, (2001). Anxiolytic-like effects ofDAIZAC, a selective high-affinity 5-HT-3 receptor antagonist, in the mouse elevated plus-maze. Pharmacol. Biochem. Behav. 69:1-8.
5. Hewlett WA, Vinogradov S, Berman S, Csernansky JG and Agras WS (1992). Fenfluramine stimulation of prolactin in Obsessive Compulsive Disorder. Psychiatry Research 42:81-92.
