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Type 1 Diabetes TrialNet at Vanderbilt

Type 1 Family Members Screening

Why Screen Family Members for Type 1 Diabetes?
 
Relatives of people with Type 1 diabetes have a 10 to 15 times greater risk for the disease than people with no family history. We don’t yet know the genes that cause diabetes.  However, we can detect antibodies that attack the insulin-producing beta cells months or years before diabetes develops. The goal of the TrialNet Natural History Study is to identify family members who are most at risk and to prevent the process from progressing to diabetes.
 
Who is most at risk to develop Type 1 Diabetes?
 
The closer the blood relationship, the greater one’s risk of developing T1D. For example, identical twins have a higher risk than full siblings.
 
Relative with Diabetes                        Risk of Developing Type 1 DM
Identical Twin                                                       1 in 2
Brother/Sister                                                       1 in 20
No Family History                                                1 in 250
 
What screening studies are available at Vanderbilt?
 
IF YOU
AND
YOU MAY BE ELIGIBLE FOR
Have a mother, father, sister, brother, or child with T1D
Have had your 1st birthday but not yet turned 46
Natural History Study of the Development of T1D
Have a cousin, uncle, aunt, niece, nephew, grandparent, or half-sibling with T1D
Have had your 1st birthday but not yet turned 21
Natural History Study of the Development of T1D
 
What does screening entail?
With a single blood tube drawn from a vein in the arm, four different auto-antibodies can be tested to predict one’s risk of developing T1D.
 
What if I’m not sure if my relative has type 1 or type 2 diabetes?  For the purposes of this study, type 1 diabetes is defined as developing diabetes before age 40 years and starting on insulin injections within a year of diagnosis.
 
What are my options if I/my child is at risk to develop T1D?
There is no proven way to prevent diabetes, but the Oral Insulin Trial aims to test whether ingesting a capsule of insulin by mouth every day will prevent or delay the development of T1D.
 
What are my options if I/my child have already developed T1D?
New Onset Studies are being conducted for those diagnosed within the past three months.
 
If you are interested in participating or would like more information:
Contact
Margo M. Black
615-936-8638 or Toll Free 888-884-8638
diabetesresearch@vanderbilt.edu
  
Please review the pdf brochure and consent forms listed below:
Adult Consent Form - volunteers 18 and over
Parent Consent Form - parents to allow their child to participate
Teen Assent Form - teens 13 to 17
Child Assent Form - children 7 to 12
Screening Form - all participants

This page was last updated May 20, 2013 and is maintained by