Ejaculation occurring within a brief period either before or after vaginal penetration is termed premature ejaculation. Two principal therapeutic options are available for this condition. One is the squeeze technique, a method that is accomplished with the active participation of the partner. Medical treatment is the second method. Medicines called serotonin re-uptake inhibitors have produced striking results in many patients. These medications were initially developed to treat depression. Patients taking the medications reported an increase in time to ejaculation. Several investigators, including us, began to evaluate the effectiveness of the medications for premature ejaculation. A trial of medication usually requires about one month to decide the appropriate dosage and to discover whether an individual will respond to this type of therapy.