Fellowship trainees will study the effect of gene therapy through research
Research is an integral part of the Vascular Fellowship. Trainees are exposed to the basic science research lab with ongoing studies of the effect of gene therapy on arterial remodeling following arterial injury and work regarding CT detection of lower extremity calcification as a predictor of severity of vascular disease. This in-depth exposure to clinical research provides the foundation necessary for fellows to present at a peer review meeting, as well as publish findings in peer reviewed journals.
Ongoing research emphasizes endovascular grafting for aortic aneurysms and peripheral vascular disease. Endovascular grafting was initiated in 1993 and has been rapidly expanding since that time. Additional endovascular grafting projects are underway in this exciting new area in the specialty of Vascular Surgery.
Established in 1985, the Vanderbilt Vascular Laboratory was the first ever to provide a cohesive vascular diagnostic center at Vanderbilt University Medical Center. Hence, the dominant source for inpatient and outpatient vascular testing with ultrasound is accomplished at the Vanderbilt Vascular Laboratory. Accreditation by the Intersocietal Commission for the Accreditation of Vascular Laboratories (ICAVL) is established for cerebrovascular testing as well as venous testing.
Basic science research on enhancement of the patency of vascular bypass grafts has led to the identification of a protein that is felt to be involved with relaxation of smooth muscle associated with vascular bypass grafts and other smooth muscle tissue. These efforts, directed by Dr. Brophy, are funded through NIH and the Veterans Administration and are being expanded through bioengineering collaborative efforts to develop therapeutic agents in the treatment of fibrosis, inflammatory disorders, and epithelial cancers. Dr. Guzman has obtained NIH funding and his efforts focus on understanding the process of arterial calcification which is hoped to lead toward mechanisms to prevent atherogenesis and complicating calcification.