A fundamental question in molecular biology is how human disease is programmed into the genome. The overarching goal of my laboratory is to elucidate the transcription regulatory networks underlying oncogenic signaling pathways. STAT transcription factors in the JAK-STAT pathway (Janus Kinase-Signal Transducer and Activator of Transcription) are among the most frequently activated oncogenic proteins in cancer cells. My current research is focused on discovering how the JAK-STAT pathway is involved in the disease process using genetic, molecular, and next-gen sequencing approaches.
1. Define the STAT regulatory network in a model for human chronic myeloid leukemia using state-of-the-art genomic approaches.
2. Dissect the functional connectivity between the transcription factors in the JAK-STAT signaling pathway.
3. Comparative study investigating how human STATs contribute to oncogenesis in breast, cervical, liver, and hematological cancers.
4. Identify proteins recruited to genomic loci through direct STAT interactions by applying molecular and biochemical techniques.