Faculty and Guest Lecture Series
All lectures take place at noon in Preston Research Building, Room 206
Friday, September 13, 2013
Title of talk: The Wiring Diagram for Hunger and Satiety: Using Cell-Specific Cre/Lox Tools to Discover its Neural Basis
Bradford B. Lowell, MD, PhD
Professor of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center
Research interests: Neurobiological and neurocircuit basis for leptin action and melanocortin-4 receptor action, role of synaptic transmission and NMDAR-mediated synaptic plasticity within feeding circuits, afferent inputs regulating AgRP and POMC neurons, efferent circuits responsible for effects of AgRP and POMC neurons on feeding behavior, dissection of neural pathways regulating sympathetic outflow and energy expenditure, and neural mechanisms by which the brain controls glucose homeostasis.
Friday, October 11, 2013
Title of talk: An integrated view of the role of brain insulin signaling in nutrient partitioning
Christoph Buettner, PhD
Associate Professor, Medicine, Endocrinology, Diabetes and Bone Disease; Associate Professor Neuroscience, Mount Sinai Hospital
Research interests: To understand how hormones and nutrients are sensed by the hypothalamus and how the brain controls systemic metabolism. Hormones like insulin and leptin regulate systemic inflammation via the brain and the autonomic nervous system. We speculate that this may be the basis for the link between impaired metabolic control and inflammation.
Friday, November 8, 2013
Title of talk: Diabetes, Bariatric Surgery and the Gut
J.K.McIvor (1915-1942) Endowed Chair in Diabetes Research; Canada Research Chair in Obesity; Associate Professor, Departments of Physiology and Medicine, University of Toronto; Associate Director, University of Toronto Banting and Best Diabetes Centre; Senior Scientist, Toronto General Hospital Research Institute
Research interests: The long-term goal of my lab is to unveil novel molecules/pathways in the body that regulate both hepatic glucose production and food intake in vivo, and consequently reveal new therapeutic molecules that could be targeted to restore glucose and energy homeostasis in diabetes and obesity.
December 13, 2013
Title of talk: Why does gastric bypass surgery work?
George H. Bray Professor, Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University
Title of talk: Peripheral and Central actions of the metabolic regulator FGF21
Eleftheria Maratos-Flier, MD
Professor of Medicine, Endocrine Division, Beth Israel Deaconess Medical Center
Research interests: The role of CNS in regulating feeding behavior and energy homeostasis with particular focus on hypothalamic-striatal pathways and the role of hormone lepting and the neuropeptide MCH in modulating motivated behavior. My lab initially discovered the orexigenic role of MCH using RT-PCR differential display and we have since followed up on its role by generating over-expressing and knockout mice. We also use mice lacking MCH as a model of anorexia.
Friday, February 14, 2014
James O. Hill, PhD
Executive Director, anschutz Health and Wellness Center, Anschutz Professor of Health and Wellness, Professor of Pediatrics, Medicine, and Physiology & Biophysics, University of Colorado, Anschutz Medical Campus
Research interests: Dr. James Hill is one of America's foremost experts in weight management, researching causes of weight gain, adiposity and obesity. Research includes translating the science of weight management into public health programs like "The Colorado Weigh" and "America on the Move," that promote simple changes in lifestyle that dramatically change body weight and work in the community.
Friday, March 14, 2014
Title of talk: The Neurobiology of Need
Scott M. Sternson, PhD
HHMI Scientist, Janelia Farm Research Campus
Research interests: Reverse engineering the mouse brain in order to understand how neural circuits control innate behaviors. He combines synthetic chemistry with genetics to deliver molecular switches to small groups of neurons in mice. By "flipping" these switches with chemicals or light, he maps neural circuits and measures the contribution of neurons to innate behaviors such as feeding.
Friday, April 11, 2014
Title of talk: Hypothalamic Control of Integrative Physiology of Immunity
Tamas L. Horvath DVM, PhD
Jean and David W. Wallace Professor of Comparative Medicine and Professor of Neurobiology and of Obstetrics, Gynecology, and Reproductive Sciences; Chair, Section of Comparative Medicine; Jean and David W. Wallace Professor of Biomedical Research; Director, Yale Program in Integrative Cell Signaling and Neurobiology of Metabolism
Research interests: Neuroendocrine regulation of homeostasis with particular emphasis on metabolic disorders, such as obesity and diabetes, and the effect of metabolic signals on higher brain functions and neurodegeneration. We have active research programs to pursue the role of snaptic plasticity in the mediation of peripheral hormones' effects on the central nervous system. We also study the role of mitochondrial membrane potential in normal and pathological brain functions with particular emphasis on the acute effect of mitochondria in neuronal transmission and neuroprotection. We combine classical neurobiological approaches, including electrophysiology and neuroanatomy, with endocrine and genetic techniques to better understand biological events at the level of the organism.