Department of Pathology, Microbiology, and Immunology



   James David Chappell, M.D., Ph.D.



Associate Professor
Dept. of Pathology, Microbiology and Immunology

Dept. of Pediatrics
Director, Clinical Diagnostic Virology Laboratory

Director, Molecular Infectious Diseases Laboratory


  Contact Information


Office Location:
   D-7234  MCN

Phone: 615-322-0110

Fax: 615-343-7659

E-mail: jim.chappell@vanderbilt.edu


Campus Mail address:

Pathology, Microbiology and Immunology-3rd Fl

MCN C-3321 (2561)


US Mailing address:

Vanderbilt University School of Medicine

Dept of Pathology, Microbiology and Immunology-3rd Fl

MCN C-3321

Nashville, TN 37232-2561






Fellowship, Vanderbilt
Residency, Vanderbilt
M.D., Vanderbilt
Ph.D., Vanderbilt
M.S., Murray State Univ
B.S., Murray State Univ



Research Keywords





Research Description



Research in our laboratory concentrates on the etiology, epidemiology, prevention, and pathobiology of infectious diseases, with primary emphasis on the respiratory and enteric systems. Current projects in the laboratory include collaborative, multi-center studies of pediatric acute gastroenteritis (AGE) and pediatric and adult acute respiratory illness (ARI) with colleagues in the Departments of Pediatrics and Medicine.

The causes, prevalence, and prevention of pediatric AGE, especially rotavirus- and norovirus-attributable disease, is under investigation through prospective surveillance of ill and asymptomatic children. These efforts are aimed at evaluating ongoing rotavirus vaccine effectiveness and the evolving pathogen spectrum of pediatric AGE in the post-rotavirus vaccine era, information essential to the design of new vaccines and therapies for prevalent gastrointestinal infections.

ARI studies are principally focused on the prevalence, clinical presentation, vaccine-mediated prevention, and treatment of influenza infection. Major goals for this work are to accurately define the burden of influenza disease in hospitalized patients, quantify influenza vaccine effectiveness, and identify opportunities for reducing influenza-related morbidity and mortality through improved applications of vaccines and antiviral therapies. Companion research addresses the prevalence and clinical impact of other common respiratory pathogens, such as respiratory syncytial virus, among individuals hospitalized with ARI.

Other active projects in the laboratory include studies of microbe-host cell interactions, persistence, and antimicrobial susceptibility of the intracellular bacterial pathogen, Chlamydia pneumoniae. This organism is a well-known cause of upper and lower respiratory tract illness with the capacity to establish persistent infection. Research on C. pneumoniae involves characterization of the pathogen life cycle and response to antibiotic treatment using molecular, microscopic, and bacteriologic techniques applied to cell-culture models of infection. Results of these studies will inform understandings of C. pneumoniae persistence strategies in the intact host and guide design of therapeutic regimens that effectively eradicate infection.






Chappell, JD, and TS Dermody. Biology of viruses and viral diseases. In: Bennett, JE, Dolin, R, and MJ Blaser (eds.): Principles and Practice of Infectious Diseases, 8th ed. Elsevier, Philadelphia. pp 1681-1693. , 2015 .

Wolf, RB, Edwards, K, Grijalva, CG, Self, WH, Zhu, Y, Chappell, J, Bramley, AM, Jain, S, Williams, DJ. Time to clinical stability among children hospitalized with pneumonia. J Hosp Med, 10(6), 380-3, 2015

Larkin, EK, Gebretsadik, T, Moore, ML, Anderson, LJ, Dupont, WD, Chappell, JD, Minton, PA, Peebles, RS, Moore, PE, Valet, RS, Arnold, DH, Rosas-Salazar, C, Das, SR, Polack, FP, Hartert, TV, , . Objectives, design and enrollment results from the Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure Study (INSPIRE). BMC Pulm Med, 15, 45, 2015

Jain, S, Williams, DJ, Arnold, SR, Ampofo, K, Bramley, AM, Reed, C, Stockmann, C, Anderson, EJ, Grijalva, CG, Self, WH, Zhu, Y, Patel, A, Hymas, W, Chappell, JD, Kaufman, RA, Kan, JH, Dansie, D, Lenny, N, Hillyard, DR, Haynes, LM, Levine, M, Lindstrom, S, Winchell, JM, Katz, JM, Erdman, D, Schneider, E, Hicks, LA, Wunderink, RG, Edwards, KM, Pavia, AT, McCullers, JA, Finelli, L, , . Community-acquired pneumonia requiring hospitalization among U.S. children. N Engl J Med, 372(9), 835-45, 2015

Foster, MA, Iqbal, J, Zhang, C, McHenry, R, Cleveland, BE, Romero-Herazo, Y, Fonnesbeck, C, Payne, DC, Chappell, JD, Halasa, N, G??mez-Duarte, OG. Enteropathogenic and enteroaggregative E. coli in stools of children with acute gastroenteritis in Davidson County, Tennessee. Diagn Microbiol Infect Dis, 2015

Jain, S, Self, WH, Wunderink, RG, Fakhran, S, Balk, R, Bramley, AM, Reed, C, Grijalva, CG, Anderson, EJ, Courtney, DM, Chappell, JD, Qi, C, Hart, EM, Carroll, F, Trabue, C, Donnelly, HK, Williams, DJ, Zhu, Y, Arnold, SR, Ampofo, K, Waterer, GW, Levine, M, Lindstrom, S, Winchell, JM, Katz, JM, Erdman, D, Schneider, E, Hicks, LA, McCullers, JA, Pavia, AT, Edwards, KM, Finelli, L, , . Community-Acquired Pneumonia Requiring Hospitalization among U.S. Adults. N Engl J Med, 373(5), 415-27, 2015

Self, WH, Williams, DJ, Zhu, Y, Ampofo, K, Pavia, AT, Chappell, JD, Hymas, WC, Stockmann, C, Bramley, AM, Schneider, E, Erdman, D, Finelli, L, Jain, S, Edwards, KM, Grijalva, CG. Respiratory Viral Detection in Children and Adults: Comparing Asymptomatic Controls and Patients With Community-Acquired Pneumonia. J Infect Dis, 2015

Ahn, A, Edwards, KM, Grijalva, CG, Self, WH, Zhu, Y, Chappell, JD, Arnold, SR, McCullers, JA, Ampofo, K, Pavia, AT, Bramley, AM, Jain, S, Williams, DJ. Secondhand Smoke Exposure and Illness Severity among Children Hospitalized with Pneumonia. J Pediatr, 2015

Diaz, MH, Benitez, AJ, Cross, KE, Hicks, LA, Kutty, P, Bramley, AM, Chappell, JD, Hymas, W, Patel, A, Qi, C, Williams, DJ, Arnold, SR, Ampofo, K, Self, WH, Grijalva, CG, Anderson, EJ, McCullers, JA, Pavia, AT, Wunderink, RG, Edwards, KM, Jain, S, Winchell, JM. Molecular Detection and Characterization of Mycoplasma pneumoniae Among Patients Hospitalized With Community-Acquired Pneumonia in the United States. Open Forum Infect Dis, 2(3), ofv106, 2015

Dennis, AF, McDonald, SM, Payne, DC, Mijatovic-Rustempasic, S, Esona, MD, Edwards, KM, Chappell, JD, Patton, JT. Molecular epidemiology of contemporary G2P[4] human rotaviruses cocirculating in a single U.S. community: footprints of a globally transitioning genotype. J Virol, 88(7), 3789-801, 2014

Tang, YW, Lowery, KS, Valsamakis, A, Schaefer, VC, Chappell, JD, White-Abell, J, Quinn, CD, Li, H, Washington, CA, Cromwell, J, Giamanco, CM, Forman, M, Holden, J, Rothman, RE, Parker, ML, Ortenberg, EV, Zhang, L, Lin, YL, Gaydos, CA. Clinical accuracy of a PLEX-ID flu device for simultaneous detection and identification of influenza viruses A and B. J Clin Microbiol, 51(1), 40-5, 2013

Esbenshade, JC, Edwards, KM, Esbenshade, AJ, Rodriguez, VE, Talbot, HK, Joseph, MF, Nwosu, SK, Chappell, JD, Gern, JE, Williams, JV, Talbot, TR. Respiratory virus shedding in a cohort of on-duty healthcare workers undergoing prospective surveillance. Infect Control Hosp Epidemiol, 34(4), 373-8, 2013

Donauer, S, Payne, DC, Edwards, KM, Szilagyi, PG, Hornung, RW, Weinberg, GA, Chappell, J, Hall, CB, Parashar, UD, Staat, MA. Determining the effectiveness of the pentavalent rotavirus vaccine against rotavirus hospitalizations and emergency department visits using two study designs. Vaccine, 2013

Payne, DC, Boom, JA, Staat, MA, Edwards, KM, Szilagyi, PG, Klein, EJ, Selvarangan, R, Azimi, PH, Harrison, C, Moffatt, M, Johnston, SH, Sahni, LC, Baker, CJ, Rench, MA, Donauer, S, McNeal, M, Chappell, J, Weinberg, GA, Tasslimi, A, Tate, JE, Wikswo, M, Curns, AT, Sulemana, I, Mijatovic-Rustempasic, S, Esona, MD, Bowen, MD, Gentsch, JR, Parashar, UD. Effectiveness of Pentavalent and Monovalent Rotavirus Vaccines in Concurrent Use Among US Children <5 Years of Age, 2009-2011. Clin Infect Dis, 2013

Payne, DC, Vinj??, J, Szilagyi, PG, Edwards, KM, Staat, MA, Weinberg, GA, Hall, CB, Chappell, J, Bernstein, DI, Curns, AT, Wikswo, M, Shirley, SH, Hall, AJ, Lopman, B, Parashar, UD. Norovirus and medically attended gastroenteritis in U.S. children. N Engl J Med, 368(12), 1121-30, 2013

Tate, JE, Mijatovic-Rustempasic, S, Tam, KI, Lyde, FC, Payne, DC, Szilagyi, P, Edwards, K, Staat, MA, Weinberg, GA, Hall, CB, Chappell, J, McNeal, M, Gentsch, JR, Bowen, MD, Parashar, UD. Comparison of 2 assays for diagnosing rotavirus and evaluating vaccine effectiveness in children with gastroenteritis. Emerg Infect Dis, 19(8), 1245-52, 2013

Self, WH, McNaughton, CD, Grijalva, CG, Zhu, Y, Chappell, JD, Williams, JV, Talbot, HK, Shay, DK, Griffin, MR. Diagnostic performance of the BinaxNow Influenza A&B rapid antigen test in ED patients. Am J Emerg Med, 30(9), 1955-61, 2012

McDonald, SM, McKell, AO, Rippinger, CM, McAllen, JK, Akopov, A, Kirkness, EF, Payne, DC, Edwards, KM, Chappell, JD, Patton, JT. Diversity and relationships of cocirculating modern human rotaviruses revealed using large-scale comparative genomics. J Virol, 86(17), 9148-62, 2012

McClain, CM, Stratton, CW, Chappell, JD, Van Horn, GT. Coccidioides, Cryptococcus, or Blastomyces? A Diagnostic Dilemma Encountered During Frozen Section Evaluation. Pediatr Dev Pathol, 2011

Payne, DC, Staat, MA, Edwards, KM, Szilagyi, PG, Weinberg, GA, Hall, CB, Chappell, J, Curns, AT, Wikswo, M, Tate, JE, Lopman, BA, Parashar, UD, , . Direct and indirect effects of rotavirus vaccination upon childhood hospitalizations in 3 US Counties, 2006-2009. Clin Infect Dis, 53(3), 245-53, 2011

Monsalvo, AC, Batalle, JP, Lopez, MF, Krause, JC, Klemenc, J, Hernandez, JZ, Maskin, B, Bugna, J, Rubinstein, C, Aguilar, L, Dalurzo, L, Libster, R, Savy, V, Baumeister, E, Aguilar, L, Cabral, G, Font, J, Solari, L, Weller, KP, Johnson, J, Echavarria, M, Edwards, KM, Chappell, JD, Crowe, JE, Williams, JV, Melendi, GA, Polack, FP. Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes. Nat Med, 17(2), 195-9, 2011

O''Leary, MF, Chappell, JD, Stratton, CW, Cronin, RM, Taylor, MB, Tang, YW. Complex febrile seizures followed by complete recovery in an infant with high-titer 2009 pandemic influenza A (H1N1) virus infection. J Clin Microbiol, 48(10), 3803-5, 2010

Libster, R, Bugna, J, Coviello, S, Hijano, DR, Dunaiewsky, M, Reynoso, N, Cavalieri, ML, Guglielmo, MC, Areso, MS, Gilligan, T, Santucho, F, Cabral, G, Gregorio, GL, Moreno, R, Lutz, MI, Panigasi, AL, Saligari, L, Caballero, MT, Eg??es Almeida, RM, Gutierrez Meyer, ME, Neder, MD, Davenport, MC, Del Valle, MP, Santidrian, VS, Mosca, G, Garcia Dom?-nguez, M, Alvarez, L, Landa, P, Pota, A, Bolo??ati, N, Dalamon, R, Sanchez Mercol, VI, Espinoza, M, Peuchot, JC, Karolinski, A, Bruno, M, Borsa, A, Ferrero, F, Bonina, A, Ramonet, M, Albano, LC, Luedicke, N, Alterman, E, Savy, V, Baumeister, E, Chappell, JD, Edwards, KM, Melendi, GA, Polack, FP. Pediatric hospitalizations associated with 2009 pandemic influenza A (H1N1) in Argentina. N Engl J Med, 362(1), 45-55, 2010

Dulek, DE, Williams, JV, Creech, CB, Schulert, AK, Frangoul, HA, Domm, J, Denison, MR, Chappell, JD. Use of intravenous zanamivir after development of oseltamivir resistance in a critically Ill immunosuppressed child infected with 2009 pandemic influenza A (H1N1) virus. Clin Infect Dis, 50(11), 1493-6, 2010

Chappell, JD, and TS Dermody. Introduction to viruses and viral diseases. In: Mandell, GL, Bennett, JE, and R. Dolin (eds.): Principles and Practice of Infectious Diseases, 7th ed. Elsevier, Philadelphia. pp 1907-1921., 2009

Sato, M, Li, H, Ikizler, MR, Werkhaven, JA, Williams, JV, Chappell, JD, Tang, YW, Wright, PF. Detection of viruses in human adenoid tissues using multiplex-PCR. J Clin Microbiol, 47, 771-773, 2009

Gray, GC, McCarthy, T, Lebeck, MG, Schnurr, DP, Russell, KL, Kajon, AE, Landry, ML, Leland, DS, Storch, GA, Ginocchio, CC, Robinson, CC, Demmler, GJ, Saubolle, MA, Kehl, SC, Selvarangan, R, Miller, MB, Chappell, JD, Zerr, DM, Kiska, DL, Halstead, DC, Capuano, AW, Setterquist, SF, Chorazy, ML, Dawson, JD, Erdman, DD. Genotype prevalence and risk factors for severe clinical adenovirus infection, United States 2004-2006. Clin Infect Dis, 45(9), 1120-31, 2007

Li, H, McCormac, MA, Estes, WR, Sefers, SE, Dare, RK, Chappell, JD, Erdman, DD, Wright, PF, Tang, YW. Simultaneous detection and high-throughput identification of a panel of RNA viruses causing respiratory tract infections. Journal of Clinical Microbiology, 45, 2105-2109, 2007