.

Department of Pathology, Microbiology, and Immunology

 

 

  S. Kent Dickeson, Ph.D.

 

 

Research Assistant Professor

Dept. of Pathology, Microbiology and Immunology

 

 

 Contact Information

 

 

Office Location:

522B PRB

Phone: 615-936-1798

E-mail: stephen.k.dickeson@vanderbilt.edu 

 

Campus Mail address:

Pathology, Microbiology and Immunology-3rd Fl

C-3321 MCN (2561)

 

US Mailing address:

Pathology, Microbiology and Immunology-3rd Fl

Vanderbilt University School of Medicine

C-3321 MCN

Nashville, TN 37232-2561

 

 

 

Education

 

 

Ph.D., Kansas Univ Med Ctr
B.S., Southwest Missouri State Univ

 

 

Research Keywords

 

 

coagulation, Factor XI, collagen, platelet, integrin, I domain, extracellular matrix, cell adhesion, aggregation, MIDAS, collectin

 

 

Research Description

 

 

Investigating the role of Factor XI in coagulation and thrombosis.

 

 

Publications

 

 

Tran, T, Barlow, B, O''Rear, L, Jarvis, B, Li, Z, Dickeson, K, Dupont, W, Zutter, M. Loss of the I?2I?1 integrin alters human papilloma virus-induced squamous carcinoma progression in vivo and in vitro. PLoS One, 6(10), e26858, 2011

Wright, S, Parham, C, Lee, B, Clarke, D, Auckland, L, Johnston, J, Lawrence, AL, Dickeson, SK, Santoro, SA, Griswold-Prenner, I, Bix, G. Perlecan domain V inhibits I?2 integrin-mediated amyloid-I? neurotoxicity. Neurobiol Aging, 2010

Zou, Z, Schmaier, AA, Cheng, L, Mericko, P, Dickeson, SK, Stricker, TP, Santoro, SA, Kahn, ML. Negative regulation of activated alpha-2 integrins during thrombopoiesis. Blood, 113(25), 6428-39, 2009

Marjoram, RJ, Voss, B, Pan, Y, Dickeson, SK, Zutter, MM, Hamm, HE, Santoro, SA. Suboptimal activation of protease-activated receptors enhances alpha2beta1 integrin-mediated platelet adhesion to collagen. J Biol Chem, 284(50), 34640-7, 2009

Maginnis, MS, Forrest, JC, Kopecky-Bromberg, SA, Dickeson, SK, Santoro, SA, Zutter, MM, Nemerow, GR, Bergelson, JM, Dermody, TS. Beta1 integrin mediates internalization of mammalian reovirus. J Virol, 80(6), 2760-70, 2006

Edelson, BT, Stricker, TP, Li, Z, Dickeson, SK, Shepherd, VL, Santoro, SA, Zutter, MM. Novel collectin/C1q receptor mediates mast cell activation and innate immunity. Blood, 107(1), 143-50, 2006

Stricker, T P, Dumin, J A, Dickeson, S K, Chung, L, Nagase, H, Parks, W C, Santoro, S A. Structural analysis of the alpha(2) integrin I domain/procollagenase-1 (matrix metalloproteinase-1) interaction.. J Biol Chem, 276(31), 29375-81, 2001

Ohman, T, King, S L, Krithivas, A, Cunningham, J, Dickeson, S K, Santoro, S A, Bergelson, J M. Echoviruses 1 and 8 are closely related genetically, and bind to similar determinants within the VLA-2 I domain.. Virus Res, 76(1), 1-8, 2001

Dumin, J A, Dickeson, S K, Stricker, T P, Bhattacharyya-Pakrasi, M, Roby, J D, Santoro, S A, Parks, W C. Pro-collagenase-1 (matrix metalloproteinase-1) binds the alpha(2)beta(1) integrin upon release from keratinocytes migrating on type I collagen.. J Biol Chem, 276(31), 29368-74, 2001

Ding, Q, Gladson, C L, Guidry, C R, Santoro, S A, Dickeson, S K, Shin, J T, Thompson, J A. Extracellular FGF-1 inhibits cytoskeletal organization and promotes fibroblast motility.. Growth Factors, 18(2), 93-107, 2000

Dickeson, S K, Mathis, N L, Rahman, M, Bergelson, J M, Santoro, S A. Determinants of ligand binding specificity of the alpha(1)beta(1) and alpha(2)beta(1) integrins.. J Biol Chem, 274(45), 32182-91, 1999

Zutter, M M, Santoro, S A, Wu, J E, Wakatsuki, T, Dickeson, S K, Elson, E L. Collagen receptor control of epithelial morphogenesis and cell cycle progression.. Am J Pathol, 155(3), 927-40, 1999

Dickeson, S K, Walsh, J J, Santoro, S A. Binding of the alpha 2 integrin I domain to extracellular matrix ligands: structural and mechanistic differences between collagen and laminin binding.. Cell Adhes Commun, 5(4), 273-81, 1998

Dickeson, S K, Bhattacharyya-Pakrasi, M, Mathis, N L, Schlesinger, P H, Santoro, S A. Ligand binding results in divalent cation displacement from the alpha 2 beta 1 integrin I domain: evidence from terbium luminescence spectroscopy.. Biochemistry, 37(32), 11280-8, 1998

Dickeson, S K, Santoro, S A. Ligand recognition by the I domain-containing integrins.. Cell Mol Life Sci, 54(6), 556-66, 1998

Bhattacharyya-Pakrasi, M, Dickeson, S K, Santoro, S A. Alpha2beta1 integrin recognition of the carboxyl-terminal propeptide of type I procollagen: integrin recognition and feed-back regulation of matrix biosynthesis are mediated by distinct sequences.. Matrix Biol, 17(3), 223-32, 1998

Dickeson, S K, Walsh, J J, Santoro, S A. Contributions of the I and EF hand domains to the divalent cation-dependent collagen binding activity of the alpha2beta1 integrin.. J Biol Chem, 272(12), 7661-8, 1997

Dickeson, S K, Helmkamp, G M, Yarbrough, L R. Sequence of a human cDNA encoding phosphatidylinositol transfer protein and occurrence of a related sequence in widely divergent eukaryotes.. Gene, 142(2), 301-5, 1994

Dickeson, S K, Lim, C N, Schuyler, G T, Dalton, T P, Helmkamp, G M, Yarbrough, L R. Isolation and sequence of cDNA clones encoding rat phosphatidylinositol transfer protein.. J Biol Chem, 264(28), 16557-64, 1989