Department of Pathology, Microbiology, and Immunology

 

 

  Maralie G. Exton, B.A.

 

 

Laboratory Manager/Program Director

Dept. of Pathology, Microbiology and Immunology  

 

 

 Contact Information

 

 

Office Location:

4605 TVC

  Nashville , TN 37232-5310

Phone: 615-322-6940

E-mail: maralie.exton@vanderbilt.edu

 

Campus Mail address:

Pathology Labs/Blood Bank

4605 TVC (5310)

 

US Mailing address:

Dept of Pathology, Microbiology and Immunology

Vanderbilt University School of Medicine

4605 TVC

Nashville, TN 37232-5310

 

 

Education

 

 

B.A., Randolph-Macon Woman's

 

 

Research Keywords

 

 

 

 

Research Description

 

 

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Publications

 

 

Exton, JH. In search of the message. J Biol Chem, 283(22), 14901-9, 2008

Brown, HA, Henage, LG, Preininger, AM, Xiang, Y, Exton, JH. Biochemical analysis of phospholipase D. Methods Enzymol, 434, 49-87, 2007

Henage, LG, Exton, JH, Brown, HA. Kinetic analysis of a mammalian phospholipase D: allosteric modulation by monomeric GTPases, protein kinase C, and polyphosphoinositides. J Biol Chem, 281(6), 3408-17, 2006

Hu, P, Han, Z, Couvillon, AD, Kaufman, RJ, Exton, JH. Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression. Mol Cell Biol, 26(8), 3071-84, 2006

Couvillon, AD, Exton, JH. Role of heterotrimeric G-proteins in lysophosphatidic acid-mediated neurite retraction by RhoA-dependent and -independent mechanisms in N1E-115 cells. Cell Signal, 18(5), 715-28, 2006

Hiroyama, M, Exton, JH. Localization and regulation of phospholipase D2 by ARF6. J Cell Biochem, 95(1), 149-64, 2005

Kook, S, Exton, JH. Identification of interaction sites of protein kinase Calpha on phospholipase D1. Cell Signal, 17(11), 1423-32, 2005

Hu, T, Exton, JH. A point mutation at phenylalanine 663 abolishes protein kinase C alpha''s ability to translocate to the perinuclear region and activate phospholipase D1. Biochem Biophys Res Commun, 333(3), 750-3, 2005

Chen, JS, Exton, JH. Sites on phospholipase D2 phosphorylated by PKCalpha. Biochem Biophys Res Commun, 333(4), 1322-6, 2005

Ho, WT, Xie, Z, Zhao, ZJ, Exton, JH. Tyrosine phosphorylation of phospholipase D1 by v-Src does not per se result in activation. Cell Signal, 17(6), 691-9, 2005

Hiroyama, M, Exton, JH. Studies of the roles of ADP-ribosylation factors and phospholipase D in phorbol ester-induced membrane ruffling. J Cell Physiol, 202(2), 608-22, 2005

Hu, T, Exton, JH. 1-Butanol interferes with phospholipase D1 and protein kinase Calpha association and inhibits phospholipase D1 basal activity. Biochem Biophys Res Commun, 327(4), 1047-51, 2005

Buchanan, FG, McReynolds, M, Couvillon, A, Kam, Y, Holla, VR, Dubois, RN, Exton, JH. Requirement of phospholipase D1 activity in H-RasV12-induced transformation. Proc Natl Acad Sci U S A, 102(5), 1638-42, 2005

Hu, T, Exton, JH. Protein kinase Calpha translocates to the perinuclear region to activate phospholipase D1. J Biol Chem, 279(34), 35702-8, 2004

Chen, JS, Exton, JH. Regulation of phospholipase D2 activity by protein kinase C alpha. J Biol Chem, 279(21), 22076-83, 2004

Kam, Y, Exton, JH. Role of phospholipase D1 in the regulation of mTOR activity by lysophosphatidic acid. FASEB J, 18(2), 311-9, 2004

Kam, Y, Exton, JH. Role of phospholipase D in the activation of protein kinase D by lysophosphatidic acid. Biochem Biophys Res Commun, 315(1), 139-43, 2004

Hu, T, Exton, JH. Mechanisms of regulation of phospholipase D1 by protein kinase Calpha. J Biol Chem, 278(4), 2348-55, 2003

Ho, WT, Exton, JH, Williger, BT. Arfaptin 1 inhibits ADP-ribosylation factor-dependent matrix metalloproteinase-9 secretion induced by phorbol ester in HT 1080 fibrosarcoma cells. FEBS Lett, 537(1-3), 91-5, 2003

Exton, JH. Regulation of phospholipase D. FEBS Lett, 531(1), 58-61, 2002