Department of Pathology, Microbiology, and Immunology



  David R. Head, M.D.




Dept. of Pathology, Microbiology and Immunology



  Contact Information



Office Location:

4800B TVC

Nashville, TN 37232-5310

Phone: 615.343.9049

Fax: 615.343.7961

E-mail: david.head@vanderbilt.eduVanderbilt


Campus Mail address:

Pathology Labs/Blood Bank

4601 TVC (5310)


US Mailing address:

Pathology Labs/Blood Bank

Vanderbilt University School of Medicine

4601 TVC

Nashville, TN 37232-5310







M.D., Univ of TX
B.A., Rice Univ



Research Keywords



Leukemia; Myelodysplastic Syndrome; Crosslink DNA Damage



Research Description



Half of clinical acute myeloid leukemia (AML) is preceded by or similar to Myelodysplastic Syndrome (MDS)(also known as preleukemia). This set of diseases is refractory to current treatment except stem cell transplantation (SCT). Because of its age distribution (elderly), most patients are ineligible for SCT. The pathogenesis of these diseases is unknown, but some data suggest a relationship to interstrand crosslink (ICL) DNA damage. The repair system for correcting such damage is largely unknown. We are evaluating genes upregulated in response to ICL damage as genes possiblly relevant to the pathogenesis of MDS and AML.



Clinical Research Description



Half of Acute Myeloid Leukemia (AML) cases follow or are biologically related to Myelodysplastic Syndrome (MDS)(also known as preleukemia). The pathogenesis of this set of diseases is unknown, and easily applicable tools to separate these cases from the remainder of AM do not exist. This is important, since treatment difrfers substantially for the two broad groups of AML, MDS-related (MDR-) versus De Novo AML. Interstrand crosslink (ICL) DNA damage is implicated in the pathogenesis of at least some cases of MDS and MDR-AML. Using gene expression, protein microarray, and flow cytometric analysis we are evaluating the cellular response to ICL crosslink DNA damage. Using similar tools we are also evaluating biologic characteristics of bone marrow samples from patients with MDS.






McClintock-Treep, SA, Briggs, RC, Shults, KE, Flye-Blakemore, LA, Mosse, CA, Jagasia, MH, Shinar, AA, Dupont, WD, Stelzer, GT, Head, DR. Quantitative assessment of myeloid nuclear differentiation antigen distinguishes myelodysplastic syndrome from normal bone marrow. Am J Clin Pathol, 135(3), 380-5, 2011

Head, DR, Jacobberger, JW, Mosse, C, Jagasia, M, Dupont, W, Goodman, S, Flye, L, Shinar, A, McClintock-Treep, S, Stelzer, G, Briggs, R, Shults, K. Innovative analyses support a role for DNA damage and an aberrant cell cycle in myelodysplastic syndrome pathogenesis. Bone Marrow Res, 2011, 950934, 2011

Greenberg, PL, Attar, E, Bennett, JM, Bloomfield, CD, De Castro, CM, Deeg, HJ, Foran, JM, Gaensler, K, Garcia-Manero, G, Gore, SD, Head, D, Komrokji, R, Maness, LJ, Millenson, M, Nimer, SD, O''Donnell, MR, Schroeder, MA, Shami, PJ, Stone, RM, Thompson, JE, Westervelt, P, , . NCCN Clinical Practice Guidelines in Oncology: myelodysplastic syndromes. J Natl Compr Canc Netw, 9(1), 30-56, 2011

Qualtieri, J, Stratton, CW, Head, DR, Tang, YW. PCR detection of Histoplasma capsulatum var. capsulatum in whole blood of a renal transplant patient with disseminated histoplasmosis. Ann Clin Lab Sci, 39(4), 409-12, 2009

Petersdorf, SH, Rankin, C, Head, DR, Terebelo, HR, Willman, CL, Balcerzak, SP, Karnad, AB, Dakhil, SR, Appelbaum, FR. Phase II evaluation of an intensified induction therapy with standard daunomycin and cytarabine followed by high dose cytarabine for adults with previously untreated acute myeloid leukemia: a Southwest Oncology Group study (SWOG-9500). Am J Hematol, 82(12), 1056-62, 2007

Appelbaum, FR, Gundacker, H, Head, DR, Slovak, ML, Willman, CL, Godwin, JE, Anderson, JE, Petersdorf, SH. Age and acute myeloid leukemia. Blood, 107(9), 3481-5, 2006

Becton, D, Dahl, GV, Ravindranath, Y, Chang, MN, Behm, FG, Raimondi, SC, Head, DR, Stine, KC, Lacayo, NJ, Sikic, BI, Arceci, RJ, Weinstein, H, , . Randomized use of cyclosporin A (CsA) to modulate P-glycoprotein in children with AML in remission: Pediatric Oncology Group Study 9421. Blood, 107(4), 1315-24, 2006

Briggs, RC, Shults, KE, Flye, LA, McClintock-Treep, SA, Jagasia, MH, Goodman, SA, Boulos, FI, Jacobberger, JW, Stelzer, GT, Head, DR. Dysregulated human myeloid nuclear differentiation antigen expression in myelodysplastic syndromes: evidence for a role in apoptosis. Cancer Res, 66(9), 4645-51, 2006

Hussein, MA, Gundacker, H, Head, DR, Elias, L, Foon, KA, Boldt, DH, Dobin, SM, Dakhil, SR, Budd, GT, Appelbaum, FR. Cyclophosphamide followed by fludarabine for untreated chronic lymphocytic leukemia: a phase II SWOG TRIAL 9706. Leukemia, 19(11), 1880-6, 2005

Jiang, F, Shults, K, Flye, L, Hashimoto, Y, Van Der Meer, R, Xie, J, Kravtsov, V, Price, J, Head, DR, Briggs, RC. S100P is selectively upregulated in tumor cell lines challenged with DNA cross-linking agents. Leuk Res, 29(10), 1181-90, 2005

Xie, J, Shults, K, Flye, L, Jiang, F, Head, DR, Briggs, RC. Overexpression of GSTA2 protects against cell cycle arrest and apoptosis induced by the DNA inter-strand crosslinking nitrogen mustard, mechlorethamine. J Cell Biochem, 95(2), 339-51, 2005

Shankar, S, Choi, JK, Dermody, TS, Head, DR, Bunin, N, Iannone, R. Pulmonary hypertension complicating bone marrow transplantation for idiopathic myelofibrosis. J Pediatr Hematol Oncol, 26(6), 393-7, 2004

Cheson, BD, Bennett, JM, Kopecky, KJ, B??chner, T, Willman, CL, Estey, EH, Schiffer, CA, Doehner, H, Tallman, MS, Lister, TA, Lo-Coco, F, Willemze, R, Biondi, A, Hiddemann, W, Larson, RA, L??wenberg, B, Sanz, MA, Head, DR, Ohno, R, Bloomfield, CD, LoCocco, F, , . Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia. J Clin Oncol, 21(24), 4642-9, 2003

Hasle, H, Niemeyer, C M, Chessells, J M, Baumann, I, Bennett, J M, Kerndrup, G, Head, D R, . A pediatric approach to the WHO classification of myelodysplastic and myeloproliferative diseases.. Leukemia, 17, 277-82, 2003

Hinds, Pamela S, Quargnenti, Alice, Gattuso, Jami, Kumar Srivastova, Deo, Tong, Xin, Penn, Linda, West, Nancy, Cathey, Patricia, Hawkins, Darlene, Wilimas, Judith, Starr, Matthew, Head, David. Comparing the results of coagulation tests on blood drawn by venipuncture and through heparinized tunneled venous access devices in pediatric patients with cancer. Oncol Nurs Forum, 29(3), E26-34, 2002

Anderson, Jeanne E, Kopecky, Kenneth J, Willman, Cheryl L, Head, David, O'Donnell, Margaret R, Luthardt, Frederick W, Norwood, Thomas H, Chen, I-Ming, Balcerzak, Stanley P, Johnson, David B, Appelbaum, Frederick R, . Outcome after induction chemotherapy for older patients with acute myeloid leukemia is not improved with mitoxantrone and etoposide compared to cytarabine and daunorubicin: a Southwest Oncology Group study.. Blood, 100, 3869-76, 2002

Sandlund, John T, Harrison, Patricia L, Rivera, Gaston, Behm, Frederick G, Head, David, Boyett, James, Rubnitz, Jeffrey E, Gajjar, Amar, Raimondi, Susana, Ribeiro, Raul, Hudson, Melissa, Relling, Mary, Evans, William, Pui, Ching-Hon. Persistence of lymphoblasts in bone marrow on day 15 and days 22 to 25 of remission induction predicts a dismal treatment outcome in children with acute lymphoblastic leukemia. Blood, 100(1), 43-7, 2002

List, Alan F, Kopecky, Kenneth J, Willman, Cheryl L, Head, David R, Slovak, Marilyn L, Douer, Dan, Dakhil, Shaker R, Appelbaum, Frederick R, . Cyclosporine inhibition of P-glycoprotein in chronic myeloid leukemia blast phase.. Blood, 100, 1910-2, 2002

Bloomfield, Clara D, Archer, Kellie J, Mr??zek, Krzysztof, Lillington, Debra M, Kaneko, Yasuhiko, Head, David R, Dal Cin, Paola, Raimondi, Susana C. 11q23 balanced chromosome aberrations in treatment-related myelodysplastic syndromes and acute leukemia: report from an international workshop. Genes Chromosomes Cancer, 33(4), 362-78, 2002

Doggett, Kevin L, Briggs, Judith A, Linton, MacRae F, Fazio, Sergio, Head, David R, Xie, Jingping, Hashimoto, Yuko, Laborda, Jorge, Briggs, Robert C, . Retroviral mediated expression of the human myeloid nuclear antigen in a null cell line upregulates Dlk1 expression.. J Cell Biochem, 86, 56-66, 2002

Head, David R. Proposed changes in the definitions of acute myeloid leukemia and myelodysplastic syndrome: are they helpful. Curr Opin Oncol, 14(1), 19-23, 2002

Krance, R A, Hurwitz, C A, Head, D R, Raimondi, S C, Behm, F G, Crews, K R, Srivastava, D K, Mahmoud, H, Roberts, W M, Tong, X, Blakley, R L, Ribeiro, R C. Experience with 2-chlorodeoxyadenosine in previously untreated children with newly diagnosed acute myeloid leukemia and myelodysplastic diseases. J Clin Oncol, 19(11), 2804-11, 2001

Petersdorf, S H, Kopecky, K J, Head, D R, Boldt, D H, Balcerzak, S P, Wun, T, Roy, V, Veith, R W, Appelbaum, F R. Comparison of the L10M consolidation regimen to an alternative regimen including escalating methotrexate/L-asparaginase for adult acute lymphoblastic leukemia: a Southwest Oncology Group Study. Leukemia, 15(2), 208-16, 2001

Athale, U H, Razzouk, B I, Raimondi, S C, Tong, X, Behm, F G, Head, D R, Srivastava, D K, Rubnitz, J E, Bowman, L, Pui, C H, Ribeiro, R C. Biology and outcome of childhood acute megakaryoblastic leukemia: a single institution's experience. Blood, 97(12), 3727-32, 2001

McNall, R Y, Head, D R, Pui, C H, Razzouk, B I. Parvovirus B19 infection in a child with acute lymphoblastic leukemia during induction therapy. J Pediatr Hematol Oncol, 23(5), 309-11, 2001

List, A F, Kopecky, K J, Willman, C L, Head, D R, Persons, D L, Slovak, M L, Dorr, R, Karanes, C, Hynes, H E, Doroshow, J H, Shurafa, M, Appelbaum, F R. Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group study. Blood, 98(12), 3212-20, 2001

Mathew, S, Head, D, Rubnitz, J E, Raimondi, S C. Concurrent translocations of MLL and CBFA2 (AML1) genes with new partner breakpoints in a child with secondary myelodysplastic syndrome after treatment of acute lymphoblastic leukemia. Genes Chromosomes Cancer, 28(2), 227-32, 2000

Altura, R A, Head, D R, Wang, W C. Long-term survival of infants with idiopathic myelofibrosis. Br J Haematol, 109(2), 459-62, 2000

Rodriguez-Galindo, C, Poquette, C A, Marina, N M, Head, D R, Cain, A, Meyer, W H, Santana, V M, Pappo, A S. Hematologic abnormalities and acute myeloid leukemia in children and adolescents administered intensified chemotherapy for the Ewing sarcoma family of tumors. J Pediatr Hematol Oncol, 22(4), 321-9, 2000

Chauncey, T R, Rankin, C, Anderson, J E, Chen, I, Kopecky, K J, Godwin, J E, Kalaycio, M E, Moore, D F, Shurafa, M S, Petersdorf, S H, Kraut, E H, Leith, C P, Head, D R, Luthardt, F W, Willman, C L, Appelbaum, F R. A phase I study of induction chemotherapy for older patients with newly diagnosed acute myeloid leukemia (AML) using mitoxantrone, etoposide, and the MDR modulator PSC 833: a southwest oncology group study 9617. Leuk Res, 24(7), 567-74, 2000

Rosen, P J, Rankin, C, Head, D R, Boldt, D H, Luthardt, F W, Norwood, T, Pugh, R P, Karanes, C, Appelbaum, F R. A phase II study of high dose ARA-C and mitoxantrone for treatment of relapsed or refractory adult acute lymphoblastic leukemia. Leuk Res, 24(3), 183-7, 2000

Mathew, S, Head, D, Rodriguez-Galindo, C, Raimondi, S C. Trisomy of the long arm of chromosome 1 resulting in a dicentric derivative (6)t(1;6) chromosome in a child with myelodysplastic syndrome following treatment for a primitive neuroectodermal tumor. Leuk Lymphoma, 37(1-2), 213-8, 2000

Slovak, M L, Kopecky, K J, Cassileth, P A, Harrington, D H, Theil, K S, Mohamed, A, Paietta, E, Willman, C L, Head, D R, Rowe, J M, Forman, S J, Appelbaum, F R. Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group/Eastern Cooperative Oncology Group Study. Blood, 96(13), 4075-83, 2000

Flinn, I W, Kopecky, K J, Foucar, M K, Head, D, Bennett, J M, Hutchison, R, Corbett, W, Cassileth, P, Habermann, T, Golomb, H, Rai, K, Eisenhauer, E, Appelbaum, F, Cheson, B, Grever, M R. Long-term follow-up of remission duration, mortality, and second malignancies in hairy cell leukemia patients treated with pentostatin. Blood, 96(9), 2981-6, 2000

Leach, C T, Frantz, C, Head, D R, Gao, S J, McClain, K L, Cohen, M, Campbell, A B, Pollock, B H, Murphy, S B, Jenson, H B. Human herpesvirus-8 (HHV-8) associated with small non-cleaved cell lymphoma in a child with AIDS. Am J Hematol, 60(3), 215-21, 1999

Navid, F, Mosijczuk, A D, Head, D R, Borowitz, M J, Carroll, A J, Brandt, J M, Link, M P, Rozans, M K, Thomas, G A, Schwenn, M R, Shields, D J, Vietti, T J, Pullen, D J. Acute lymphoblastic leukemia with the (8;14)(q24;q32) translocation and FAB L3 morphology associated with a B-precursor immunophenotype: the Pediatric Oncology Group experience. Leukemia, 13(1), 135-41, 1999

Leith, C P, Kopecky, K J, Chen, I M, Eijdems, L, Slovak, M L, McConnell, T S, Head, D R, Weick, J, Grever, M R, Appelbaum, F R, Willman, C L. Frequency and clinical significance of the expression of the multidrug resistance proteins MDR1/P-glycoprotein, MRP1, and LRP in acute myeloid leukemia: a Southwest Oncology Group Study. Blood, 94(3), 1086-99, 1999

Karanes, C, Kopecky, K J, Head, D R, Grever, M R, Hynes, H E, Kraut, E H, Vial, R H, Lichtin, A, Nand, S, Samlowski, W E, Appelbaum, F R. A phase III comparison of high dose ARA-C (HIDAC) versus HIDAC plus mitoxantrone in the treatment of first relapsed or refractory acute myeloid leukemia Southwest Oncology Group Study. Leuk Res, 23(9), 787-94, 1999

Chan, G C, Head, D R, Wang, W C. Refractory anemia with ringed sideroblasts in children: two diseases with a similar phenotype. J Pediatr Hematol Oncol, 21(5), 418-23, 1999

Cassileth, P A, Harrington, D P, Appelbaum, F R, Lazarus, H M, Rowe, J M, Paietta, E, Willman, C, Hurd, D D, Bennett, J M, Blume, K G, Head, D R, Wiernik, P H. Chemotherapy compared with autologous or allogeneic bone marrow transplantation in the management of acute myeloid leukemia in first remission. N Engl J Med, 339(23), 1649-56, 1998

Mohamed, A N, Varterasian, M L, Dobin, S M, McConnell, T S, Wolman, S R, Rankin, C, Willman, C L, Head, D R, Slovak, M L. Trisomy 6 as a primary karyotypic aberration in hematologic disorders. Cancer Genet Cytogenet, 106(2), 152-5, 1998

Godwin, J E, Kopecky, K J, Head, D R, Willman, C L, Leith, C P, Hynes, H E, Balcerzak, S P, Appelbaum, F R. A double-blind placebo-controlled trial of granulocyte colony-stimulating factor in elderly patients with previously untreated acute myeloid leukemia: a Southwest oncology group study (9031). Blood, 91(10), 3607-15, 1998

Atlas, M, Head, D, Behm, F, Schmidt, E, Zeleznik-Le, N H, Roe, B A, Burian, D, Domer, P H. Cloning and sequence analysis of four t(9;11) therapy-related leukemia breakpoints. Leukemia, 12(12), 1895-902, 1998

Pui, C H, Rubnitz, J E, Hancock, M L, Downing, J R, Raimondi, S C, Rivera, G K, Sandlund, J T, Ribeiro, R C, Head, D R, Relling, M V, Evans, W E, Behm, F G. Reappraisal of the clinical and biologic significance of myeloid-associated antigen expression in childhood acute lymphoblastic leukemia. J Clin Oncol, 16(12), 3768-73, 1998

Antill??n, F, Raimondi, S C, Fairman, J, Liang, H, Nagarajan, L, Head, D, Ribeiro, R C. 5q- in a child with refractory anemia with excess blasts: similarities to 5q- syndrome in adults. Cancer Genet Cytogenet, 105(2), 119-22, 1998

Pui, C H, Mahmoud, H H, Rivera, G K, Hancock, M L, Sandlund, J T, Behm, F G, Head, D R, Relling, M V, Ribeiro, R C, Rubnitz, J E, Kun, L E, Evans, W E. Early intensification of intrathecal chemotherapy virtually eliminates central nervous system relapse in children with acute lymphoblastic leukemia. Blood, 92(2), 411-5, 1998

Viswanatha, D S, Chen, I, Liu, P P, Slovak, M L, Rankin, C, Head, D R, Willman, C L. Characterization and use of an antibody detecting the CBFbeta-SMMHC fusion protein in inv(16)/t(16;16)-associated acute myeloid leukemias. Blood, 91(6), 1882-90, 1998

Kuefer, M U, Wang, W C, Head, D R, Wilimas, J A, Furman, W L, Liu, Q, Hornkohl, A C, Best, D M, Jackson, C W. Thrombopoietin level in young patients is related to megakaryocyte frequency and platelet count. J Pediatr Hematol Oncol, 20(1), 36-43, 1998

Rubnitz, J E, Downing, J R, Pui, C H, Shurtleff, S A, Raimondi, S C, Evans, W E, Head, D R, Crist, W M, Rivera, G K, Hancock, M L, Boyett, J M, Buijs, A, Grosveld, G, Behm, F G. TEL gene rearrangement in acute lymphoblastic leukemia: a new genetic marker with prognostic significance. J Clin Oncol, 15(3), 1150-7, 1997

Leith, C P, Kopecky, K J, Godwin, J, McConnell, T, Slovak, M L, Chen, I M, Head, D R, Appelbaum, F R, Willman, C L. Acute myeloid leukemia in the elderly: assessment of multidrug resistance (MDR1) and cytogenetics distinguishes biologic subgroups with remarkably distinct responses to standard chemotherapy. A Southwest Oncology Group study. Blood, 89(9), 3323-9, 1997

Chan, G C, Wang, W C, Raimondi, S C, Behm, F G, Krance, R A, Chen, G, Freiberg, A, Ingram, L, Butler, D, Head, D R. Myelodysplastic syndrome in children: differentiation from acute myeloid leukemia with a low blast count. Leukemia, 11(2), 206-11, 1997

Weick, J K, Kopecky, K J, Appelbaum, F R, Head, D R, Kingsbury, L L, Balcerzak, S P, Bickers, J N, Hynes, H E, Welborn, J L, Simon, S R, Grever, M. A randomized investigation of high-dose versus standard-dose cytosine arabinoside with daunorubicin in patients with previously untreated acute myeloid leukemia: a Southwest Oncology Group study. Blood, 88(8), 2841-51, 1996

Head, D R. Revised classification of acute myeloid leukemia. Leukemia, 10(11), 1826-31, 1996

Bowman, W P, Shuster, J J, Cook, B, Griffin, T, Behm, F, Pullen, J, Link, M, Head, D, Carroll, A, Berard, C, Murphy, S. Improved survival for children with B-cell acute lymphoblastic leukemia and stage IV small noncleaved-cell lymphoma: a pediatric oncology group study. J Clin Oncol, 14(4), 1252-61, 1996

Beck, W T, Grogan, T M, Willman, C L, Cordon-Cardo, C, Parham, D M, Kuttesch, J F, Andreeff, M, Bates, S E, Berard, C W, Boyett, J M, Brophy, N A, Broxterman, H J, Chan, H S, Dalton, W S, Dietel, M, Fojo, A T, Gascoyne, R D, Head, D, Houghton, P J, Srivastava, D K, Lehnert, M, Leith, C P, Paietta, E, Pavelic, Z P, Weinstein, R. Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: consensus recommendations. Cancer Res, 56(13), 3010-20, 1996

Kane, J R, Head, D R, Balazs, L, Hulshof, M G, Motroni, T A, Raimondi, S C, Carroll, A J, Behm, F G, Krance, R A, Shurtleff, S A, Downing, J R. Molecular analysis of the PML/RAR alpha chimeric gene in pediatric acute promyelocytic leukemia. Leukemia, 10(8), 1296-302, 1996

Slobod, K S, Bennett, T A, Freiden, P J, Kechli, A M, Howlett, N, Flynn, P M, Head, D R, Srivastava, D K, Boyett, J M, Brenner, M K, Garcia, J V. Mobilization of CD34+ progenitor cells by granulocyte colony-stimulating factor in human immunodeficiency virus type 1-infected adults. Blood, 88(9), 3329-35, 1996

Broniscer, A, Ribeiro, R C, Srinivas, R V, Behm, F G, Head, D R, Raimondi, S C, Mandrell, B, Gill, P. An adolescent with HTLV-I-associated adult T cell leukemia treated with interferon-alfa and zidovudine. Leukemia, 10(7), 1244-8, 1996

Tsai, T, Davalath, S, Rankin, C, Radich, J P, Head, D, Appelbaum, F R, Boldt, D H. Tumor suppressor gene alteration in adult acute lymphoblastic leukemia (ALL). Analysis of retinoblastoma (Rb) and p53 gene expression in lymphoblasts of patients with de novo, relapsed, or refractory ALL treated in Southwest Oncology Group studies. Leukemia, 10(12), 1901-10, 1996

Raimondi, S C, Frestedt, J L, Pui, C H, Downing, J R, Head, D R, Kersey, J H, Behm, F G. Acute lymphoblastic leukemias with deletion of 11q23 or a novel inversion (11)(p13q23) lack MLL gene rearrangements and have favorable clinical features. Blood, 86(5), 1881-6, 1995

Leith, C P, Chen, I M, Kopecky, K J, Appelbaum, F R, Head, D R, Godwin, J E, Weick, J K, Willman, C L. Correlation of multidrug resistance (MDR1) protein expression with functional dye/drug efflux in acute myeloid leukemia by multiparameter flow cytometry: identification of discordant MDR-/efflux+ and MDR1+/efflux- cases. Blood, 86(6), 2329-42, 1995

Kanwar, V S, Wang, W C, Winer-Muram, H T, Kauffman, W M, Gronemeyer, S A, Head, D R. Magnetic resonance imaging for evaluation of childhood aplastic anemia. J Pediatr Hematol Oncol, 17(4), 284-9, 1995

Head, D R, Behm, F G. Acute lymphoblastic leukemia and the lymphoblastic lymphomas of childhood. Semin Diagn Pathol, 12(4), 325-34, 1995

Licht, J D, Chomienne, C, Goy, A, Chen, A, Scott, A A, Head, D R, Michaux, J L, Wu, Y, DeBlasio, A, Miller, W H. Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17). Blood, 85(4), 1083-94, 1995

Downing, J R, Khandekar, A, Shurtleff, S A, Head, D R, Parham, D M, Webber, B L, Pappo, A S, Hulshof, M G, Conn, W P, Shapiro, D N. Multiplex RT-PCR assay for the differential diagnosis of alveolar rhabdomyosarcoma and Ewing's sarcoma. Am J Pathol, 146(3), 626-34, 1995

Head, D, Kopecky, K J, Weick, J, Files, J C, Ryan, D, Foucar, K, Montiel, M, Bickers, J, Fishleder, A, Miller, M. Effect of aggressive daunomycin therapy on survival in acute promyelocytic leukemia. Blood, 86(5), 1717-28, 1995

Bigelow, C L, Kopecky, K, Files, J C, Head, D, Lipschitz, D A, Grever, M, Appelbaum, F R. Treatment of acute myelogenous leukemia in patients over 50 years of age with V-TAD: a Southwest Oncology Group study. Am J Hematol, 48(4), 228-32, 1995

Hewlett, J, Kopecky, K J, Head, D, Eyre, H J, Elias, L, Kingsbury, L, Balcerzak, S P, Dabich, L, Hynes, H, Bickers, J N. A prospective evaluation of the roles of allogeneic marrow transplantation and low-dose monthly maintenance chemotherapy in the treatment of adult acute myelogenous leukemia (AML): a Southwest Oncology Group study. Leukemia, 9(4), 562-9, 1995

Okuda, T, Shurtleff, S A, Valentine, M B, Raimondi, S C, Head, D R, Behm, F, Curcio-Brint, A M, Liu, Q, Pui, C H, Sherr, C J. Frequent deletion of p16INK4a/MTS1 and p15INK4b/MTS2 in pediatric acute lymphoblastic leukemia. Blood, 85(9), 2321-30, 1995

Filatov, L V, Behm, F G, Pui, C H, Head, D R, Downing, J R, Raimondi, S C. Childhood acute lymphoblastic leukemia with equivocal chromosome markers of the t(1;19) translocation. Genes Chromosomes Cancer, 13(2), 99-103, 1995

Slovak, M L, Traweek, S T, Willman, C L, Head, D R, Kopecky, K J, Magenis, R E, Appelbaum, F R, Forman, S J. Trisomy 11: an association with stem/progenitor cell immunophenotype. Br J Haematol, 90(2), 266-73, 1995

Downing, J R, Shurtleff, S A, Zielenska, M, Curcio-Brint, A M, Behm, F G, Head, D R, Sandlund, J T, Weisenburger, D D, Kossakowska, A E, Thorner, P. Molecular detection of the (2;5) translocation of non-Hodgkin's lymphoma by reverse transcriptase-polymerase chain reaction. Blood, 85(12), 3416-22, 1995

Domer, P H, Head, D R, Renganathan, N, Raimondi, S C, Yang, E, Atlas, M. Molecular analysis of 13 cases of MLL/11q23 secondary acute leukemia and identification of topoisomerase II consensus-binding sequences near the chromosomal breakpoint of a secondary leukemia with the t(4;11). Leukemia, 9(8), 1305-12, 1995

Mehrotra, B, George, T I, Kavanau, K, Avet-Loiseau, H, Moore, D, Willman, C L, Slovak, M L, Atwater, S, Head, D R, Pallavicini, M G. Cytogenetically aberrant cells in the stem cell compartment (CD34+lin-) in acute myeloid leukemia. Blood, 86(3), 1139-47, 1995

Shurtleff, S A, Meyers, S, Hiebert, S W, Raimondi, S C, Head, D R, Willman, C L, Wolman, S, Slovak, M L, Carroll, A J, Behm, F. Heterogeneity in CBF beta/MYH11 fusion messages encoded by the inv(16)(p13q22) and the t(16;16)(p13;q22) in acute myelogenous leukemia. Blood, 85(12), 3695-703, 1995

Grever, M, Kopecky, K, Foucar, M K, Head, D, Bennett, J M, Hutchison, R E, Corbett, W E, Cassileth, P A, Habermann, T, Golomb, H. Randomized comparison of pentostatin versus interferon alfa-2a in previously untreated patients with hairy cell leukemia: an intergroup study. J Clin Oncol, 13(4), 974-82, 1995

Gallego, M, Carroll, A J, Gad, G S, Pappo, A, Head, D, Behm, F, Ravindranath, Y, Raimondi, S C. Variant t(8;21) rearrangements in acute myeloblastic leukemia of childhood. Cancer Genet Cytogenet, 75(2), 139-44, 1994

Radich, J P, Kopecky, K J, Boldt, D H, Head, D, Slovak, M L, Babu, R, Kirk, J, Lee, A, Kessler, P, Appelbaum, F. Detection of BCR-ABL fusion genes in adult acute lymphoblastic leukemia by the polymerase chain reaction. Leukemia, 8(10), 1688-95, 1994

Boldt, D H, Kopecky, K J, Head, D, Gehly, G, Radich, J P, Appelbaum, F R. Expression of myeloid antigens by blast cells in acute lymphoblastic leukemia of adults. The Southwest Oncology Group experience. Leukemia, 8(12), 2118-26, 1994

Downing, J R, Head, D R, Raimondi, S C, Carroll, A J, Curcio-Brint, A M, Motroni, T A, Hulshof, M G, Pullen, D J, Domer, P H. The der(11)-encoded MLL/AF-4 fusion transcript is consistently detected in t(4;11)(q21;q23)-containing acute lymphoblastic leukemia. Blood, 83(2), 330-5, 1994

Pui, C H, Behm, F G, Downing, J R, Hancock, M L, Shurtleff, S A, Ribeiro, R C, Head, D R, Mahmoud, H H, Sandlund, J T, Furman, W L. 11q23/MLL rearrangement confers a poor prognosis in infants with acute lymphoblastic leukemia. J Clin Oncol, 12(5), 909-15, 1994

Scott, A A, Head, D R, Kopecky, K J, Appelbaum, F R, Theil, K S, Grever, M R, Chen, I M, Whittaker, M H, Griffith, B B, Licht, J D. HLA-DR-, CD33+, CD56+, CD16- myeloid/natural killer cell acute leukemia: a previously unrecognized form of acute leukemia potentially misdiagnosed as French-American-British acute myeloid leukemia-M3. Blood, 84(1), 244-55, 1994

Sawyer, J R, Roloson, G J, Head, D R, Becton, D. Karyotype evolution in a patient with Down syndrome and acute leukemia following a congenital leukemoid reaction. Med Pediatr Oncol, 22(6), 404-9, 1994

Head, D R, Kopecky, K J, Willman, C, Appelbaum, F R. Treatment outcome with chemotherapy in acute promyelocytic leukemia: the Southwest Oncology Group (SWOG) experience. Leukemia, 8 Suppl 2, S38-41, 1994

Mirro, J, Hurwitz, C A, Behm, F G, Head, D R, Raimondi, S C, Crist, W M, Ihle, J N. Effects of recombinant human hematopoietic growth factors on leukemic blasts from children with acute myeloblastic or lymphoblastic leukemia. Leukemia, 7(7), 1026-33, 1993

Ribeiro, R C, Oliveira, M S, Fairclough, D, Hurwitz, C, Mirro, J, Behm, F G, Head, D, Silva, M L, Raimondi, S C, Crist, W M. Acute megakaryoblastic leukemia in children and adolescents: a retrospective analysis of 24 cases. Leuk Lymphoma, 10(4-5), 299-306, 1993

Downing, J R, Head, D R, Curcio-Brint, A M, Hulshof, M G, Motroni, T A, Raimondi, S C, Carroll, A J, Drabkin, H A, Willman, C, Theil, K S. An AML1/ETO fusion transcript is consistently detected by RNA-based polymerase chain reaction in acute myelogenous leukemia containing the (8;21)(q22;q22) translocation. Blood, 81(11), 2860-5, 1993

Sandoval, C, Pui, C H, Bowman, L C, Heaton, D, Hurwitz, C A, Raimondi, S C, Behm, F G, Head, D R. Secondary acute myeloid leukemia in children previously treated with alkylating agents, intercalating topoisomerase II inhibitors, and irradiation. J Clin Oncol, 11(6), 1039-45, 1993

Cant??-Rajnoldi, A, Biondi, A, Jankovic, M, Masera, G, Rovelli, A, Uderzo, C, Head, D, Raimondi, S, Creutzig, V, Ritter, J. Diagnosis and incidence of acute promyelocytic leukemia (FAB M3 and M3 variant) in childhood. Blood, 81(8), 2209-10, 1993

Elias, L, Stock-Novack, D, Head, D R, Grever, M R, Weick, J K, Chapman, R A, Godwin, J E, Metz, E N, Appelbaum, F R. A phase I trial of combination fludarabine monophosphate and chlorambucil in chronic lymphocytic leukemia: a Southwest Oncology Group study. Leukemia, 7(3), 361-5, 1993

Koehler, M, Behm, F G, Shuster, J, Crist, W, Borowitz, M, Look, A T, Head, D, Carroll, A J, Land, V, Steuber, P. Transitional pre-B-cell acute lymphoblastic leukemia of childhood is associated with favorable prognostic clinical features and an excellent outcome: a Pediatric Oncology Group study. Leukemia, 7(12), 2064-8, 1993

Downing, J R, Head, D R, Parham, D M, Douglass, E C, Hulshof, M G, Link, M P, Motroni, T A, Grier, H E, Curcio-Brint, A M, Shapiro, D N. Detection of the (11;22)(q24;q12) translocation of Ewing's sarcoma and peripheral neuroectodermal tumor by reverse transcription polymerase chain reaction. Am J Pathol, 143(5), 1294-300, 1993

Gad, S G, Callen, D F, Kuss, B, Downing, J R, Behm, F, Head, D, Ribeiro, R C, Raimondi, S C. Identification of an inversion 16 coexisting with an isochromosome 22q by in situ hybridization in a case of childhood AML M4e. Leukemia, 7(10), 1658-62, 1993

Pui, C H, Hancock, M L, Head, D R, Rivera, G K, Look, A T, Sandlund, J T, Behm, F G. Clinical significance of CD34 expression in childhood acute lymphoblastic leukemia. Blood, 82(3), 889-94, 1993

Raimondi, S C, Pui, C H, Head, D R, Rivera, G K, Behm, F G. Cytogenetically different leukemic clones at relapse of childhood acute lymphoblastic leukemia. Blood, 82(2), 576-80, 1993

Sandoval, C, Head, D R, Mirro, J, Behm, F G, Ayers, G D, Raimondi, S C. Translocation t(9;11)(p21;q23) in pediatric de novo and secondary acute myeloblastic leukemia. Leukemia, 6(6), 513-9, 1992

Raimondi, S C, Pui, C H, Head, D, Behm, F, Privitera, E, Roberson, P K, Rivera, G K, Williams, D L. Trisomy 21 as the sole acquired chromosomal abnormality in children with acute lymphoblastic leukemia. Leukemia, 6(3), 171-5, 1992

Abshire, T C, Buchanan, G R, Jackson, J F, Shuster, J J, Brock, B, Head, D, Behm, F, Crist, W M, Link, M, Borowitz, M. Morphologic, immunologic and cytogenetic studies in children with acute lymphoblastic leukemia at diagnosis and relapse: a Pediatric Oncology Group study. Leukemia, 6(5), 357-62, 1992

Betz, S A, Foucar, K, Head, D R, Chen, I M, Willman, C L. False-positive flow cytometric platelet glycoprotein IIb/IIIa expression in myeloid leukemias secondary to platelet adherence to blasts. Blood, 79(9), 2399-403, 1992

Head, D R, Downing, J R. Pathology and immunology of leukemia. Curr Opin Oncol, 4(1), 14-23, 1992

Ryan, D H, Kopecky, K J, Head, D, Grever, M R, Shiaer, S M, Lipschitz, D A, Hynes, H E, Vial, R H, Veith, R W, Gumbart, C H. Analysis of treatment failure in acute nonlymphocytic leukemia patients over fifty years of age. A Southwest Oncology Group study. Am J Clin Oncol, 15(1), 69-75, 1992

Pui, C H, Carroll, A J, Raimondi, S C, Schell, M J, Head, D R, Shuster, J J, Crist, W M, Borowitz, M J, Link, M P, Behm, F G. Isochromosomes in childhood acute lymphoblastic leukemia: a collaborative study of 83 cases. Blood, 79(9), 2384-91, 1992

Morrison, F S, Kopecky, K J, Head, D R, Athens, J W, Balcerzak, S P, Gumbart, C, Dabich, L, Costanzi, J J, Coltman, C A, Saiki, J H. Late intensification with POMP chemotherapy prolongs survival in acute myelogenous leukemia--results of a Southwest Oncology Group study of rubidazone versus adriamycin for remission induction, prophylactic intrathecal therapy, late intensification, and levamisole maintenance. Leukemia, 6(7), 708-14, 1992

Chan, W C, Carroll, A, Alvarado, C S, Phillips, S, Gonzalez-Crussi, F, Kurczynski, E, Pappo, A, Emami, A, Bowman, P, Head, D R. Acute megakaryoblastic leukemia in infants with t(1;22)(p13;q13) abnormality. Am J Clin Pathol, 98(2), 214-21, 1992

Miller, K B, Kim, K, Morrison, F S, Winter, J N, Bennett, J M, Neiman, R S, Head, D R, Cassileth, P A, O'Connell, M J, Kyungmann, K. The evaluation of low-dose cytarabine in the treatment of myelodysplastic syndromes: a phase-III intergroup study. Ann Hematol, 65(4), 162-8, 1992

Hurwitz, C A, Raimondi, S C, Head, D, Krance, R, Mirro, J, Kalwinsky, D K, Ayers, G D, Behm, F G. Distinctive immunophenotypic features of t(8;21)(q22;q22) acute myeloblastic leukemia in children. Blood, 80(12), 3182-8, 1992

Cerezo, L, Shuster, J J, Pullen, D J, Brock, B, Borowitz, M J, Falletta, J M, Crist, W M, Head, D R. Laboratory correlates and prognostic significance of granular acute lymphoblastic leukemia in children. A Pediatric Oncology Group study. Am J Clin Pathol, 95(4), 526-31, 1991

Willman, C L, Stewart, C C, Longacre, T L, Head, D R, Habbersett, R, Ziegler, S F, Perlmutter, R M. Expression of the c-fgr and hck protein-tyrosine kinases in acute myeloid leukemic blasts is associated with early commitment and differentiation events in the monocytic and granulocytic lineages. Blood, 77(4), 726-34, 1991

Pui, C H, Frankel, L S, Carroll, A J, Raimondi, S C, Shuster, J J, Head, D R, Crist, W M, Land, V J, Pullen, D J, Steuber, C P. Clinical characteristics and treatment outcome of childhood acute lymphoblastic leukemia with the t(4;11)(q21;q23): a collaborative study of 40 cases. Blood, 77(3), 440-7, 1991

Saikevych, I A, Kerrigan, D P, McConnell, T S, Head, D R, Appelbaum, F R, Willman, C L. Multiparameter analysis of acute mixed lineage leukemia: correlation of a B/myeloid immunophenotype and immunoglobulin and T-cell receptor gene rearrangements with the presence of the Philadelphia chromosome translocation in acute leukemias with myeloid morphology. Leukemia, 5(5), 373-82, 1991

Carter, M, Kalwinsky, D K, Mirro, J, Behm, F G, Head, D, Huddleston, T F, Raimondi, S C. The t(10;11)(p14;q21) translocation in three children with acute myeloblastic leukemia. Leukemia, 5(7), 561-5, 1991

Pui, C H, Raimondi, S C, Head, D R, Schell, M J, Rivera, G K, Mirro, J, Crist, W M, Behm, F G. Characterization of childhood acute leukemia with multiple myeloid and lymphoid markers at diagnosis and at relapse. Blood, 78(5), 1327-37, 1991

Eguiguren, J M, Ribeiro, R C, Pui, C H, Hancock, M L, Pratt, C B, Head, D R, Crist, W M. Secondary non-Hodgkin's lymphoma after treatment for childhood cancer. Leukemia, 5(10), 908-11, 1991

Pui, C H, Ribeiro, R C, Hancock, M L, Rivera, G K, Evans, W E, Raimondi, S C, Head, D R, Behm, F G, Mahmoud, M H, Sandlund, J T. Acute myeloid leukemia in children treated with epipodophyllotoxins for acute lymphoblastic leukemia. N Engl J Med, 325(24), 1682-7, 1991

Sullivan, M P, Pullen, D J, Crist, W M, Brecher, M, Ramirez, I, Sabio, H, Borowitz, M J, Head, D R, Cerezo, L, Shuster, J J. Clinical and biological heterogeneity of childhood B cell acute lymphocytic leukemia: implications for clinical trials. Leukemia, 4(1), 6-11, 1990

Cheson, B D, Cassileth, P A, Head, D R, Schiffer, C A, Bennett, J M, Bloomfield, C D, Brunning, R, Gale, R P, Grever, M R, Keating, M J. Report of the National Cancer Institute-sponsored workshop on definitions of diagnosis and response in acute myeloid leukemia. J Clin Oncol, 8(5), 813-9, 1990

Crist, W, Carroll, A, Shuster, J, Jackson, J, Head, D, Borowitz, M, Behm, F, Link, M, Steuber, P, Ragab, A. Philadelphia chromosome positive childhood acute lymphoblastic leukemia: clinical and cytogenetic characteristics and treatment outcome. A Pediatric Oncology Group study. Blood, 76(3), 489-94, 1990

Jackson, J F, Boyett, J, Pullen, J, Brock, B, Patterson, R, Land, V, Borowitz, M, Head, D, Crist, W. Favorable prognosis associated with hyperdiploidy in children with acute lymphocytic leukemia correlates with extra chromosome 6. A Pediatric Oncology Group study. Cancer, 66(6), 1183-9, 1990

Radich, J P, Kopecky, K J, Willman, C L, Weick, J, Head, D, Appelbaum, F, Collins, S J. N-ras mutations in adult de novo acute myelogenous leukemia: prevalence and clinical significance. Blood, 76(4), 801-7, 1990

Pui, C H, Carroll, A J, Head, D, Raimondi, S C, Shuster, J J, Crist, W M, Link, M P, Borowitz, M J, Behm, F G, Land, V J. Near-triploid and near-tetraploid acute lymphoblastic leukemia of childhood. Blood, 76(3), 590-6, 1990

Pui, C H, Hancock, M L, Raimondi, S C, Head, D R, Thompson, E, Wilimas, J, Kun, L E, Bowman, L C, Crist, W M, Pratt, C B. Myeloid neoplasia in children treated for solid tumours. Lancet, 336(8712), 417-21, 1990

Hussein, K K, Dahlberg, S, Head, D, Waddell, C C, Dabich, L, Weick, J K, Morrison, F, Saiki, J H, Metz, E, Rivkin, S E. Treatment of acute lymphoblastic leukemia in adults with intensive induction, consolidation, and maintenance chemotherapy. Blood, 73(1), 57-63, 1989

Crist, W, Boyett, J, Jackson, J, Vietti, T, Borowitz, M, Chauvenet, A, Winick, N, Ragab, A, Mahoney, D, Head, D. Prognostic importance of the pre-B-cell immunophenotype and other presenting features in B-lineage childhood acute lymphoblastic leukemia: a Pediatric Oncology Group study. Blood, 74(4), 1252-9, 1989

Head, D R, Kopecky, K, Bennett, J M, Grenier, K, Morrison, F S, Miller, K B, Grever, M R. Pathogenetic implications of internuclear bridging in myelodysplastic syndrome. An Eastern Cooperative Oncology Group/Southwest Oncology Group Cooperative Study. Cancer, 64(11), 2199-2202, 1989

Head, D R, Avakian, J, Kjeldsberg, C R, Cerezo, L. Relapse of intermediate or high-grade (unfavorable) non-Hodgkin's lymphoma as a low-grade (favorable) Non-Hodgkin's lymphoma. Report of four cases. Am J Clin Pathol, 89(1), 106-8, 1988

Frame, R, Head, D, Lee, R, Craven, C, Ward, J H. Granulocytic sarcoma of the prostate. Two cases causing urinary obstruction. Cancer, 59(1), 142-6, 1987

Ryan, D H, Kopecky, K J, Head, D, Gumbart, C N, Grever, M R, Karanes, C, Weick, J K, Coltman, C A. Phase II evaluation of teniposide and ifosfamide in refractory adult acute lymphocytic leukemia: a Southwest Oncology Group Study. Cancer Treat Rep, 71(7-8), 713-6, 1987

Head, D R, Kjeldsberg, C R, Kadin, M E, Pick, T, Bybee, B, Longbotham, J, Shumski, E. Childhood T-cell malignancy resembling adult T-cell leukemia/lymphoma. Hematol Pathol, 1(1), 15-25, 1987

Cerezo, L, Head, D R. Immunologic phenotype of acute lymphoblastic leukemias. Hum Pathol, 18(10), 1078, 1987

van Eys, J, Pullen, J, Head, D, Boyett, J, Crist, W, Falletta, J, Humphrey, G B, Jackson, J, Riccardi, V, Brock, B. The French-American-British (FAB) classification of leukemia. The Pediatric Oncology Group experience with lymphocytic leukemia. Cancer, 57(5), 1046-51, 1986

Beck, L S, Strickland, R D, Bagley, B L, Mortensen, J D, Hammond, M E, Ashton, A H, Head, D R, Braun, M R, Weiler, M J. Large-animal model of chronic congestive heart failure induced by intracoronary allylamine. ASAIO Trans, 32(1), 238-41, 1986

Head, D R, Hughes, K, Marty, J. The bone marrow biopsy: a diagnostic strategy. Arch Pathol Lab Med, 110(12), 1120-1, 1986

Head, D R, Borowitz, M, Cerezo, L, Craven, C M, Brock, B L, Boyett, J M, Pullen, D J, Crist, W M, Falletta, J, Humphrey, G B. Acid phosphatase positivity in childhood acute lymphocytic leukemia. Am J Clin Pathol, 86(5), 650-3, 1986

Head, D R. Whole blood versus packed red cells. Transfusion, 25(6), 591, 1985

Head, D R, Savage, R A, Cerezo, L, Craven, C M, Bickers, J N, Hartsock, R, Hosty, T A, Saiki, J H, Wilson, H E, Morrison, F S. Reproducibility of the French-American-British classification of acute leukemia: the Southwest Oncology Group Experience. Am J Hematol, 18(1), 47-57, 1985

Head, D R, Cerezo, L, Savage, R A, Craven, C M, Bickers, J N, Hartsock, R, Hosty, T A, Saiki, J H, Wilson, H E, Morrison, F S. Institutional performance in application of the FAB classification of acute leukemia. The Southwest Oncology Group experience. Cancer, 55(9), 1979-86, 1985

Spier, C M, Kjeldsberg, C R, Head, D R, DiFiore, K C, Tudor, B. Chronic lymphocytic leukemia in young adults. Am J Clin Pathol, 84(5), 675-8, 1985

Cerezo, L, Head, D R, Pullen, J, Humphrey, B. The prevalence of hand-mirror cells in acute myeloblastic and lymphoblastic leukemia. Am J Clin Pathol, 81(3), 355-7, 1984

Herrera, G A, Head, D R. Histiocytic lymphoma arising at the site of injection of anti-lymphocytic globulin: necropsy follow-up of previously reported case. Mil Med, 146(9), 652-4, 1981

McCue, M J, Brossoit, A D, Marmer, D J, Head, D R. Von Willebrand Factor (VIIIVWF) in lyophilized Factor VIII concentrates. Am J Hematol, 9(1), 39-42, 1980

Head, D R, Bowman, R P, Marmer, D J, Brossoit, A D. An improvemed assay for von Willebrand factor. Am J Clin Pathol, 72(6), 991-5, 1979

Head, D R, Kennedy, P S, Goyette, R E. Metastatic neuroblastoma in bone marrow aspirate smears. Am J Clin Pathol, 72(6), 1008-11, 1979

Karcher, D S, Head, D R, Mullins, J D. Malignant histiocytosis occurring in patients with acute lymphocytic leukemia. Cancer, 41(5), 1967-73, 1978

Haburchak, D R, Head, D R, Everett, E D. Postoperative hemorrhage associated with carbenicillin administration. Report of two cases and review of the literature. Am J Surg, 134(5), 630-4, 1977

Head, D R, Bowman, R P, Marmer, D J, Brossoit, A D. Von Willebrand's disease. N Engl J Med, 297(10), 558, 1977

Zuck, T F, Head, D R. Blood-transfusion in the presence of haemolytic anaemia. Lancet, 2(7720), 382-3, 1971