Department of Pathology, Microbiology, and Immunology

Charles W. Stratton, M.D.

Associate Professor

Dept of Pathology, Microbiology and Immunology

Director, Clinical Microbiology

Contact Information

Office Location:

4525 TVC

Phone: 615-343-9063

Fax: 615-343-8420

E-mail: charles.stratton@vanderbilt.edu

Campus Mail address:

Pathology Labs/Blood Bank

4605 TVC (5310)

US Mailing address:

Vanderbilt University School of Medicine

Pathology Labs/Blood Bank

4605 TVC

Nashville, TN 37232-5310

Education

M.D., University of Vermont College of Medicine, Burlington, Vermont
B.S., Bates College, Lewiston, Maine

Research Keywords

Research Description

Emerging infectious diseases are a recognized problem in clinical medicine. Chlamydia pneumoniae was first recognized in 1988 as a cause of community acquired respiratory tract infections. Since then, this unique pathogen has been associated with a number of chronic diseases, including atherosclerosis and asthma. The pathogenesis of Chlamydia pneumoniae and its role in chronic inflammatory diseases as a cause of secondary infection worsening the original inflammatory process is the basis of current research efforts.

Publications

Stratton CW, Wheldon DB. Multiple sclerosis: an infectious syndrome involving Chlamydophila pneumoniae.. Trends Microbiol, 2006
Sriram, S., Yao, S.Y., Stratton, C.W., Moses, H. Narayana, P.A., Wolinsky, J.S.. Pilot study to examine the effect of antibiotic therapy on MRI outcomes in RRMS. . J. Neurol. Sci. , 234, 87-91, 2005
Stratton CW, Sriram S. Association of Chlamydia pneumoniae with central nervous system disease.. Microbes Infect. , 5(13), 1249-1253, 2003
Sams HH, Mitchell WM, Stratton CW, King LE. Culture and immunhistochemical evidence of Chlamydia pneumoniae in pyoderma gangrenosum. Journal of the American Academy of Dermatology, 48, 966-969, 2003
Sriram S, Yao S, Mitchell WM, Calibresi P, Stratton CW, Ikejima H, Yamamoto Y. Comparative study of the presence of Chlamydia pneumoniae in cerebrospinal fluid from clinically definite and monosympomatic muliple sclerosis patinets. Clinical and Diagnostic Laboratory Immunology, 9, 1332-1337, 2003
Alberts GL, Mitchell WM, Stratton CW, Franke JJ. Interstitial cystitis: can Chlamydia pneumoniae be a cause?. Infections in Urology, 16, 19-21, 2003
King LE Jr, Stratton CW, Mitchell WM. Chlamydia pneumoniae and chronic skin infections: a focused review. Journal of Investigative Dermatology Symposium Proceedings, 6, 233-237, 2002
Yoa S, Stratton CW, Mitchell WM, Sriram S. Cerebral spinal fluid oligoclonal bands in multiple sclerosis represent antibodies against Chlamydiophila. Neurology, 56, 1168-1176, 2001
Yao SY, Rose A, Stratton CW, Mitchell WM, Sriram S. Regulation by beta interferon of inducible nitric oxide synthase and interleukin 12/p40 in murine macrophages exposed to Chlamydia pneumoniae antigens. Journal of Interferon and Cytokine Research, 21, 137-146, 2001
King LE Jr, Bushman T, Stratton CW, Mitchell WM. Diabetic foot ulcers and Chlamydia pneumoniae: innocent bystander or opportunistic pathogen. Archives of Dermatology, 42, 295-297, 2001
Vannucci SA, Mithcell WM, Stratton CW, King LE Jr. Pyoderma gangrenosum and Chlamydia pneumoniae infection in a diabetic man: pahtognic role or coincidence?. Journal of the American Academy of Dermatology, 42, 295-297, 2000
Stratton CW, Warner RR, Coudron PE, Lilly NA. Bismuth- mediated disruption of the glycocalyx-cell wall of Helicobacter pylori ultrastructure evidence for a mechanism of action for bismuth salts. Journal of Antimicrobial Chemotherapy , 43, 659-666, 1999
Coudron PE, Stratton CW. In-vitro evaluation of nitrofurantoin as an alternative agent for metronidazole in combination antimicrobial therapy against Helicobacter pylori. Journal of Antimicrobial Chemotherapy, 42, 657-660, 1998
Sriram S, Mitchell W, Stratton C. Multiple sclerosis associated with Chlamydia pneumoniae infection of the CNS. Neurology, 50, 571-573, 1998
Norris SR, Stratton CW, Kernodle DS. Production of A and C variants of staphylococcal beta-lactamase by methicillin-resistant strains of Staphylococcus aureus. Antimicrobial Agents and Chemotherapy , 38, 1649-1650, 1994
Macon WR, Lo SC, Poiesz BJ, Montefiori DC, Masn TE, Michael PR, Cohen AG, Davis CM, Cousar JM, Stratton CW. AIDS-like illness associated with Mycoplasma fermentans (incognetus strain) infection in an HIV-negative homosexual male. Human Pathology , 24, 554-557, 1993
Zygmunt DJ, Stratton CW, Kernodle DS. Characterization of four beta-lactamases produced by Staphylococcus aureus.. Antimicrobial Agents and Chemotherapy , 36, 440-445, 1992