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Name
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Research Specialty
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Molecular genetic analysis of cancer initiation and progression with emphasis on prostate cancer |
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Intracellular signaling pathways in normal CNS development and neoplasia |
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Molecular biology of human immunodeficiency viruses |
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Chronic bacterial inflammation (model organism Helicobacter); Th17 cell responses; Bacterial responses to inflammation |
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Mechanisms of cardiovascular disease (atherosclerosis/ cardiovascular disease /heart transplantation) |
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The use of functional genomic and epigenetic approaches to understand gene regulation. |
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Post-translational modifications that regulate signal transduction in the mammalian immune system |
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Regulation of blood coagulation proteolytic enzymes |
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Signaling; transcription factors; lymphocyte functions |
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Evolutionary and functional genomics of animal microbiomes |
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Type IV collagen in the pathogenesis of autoimmune glomerulonephritis and hereditary nephropathies |
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Pathology of Genetically Engineered Mice |
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Selenium metabolism and function in animals and human beings |
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Pathologic and molecular diagnosis of bone and soft tissue tumors |
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Post-transcriptional regulation of mammalian reovirus RNA |
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Inflammatory myofibroblastic and other soft tumors |
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Bacteria-host interactions, bacterial toxins, Helicobacter pylori, and gastric cancer |
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Virology, immunology, vaccine research |
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Connective tissue research; Wound healing; Gene therapy |
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Coronavirus Replication, Cell Biology and Experimental Evolution; Emerging Infections; Synthetic Biology |
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Chikungunya virus and reovirus cell entry, replication, and pathogenesis; reovirus-based vaccine vectors; oncolytic reovirus therapeutics |
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The role of infectious agents in idiopathic pulmonary diseases with an emphasis on CD4+ T cell immunology, pathogenic mycobacteria, and granulomatous inflammation |
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Gene regulation of tumor development |
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Macrophage-based gene therapy of hypercholesterolemia and atherosclerosis |
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Role of growth factors in the progression and potential regression of chronic renal disease |
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Regulation of hemostasis |
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Epidemiology, microbiology, and vaccine development of E. coli intestinal pathogens |
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| Hadjifrangiskou, Maria |
Bacterial virulence gene regulation; pathogenesis of urinary tract infections |
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Cell-cell interactions emphasizing leukocyte-endothelial systems; endothelial cell biology |
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Collagen biochemistry; matrix biology |
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| Irish, Jonathan |
Single cell systems biology for translational cancer and immunology research |
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The role of lysosomes in abnormal cholesterol metabolism, atherosclerosis, and cancer. |
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Understanding how antigen processing and presentation regulate T lymphocyte function in health and disease: How is T cell development and survival regulated? What do T cells recognize? How are these molecules processed for proper recognition? How does antigen processing and presentation lead to the induction of the proper immune response? |
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T cell responses to HIV infection |
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B lymphocyte tolerance in type 1 diabetes |
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Tuberculosis vaccine development, staphylococcal vaccine development, antibiotic resistance mechanisms |
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miRNA expression in myeloid neoplasms |
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Bacterial protein toxins, structural biology |
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Fatty Acid Abnormalities in Cystic Fibros |
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Functional genomics and systems biology analysis of the immune response and gene expression |
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The role of innate and adaptive immunity in atherosclerosis |
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Oxidants and hypoxia-stimulated endothelial prostanoid systhesis; role of inflammation in the pathogenesis of chronic pulmonary hypertension |
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Role of TGF-beta in breast and pancreatic cancer initiation and progression |
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Tumor dysregulation of apoptosis pathways leading to T cell induced apoptosis resistance |
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Cellular and molecular mechanisms controlling growth and differentiation in the female reproductive tract |
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Amphibian immune defenses, antimicrobial peptide defenses, developmental and comparative immunology, Chytridiomycosis and global amphibian declines |
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Genetic analysis of growth control and development |
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Structure and biology of integrin adhesive receptors for extracellular matrix proteins |
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Combined molecular/cellular analysis of the adaptive and innate immune systems |
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Regulation of fatty acid metabolism in cystic fibrosis and hematolymphoid malignancies |
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Control of matrix directed capillary morphogenesis |
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Expression and regulation of macrophage cell surface receptors |
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Bacteriology and innate immunity |
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Structural Biology of ion channels, virulence factors, host-pathogen relationship, and cytoskeletal regulation |
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Lipoprotein metabolism, lipid droplet formation, adipocyte biology |
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Molecular Basis of Microorganism-Related Diseases |
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Mechanisms that regulate immune tolerance and why they fail in autoimmune disorders such as type 1 diabetes |
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Mechanisms of Environmental Neurotoxicants |
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Immune regulation, MHC class I molecules, glycolipid-reactive T cells, mucosal immunity, autoimmunity |
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Regulation of blood coagulation proteolytic enzymes |
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Administration of animal research resources, Post-graduate training of veterinarians in laboratory animal and comparative medicine, Collaborative research involving animal models of human disease |
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Histopathology of gastrointestinal and hepatic diseases and mouse models of GI cancer |
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Dynamic actin assembly for cell motility and cancer metastasis |
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Mucosal immunology and inflammation; macrophages; arginine metabolism, nitric oxide, and polyamines; host-pathogen interactions; Helicobacter pylori, colitis |
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Clinical Chemistry, clinical endocrinology, biomarkers of maternal/fetal medicine, sepsis |
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Role of vasculogenesis in tumor neovascularization. Artery and vein specific gene expression |
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Tumor cell invasion and cancer metastasis |
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Integrin-mediated cell adhesion in development, cancer, innate immunity and vascular biology |
This page was last updated April 24, 2013 and is maintained by Andries Zijlstra