.

Department of Pathology, Microbiology, and Immunology

ELECTRON MICROSCOPY

Electron microscopy (EM) is valuable in addressing a wide variety of anatomic pathology problems. These include:   

  1. Neoplasms: mesothelioma vs. carcinoma
    1.  small round blue cell tumors
    2.  spindle cell tumors
    3. Melanoma
    4. neuroendocrine tumors
    5. undifferentiated tumors   
2.  Storage diseases
3.  Cilia disorders (immotile cilia diseases)
4.  Infectious diseases: viral diseases
5.  *Whipple's disease and microsporidia
6.  Miscellaneous: congenital bullous skin diseases  
  
In addition to tissue samples, representative H & E-stained slides as well as a completed EM requisition should be sent. Please also provide the results of any other studies (i.e. immunohistochemistry) to aid in our diagnostic evaluation. Tissue processing for EM requires 2-3 days. Results are reported by telephone, fax, and a final printed report.
 
Samples can be shipped at ambient temperature. We can provide glutaraldehyde fixative, EM requisitions, and pre-printed airbills upon request. Samples are accepted Monday through Friday.
 
Samples in 2% glutaraldehyde may be multiple, but should not exceed 1mm in dimension because of the penetrating abilities of this fixative. If glutaraldehyde is unavailable please contact us by phone 615-322-3070 or by e-mail, and we will provide you with specimen containers containing this fixative. Formalin, or other fixed tissue is also usually adequate if no glutaraldehyde is available. Sometimes a paraffin embedded specimen can be used, but with some sacrifice of quality.  

This page was last updated December 30, 2008 and is maintained by