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Shah, VB, Shi, J, Hout, DR, Oztop, I, Krishnan, L, Ahn, J, Shotwell, MS, Engelman, A, Aiken, C. The Host Proteins Transportin SR2/TNPO3 and Cyclophilin A Exert Opposing Effects on HIV-1 Uncoating. J Virol, 87(1), 422-32, 2013
Yang, R, Shi, J, Byeon, IJ, Ahn, J, Sheehan, JH, Meiler, J, Gronenborn, AM, Aiken, C. Second-site suppressors of HIV-1 capsid mutations: restoration of intracellular activities without correction of intrinsic capsid stability defects. Retrovirology, 9, 30, 2012
Yang H, Ji X, Zhao G, Ning J, Zhao Q, Aiken C, Gronenborn AM, Zhang P, Xiong Y. Structural insight into HIV-1 capsid recognition by rhesus TRIM5??. Proc Natl Acad Sci USA, 109, 18372-7, 2012
Shi, J, Zhou, J, Shah, VB, Aiken, C, Whitby, K. Small-molecule inhibition of human immunodeficiency virus type 1 infection by virus capsid destabilization. J Virol, 85(1), 542-9, 2011
Joyner, AS, Willis, JR, Crowe, JE, Aiken, C. Maturation-induced cloaking of neutralization epitopes on HIV-1 particles. PLoS Pathog, 7(9), e1002234, 2011
Shah, VB, Aiken, C. In vitro uncoating of HIV-1 cores. J Vis Exp(57), 2011
Joyner AS, Willis J, Crowe Jr. JE, Aiken C. Maturation-Induced Cloaking of Neutralization Epitopes on HIV-1 Particles. PLoS Pathog, 9, e1002234, 2011
Du, S, Betts, L, Yang, R, Shi, H, Concel, J, Ahn, J, Aiken, C, Zhang, P, Yeh, JI. Structure of the HIV-1 full-length capsid protein in a conformationally trapped unassembled state induced by small-molecule binding. J Mol Biol, 406(3), 371-86, 2011
Zhao, G, Ke, D, Vu, T, Ahn, J, Shah, VB, Yang, R, Aiken, C, Charlton, LM, Gronenborn, AM, Zhang, P. Rhesus TRIM5I? disrupts the HIV-1 capsid at the inter-hexamer interfaces. PLoS Pathog, 7(3), e1002009, 2011
Matei, E, Zheng, A, Furey, W, Rose, J, Aiken, C, Gronenborn, AM. Anti-HIV activity of defective cyanovirin-N mutants is restored by dimerization. J Biol Chem, 285(17), 13057-65, 2010
Black, LR, Aiken, C. TRIM5alpha disrupts the structure of assembled HIV-1 capsid complexes in vitro. J Virol, 84(13), 6564-9, 2010
Shah, VB, Aiken, C. HIV Nuclear Entry: Clearing the Fog. Viruses, 2(5), 1190-4, 2010
Byeon, IJ, Meng, X, Jung, J, Zhao, G, Yang, R, Ahn, J, Shi, J, Concel, J, Aiken, C, Zhang, P, Gronenborn, AM. Structural convergence between Cryo-EM and NMR reveals intersubunit interactions critical for HIV-1 capsid function. Cell, 139(4), 780-90, 2009
Aiken, C. Cell-free assays for HIV-1 uncoating. Methods Mol Biol, 485, 41-53, 2009
Rold, CJ, Aiken, C. Proteasomal degradation of TRIM5alpha during retrovirus restriction. PLoS Pathog, 4(5), e1000074, 2008
Qi, M, Aiken, C. Nef enhances HIV-1 infectivity via association with the virus assembly complex. Virology, 373(2), 287-97, 2008
Langelier, CR, Sandrin, V, Eckert, DM, Christensen, DE, Chandrasekaran, V, Alam, SL, Aiken, C, Olsen, JC, Kar, AK, Sodroski, JG, Sundquist, WI. Biochemical characterization of a recombinant TRIM5alpha protein that restricts human immunodeficiency virus type 1 replication. J Virol, 82(23), 11682-94, 2008
Qi, M, Yang, R, Aiken, C. Cyclophilin A-dependent restriction of human immunodeficiency virus type 1 capsid mutants for infection of nondividing cells. J Virol, 82(24), 12001-8, 2008
Schneidewind, A, Brockman, MA, Yang, R, Adam, RI, Li, B, Le Gall, S, Rinaldo, CR, Craggs, SL, Allgaier, RL, Power, KA, Kuntzen, T, Tung, CS, LaBute, MX, Mueller, SM, Harrer, T, McMichael, AJ, Goulder, PJ, Aiken, C, Brander, C, Kelleher, AD, Allen, TM. Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication. J Virol, 81(22), 12382-93, 2007
Yang, R, Aiken, C. A mutation in alpha helix 3 of CA renders human immunodeficiency virus type 1 cyclosporin A resistant and dependent: rescue by a second-site substitution in a distal region of CA. J Virol, 81(8), 3749-56, 2007
Qi, M, Aiken, C. Selective restriction of Nef-defective human immunodeficiency virus type 1 by a proteasome-dependent mechanism. J Virol, 81(3), 1534-6, 2007
Song, C, Aiken, C. Analysis of Human Cell Heterokaryons Demonstrates that Target Cell Restriction of Cyclosporin A-Resistant HIV-1 Mutants is Genetically Dominant. J Virol, 2007
Pion, M, Arrighi, JF, Jiang, J, Lundquist, CA, Hartley, O, Aiken, C, Piguet, V. Analysis of HIV-1-X4 fusion with immature dendritic cells identifies a specific restriction that is independent of CXCR4 levels. J Invest Dermatol, 127(2), 319-23, 2007
Jiang, J, Aiken, C. Maturation-Dependent HIV-1 Particle Fusion Requires a Carboxyl-Terminal Region of the gp41 Cytoplasmic Tail. J Virol, 81, 9999-10008, 2007
Aiken, C. Viral and cellular factors that regulate HIV-1 uncoating. Curr Opin HIV AIDS, 1(3), 194-9, 2006
Dismuke, DJ, Aiken, C. Evidence for a functional link between uncoating of the human immunodeficiency virus type 1 core and nuclear import of the viral preintegration complex. J Virol, 80(8), 3712-20, 2006
Shi, J, Aiken, C. Saturation of TRIM5 alpha-mediated restriction of HIV-1 infection depends on the stability of the incoming viral capsid. Virology, 350(2), 493-500, 2006
Zhou, J, Chen, CH, Aiken, C. Human immunodeficiency virus type 1 resistance to the small molecule maturation inhibitor 3-O-(3',3'-dimethylsuccinyl)-betulinic acid is conferred by a variety of single amino acid substitutions at the CA-SP1 cleavage site in Gag. J Virol, 80(24), 12095-101, 2006
Davis, MR, Jiang, J, Zhou, J, Freed, EO, Aiken, C. A mutation in the human immunodeficiency virus type 1 Gag protein destabilizes
the interaction of the envelope protein subunits gp120 and gp41. J Virol, 80(5), 2405-17, 2006
Zhou, J, Huang, L, Hachey, DL, Chen, CH, Aiken, C. Inhibition of HIV-1 maturation via drug association with the viral Gag protein
in immature HIV-1 particles. J Biol Chem, 280(51), 42149-55, 2005
Jiang, J, Aiken, C. Maturation of the viral core enhances the fusion of HIV-1 particles with primary
human T cells and monocyte-derived macrophages. Virology, 2005
VanCompernolle, SE, Taylor, RJ, Oswald-Richter, K, Jiang, J, Youree, BE, Bowie, JH, Tyler, MJ, Conlon, JM, Wade, D, Aiken, C, Dermody, TS, KewalRamani, VN, Rollins-Smith, LA, Unutmaz, D. Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency
virus infection and transfer of virus from dendritic cells to T cells. J Virol, 79(18), 11598-606, 2005
Forshey, BM, Shi, J, Aiken, C. Structural requirements for recognition of the human immunodeficiency virus
type 1 core during host restriction in owl monkey cells. J Virol, 79(2), 869-75, 2005
Aiken, C, Chen, CH. Betulinic acid derivatives as HIV-1 antivirals. Trends Mol Med, 11(1), 31-6, 2005
Zhou, Jing, Yuan, Xiong, Dismuke, David, Forshey, Brett M, Lundquist, Christopher, Lee, Kuo-Hsiung, Aiken, Christopher, Chen, Chin Ho. Small-molecule inhibition of human immunodeficiency virus type 1 replication by specific targeting of the final step of virion maturation. J Virol, 78(2), 922-9, 2004
Ganser, B.K., von Schwedler, U.K., Stray, K.M., Aiken, C., and Sundquist, W.I.. Assembly Properties of the HIV-1 CA Protein. J. Virol., 78, 2545-2552, 2004
Lundquist, Christopher A, Zhou, Jing, Aiken, Christopher. Nef stimulates human immunodeficiency virus type 1 replication in primary T cells by enhancing virion-associated gp120 levels: coreceptor-dependent requirement for Nef in viral replication. J Virol, 78(12), 6287-96, 2004
Zhou, Jing, Chen, Chin, Aiken, Christopher. The sequence of the CA-SP1 junction accounts for the differential sensitivity of HIV-1 and SIV to the small molecule maturation inhibitor 3-O-{3'',3''-dimethylsuccinyl}-betulinic acid. Retrovirology, 1(1), 15, 2004
Huang, L. , Yuan, X., Aiken, C., and Chen, C. H.. Bifunctional anti-HIV-1 small molecules with two novel mechanisms of action. Antimicrobial Agents and Chemotherapy , 48, 663-665, 2004
Wyma, Donald J, Jiang, Jiyang, Shi, Jiong, Zhou, Jing, Lineberger, Janet E, Miller, Michael D, Aiken, Christopher. Coupling of human immunodeficiency virus type 1 fusion to virion maturation: a novel role of the gp41 cytoplasmic tail. J Virol, 78(7), 3429-35, 2004
Tobiume, Minoru, Lineberger, Janet E, Lundquist, Christopher A, Miller, Michael D, Aiken, Christopher. Nef does not affect the efficiency of human immunodeficiency virus type 1 fusion with target cells. J Virol, 77(19), 10645-50, 2003
Forshey, Brett M, Aiken, Christopher. Disassembly of human immunodeficiency virus type 1 cores in vitro reveals association of Nef with the subviral ribonucleoprotein complex. J Virol, 77(7), 4409-14, 2003
Forshey, Brett M, von Schwedler, Uta, Sundquist, Wesley I, Aiken, Christopher. Formation of a human immunodeficiency virus type 1 core of optimal stability is crucial for viral replication. J Virol, 76(11), 5667-77, 2002
Lundquist, Christopher A, Tobiume, Minoru, Zhou, Jing, Unutmaz, Derya, Aiken, Christopher. Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes. J Virol, 76(9), 4625-33, 2002
Zhou, J, Aiken, C. Nef enhances human immunodeficiency virus type 1 infectivity resulting from intervirion fusion: evidence supporting a role for Nef at the virion envelope. J Virol, 75(13), 5851-9, 2001
Chazal, N., Singer, G., Aiken, C., Hammarskjold, M.L., and Rekosh, D. HIV-1 particles pseudotyped with envelope proteins that fuse at low pH no longer require Nef for optimal infectivity. J. Virol., 75, 4014-4018, 2001
Wyma, D J, Kotov, A, Aiken, C. Evidence for a stable interaction of gp41 with Pr55(Gag) in immature human immunodeficiency virus type 1 particles. J Virol, 74(20), 9381-7, 2000
Kotov, A, Zhou, J, Flicker, P, Aiken, C. Association of Nef with the human immunodeficiency virus type 1 core. J Virol, 73(10), 8824-30, 1999
Aiken, C. Mechanistic independence of Nef and cyclophilin A enhancement of human immunodeficiency virus type 1 infectivity. Virology, 248(1), 139-47, 1998
Mangasarian, A., Foti, M., Aiken, C., Chin, D., Carpentier, J.-L., and Trono, D. The HIV-1 Nef Protein Acts as a Connector with Sorting Pathways in the Golgi and at the Plasma Membrane. Immunity , 6, 67-77, 1997
Aiken, C. Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein of vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for Nef and the sensitivity to cyclosporin A. J Virol, 71(8), 5871-7, 1997
Foti, M., Carpentier, J.L., Aiken, C., Trono, D., Lew, D. P., Krause, K. H. Second-messenger regulation of receptor association with clathrin-coated pits: a novel and selective mechanism in the control of CD4 endocytosis. Molecular Biology of the Cell, 8, 1377-1389, 1997
Aiken, C., Krause, L., Chen, Y.-L., and Trono, D. Mutational analysis of HIV-1 Nef: identification of two mutants that are temperature- sensitive for CD4 downregulation. Virology , 217, 293-300, 1996
Koval, V., Jault, F. M., Pal, P. G., Moreno, T. N., Aiken, C., Trono, D.,Spector, S. A., and Spector, D. H. Differential Effects of Human Cytomegalovirus on Integrated and Unintegrated Human Immunodeficiency Virus Sequences. J. Virol., 69, 1645-1651, 1995
Gallay, P., Swingler, S., Aiken, C., and Trono, D. HIV-1 Infection of Non-dividing Cells: C-terminal Tyrosine Phosphorylation of the Viral Matrix Protein is a Key Regulator. Cell, 80, 379-388, 1995
Aiken, C., and Trono, D. Nef stimulates human
immunodeficiency virus type 1 proviral DNA synthesis. J. Virol. , 69, 5048-5056, 1995
Aiken, C., Konner, J., Landau, N. R., Lenburg, M. E., and Trono, D. Nef Induces CD4 Endocytosis: Requirement for a Critical Dileucine Motif in the Membrane-Proximal CD4 Cytoplasmic Domain. Cell, 76, 853-864, 1994
Von Schwedler, U., Song, J., Aiken, C., and Trono, D. Vif is crucial for HIV-1 proviral DNA synthesis in infected cells. J. Virol., 67, 4945-4955, 1993
Aiken, C.R., Fisher, E.W., and Gumport, R.I. The Specific Binding, Bending and Unwinding of DNA by RsrI Endonuclease, and Isoschizomer of EcoRI. J. Biol. Chem., 266, 19063-19069, 1991
Aiken, C. and Gumport, R.I. Base Analogues and Their Use in Studying Protein-DNA Interactions. Methods Enzymol, 208, 433-457, 1991
Aiken, C.R., McLaughlin, L.W., and Gumport, R.I. The Highly Homologous Isoschizomers RsrI Endonuclease and EcoRI Endonuclease Do Not Recognize Their Target Sequence Identically. J. Biol. Chem., 266, 19070-19078, 1991
Kaszubska, W., Aiken, C.R., and Gumport, R.I. RsrI restriction-modification enzymes from Rhodobacter spaeroides. Gene , 74, 83-84, 1988
Aiken, C. and Gumport, R.I. Restriction endonuclease RsrI from Rhodobacter sphaeroides, an isoschizomer of EcoRI: purification and properties. Nucleic Acids Res., 16, 7901-7916, 1988
